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Pharmacology: Sedative-Hypnotic Drugs

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Questions and Answers

What is the primary mechanism of action of zolpidem, zaleplon, and eszopiclone?

Action on a subset of the benzodiazepine receptor family, BZ1 (correct)
Antagonism of 5-HT1A receptors
Inhibition of skeletal muscle relaxants
Activation of GABA receptors

Which of the following is a characteristic of buspirone?

Strong anxiolytic effects with significant sedation
Relief of anxiety with little or no sedative effect (correct)
Potentiation of GABA receptors
Rapid onset of action in acute anxiety states

What is a disadvantage of buspirone?

Significant psychomotor impairment
Rapid onset of action
Potentiation of benzodiazepine receptors
Slow onset of action (correct)

Which of the following is a characteristic of benzodiazepine-receptor agonists?

Weak anxiolytic, anticonvulsant, and skeletal muscle relaxant properties (D) Signup and view all the answers

What is a characteristic of buspirone compared to benzodiazepines?

Less psychomotor impairment (B) Signup and view all the answers

Which of the following is NOT a characteristic of benzodiazepine-receptor agonists?

Strong anxiolytic effects (A) Signup and view all the answers

What is the mechanism of action of buspirone?

Partial agonism at brain 5-HT1A receptors (B) Signup and view all the answers

Which of the following is a characteristic of buspirone discontinuation?

No withdrawal signs are observed (C) Signup and view all the answers

What is the primary difference between benzodiazepine-receptor agonists and benzodiazepines?

Structural unrelatedness (C) Signup and view all the answers

Which of the following is a characteristic of benzodiazepine-receptor agonists in sleep disorders?

Efficacy similar to hypnotic benzodiazepines (D) Signup and view all the answers