Pharmacology: Structure and Function of Drug Receptors
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Questions and Answers

What is the significance of the distance between two consecutive turns of the α-helix in a receptor?

  • It is a critical factor in drug-receptor interaction
  • It affects the conformation of the drug
  • It determines the electronic charge distribution in the receptor
  • It influences the spacing between peptide bonds (correct)
  • What is the effect of substituting a bulky group with a small one in a drug molecule?

  • It changes the molecular formula of the drug
  • It alters the conformation of the receptor
  • It increases the electronic charge distribution in the drug
  • It spatially repositions the groups in the drug molecule (correct)
  • What is the term used to describe compounds with the same molecular formula but different structures?

  • Isotopes
  • Stereoisomers
  • Isomers (correct)
  • Analogues
  • What determines the formation of a complex between a drug and a receptor?

    <p>Steric factors</p> Signup and view all the answers

    What is the importance of the conformation of the drug and receptor in drug-receptor interaction?

    <p>It affects the steric factors of the interaction</p> Signup and view all the answers

    What is the term used to describe the distance that separates the two peptide bonds when the protein is extended to the maximum?

    <p>Identity distance</p> Signup and view all the answers

    What is the primary requirement for the binding forces between a messenger and a receptor?

    <p>They must be strong enough to change the shape of the receptor.</p> Signup and view all the answers

    Which of the following is a characteristic of a partial agonist?

    <p>It binds to the receptor site and blocks access to the natural neurotransmitter.</p> Signup and view all the answers

    What is the reason why an antagonist may bind to a different part of the receptor?

    <p>Because the receptor protein has areas capable of binding through van der Waals, ionic, or hydrogen bonding forces.</p> Signup and view all the answers

    What is the primary purpose of designing a drug molecule with the correct binding groups?

    <p>To interact with the receptor and activate its response.</p> Signup and view all the answers

    What is the primary concern for a drug molecule's survival in the body?

    <p>It must be able to survive destruction in the stomach and liver enzymes.</p> Signup and view all the answers

    What is the primary factor determining the success of a drug's journey in the body?

    <p>The physical properties of the drug, such as its hydrophilic/hydrophobic balance.</p> Signup and view all the answers

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