Pharmacology: Structure and Function of Drug Receptors

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What is the significance of the distance between two consecutive turns of the α-helix in a receptor?

It is a critical factor in drug-receptor interaction

It affects the conformation of the drug

It determines the electronic charge distribution in the receptor

It influences the spacing between peptide bonds (correct)

What is the effect of substituting a bulky group with a small one in a drug molecule?

It changes the molecular formula of the drug

It alters the conformation of the receptor

It increases the electronic charge distribution in the drug

It spatially repositions the groups in the drug molecule (correct)

What is the term used to describe compounds with the same molecular formula but different structures?

Isotopes

Stereoisomers

Isomers (correct)

Analogues

What determines the formation of a complex between a drug and a receptor?

Steric factors Signup and view all the answers

What is the importance of the conformation of the drug and receptor in drug-receptor interaction?

It affects the steric factors of the interaction Signup and view all the answers

What is the term used to describe the distance that separates the two peptide bonds when the protein is extended to the maximum?

Identity distance Signup and view all the answers

What is the primary requirement for the binding forces between a messenger and a receptor?

They must be strong enough to change the shape of the receptor. Signup and view all the answers

Which of the following is a characteristic of a partial agonist?

It binds to the receptor site and blocks access to the natural neurotransmitter. Signup and view all the answers

What is the reason why an antagonist may bind to a different part of the receptor?

Because the receptor protein has areas capable of binding through van der Waals, ionic, or hydrogen bonding forces. Signup and view all the answers

What is the primary purpose of designing a drug molecule with the correct binding groups?

To interact with the receptor and activate its response. Signup and view all the answers

What is the primary concern for a drug molecule's survival in the body?

It must be able to survive destruction in the stomach and liver enzymes. Signup and view all the answers

What is the primary factor determining the success of a drug's journey in the body?

The physical properties of the drug, such as its hydrophilic/hydrophobic balance. Signup and view all the answers

Pharmacology: Structure and Function of Drug Receptors

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