Pharmacology of Parasympathetic Agonists Quiz
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Pharmacology of Parasympathetic Agonists Quiz

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Questions and Answers

What is the direct effect of Ach on the cardiac muscarinic receptors (M2)?

  • Slowing HR (correct)
  • No effect on HR
  • Irregular heartbeat
  • Increasing HR
  • What is the effect of Ach on the respiratory system?

  • No effect on the respiratory system
  • Bronchodilation
  • Decrease in bronchial secretion
  • Bronchospasm (correct)
  • Which receptor activation leads to vasodilation and lowering of blood pressure?

  • M3 receptors on vascular endothelium (correct)
  • Nicotinic receptors at autonomic ganglia
  • M1 receptors in the CNS
  • M2 receptors in the heart
  • What is the effect of Ach on the eye?

    <p>Miosis</p> Signup and view all the answers

    What is the effect of Ach on the urinary system?

    <p>Contraction of the wall + relaxation of sphincter</p> Signup and view all the answers

    Which cholinesterase inhibitor is used for the diagnosis of myasthenia gravis?

    <p>Edrophonium</p> Signup and view all the answers

    What is the mechanism of action of Rivastigmine in Alzheimer's disease?

    <p>Reversible inhibition of central acetylcholinesterase</p> Signup and view all the answers

    Which condition can be treated with Neostigmine?

    <p>Myasthenia gravis</p> Signup and view all the answers

    What is the primary effect of irreversible anticholinesterases in organophosphorus poisoning?

    <p>Prolonged activation of acetylcholine receptors</p> Signup and view all the answers

    Which neurotransmitter is targeted by Myasthenia gravis antibodies?

    <p>Nicotinic receptors in skeletal muscle</p> Signup and view all the answers

    Study Notes

    Cholinergic Agonists

    • Cholinergic agonists can be classified into two categories: direct cholinergic agonists and indirect cholinergic agonists (anti-cholinesterases)

    Direct Cholinergic Agonists

    • Examples: Cholinomimetic alkaloids (e.g. pilocarpine)
    • Pilocarpine is used topically for pre-operative treatment of closed-angle glaucoma

    Indirect Cholinergic Agonists (Anti-Cholinesterases)

    • Classification based on duration of action:
      • Short-acting: Edrophonium
      • Intermediate-acting: Neostigmine, Pyridostigmine, Rivastigmine
      • Long-acting (Irreversible): Organophosphorus compounds

    Therapeutic Uses of Reversible Cholinesterase Inhibitors

    • Myasthenia gravis
    • Alzheimer's disease
    • Reversal of competitive neuromuscular blockers (NMB) to regain skeletal muscle activity at the end of surgery

    Myasthenia Gravis

    • A disease characterized by fluctuating weakness of voluntary muscles

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    Description

    Test your knowledge of the pharmacology of parasympathetic (cholinergic) agonists, including the clinical pharmacology, autonomic parasympathetic innervation, neuromuscular junction, central neurotransmitter, and pharmacological subtypes of cholinergic receptors.

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