Pharmacology: Sedative-Hypnotic Drugs
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Questions and Answers

What is the primary mechanism of action of zolpidem, zaleplon, and eszopiclone?

  • Action on a subset of the benzodiazepine receptor family, BZ1 (correct)
  • Antagonism of 5-HT1A receptors
  • Inhibition of skeletal muscle relaxants
  • Activation of GABA receptors
  • Which of the following is a characteristic of buspirone?

  • Strong anxiolytic effects with significant sedation
  • Relief of anxiety with little or no sedative effect (correct)
  • Potentiation of GABA receptors
  • Rapid onset of action in acute anxiety states
  • What is a disadvantage of buspirone?

  • Significant psychomotor impairment
  • Rapid onset of action
  • Potentiation of benzodiazepine receptors
  • Slow onset of action (correct)
  • Which of the following is a characteristic of benzodiazepine-receptor agonists?

    <p>Weak anxiolytic, anticonvulsant, and skeletal muscle relaxant properties</p> Signup and view all the answers

    What is a characteristic of buspirone compared to benzodiazepines?

    <p>Less psychomotor impairment</p> Signup and view all the answers

    Which of the following is NOT a characteristic of benzodiazepine-receptor agonists?

    <p>Strong anxiolytic effects</p> Signup and view all the answers

    What is the mechanism of action of buspirone?

    <p>Partial agonism at brain 5-HT1A receptors</p> Signup and view all the answers

    Which of the following is a characteristic of buspirone discontinuation?

    <p>No withdrawal signs are observed</p> Signup and view all the answers

    What is the primary difference between benzodiazepine-receptor agonists and benzodiazepines?

    <p>Structural unrelatedness</p> Signup and view all the answers

    Which of the following is a characteristic of benzodiazepine-receptor agonists in sleep disorders?

    <p>Efficacy similar to hypnotic benzodiazepines</p> Signup and view all the answers

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