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Pharmacology of Narcotic Analgesics

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Questions and Answers

What is the primary mechanism by which opioids exert their analgesic effects?

By activating opioid receptors and inhibiting neurotransmitter release (correct)

By directly damaging peripheral tissues

By blocking the release of neurotransmitters

By stimulating the release of substance P

What is the main site of extensive metabolism for opioids?

Kidney

Liver (correct)

Lungs

Brain

What is the range of elimination half-life of opioids depending on the specific drug and route of administration?

Hours to days

Hours to weeks

Minutes to hours (correct)

Days to weeks

What is the name of the receptors that opioids bind to in order to exert their analgesic effects?

Opioid receptors Signup and view all the answers

What is the effect of opioid activation on neuronal excitability?

It modulates neuronal excitability Signup and view all the answers

Which of the following opioids is a pure antagonist?

Naloxone Signup and view all the answers

What is a common adverse effect of opioids that can be life-threatening in cases of overdose or misuse?

Respiratory depression Signup and view all the answers

What is a consequence of prolonged use of opioids?

Tolerance and physical dependence Signup and view all the answers

Which of the following is a guideline for the use of opioids?

Prescribe opioids judiciously and use them as part of a comprehensive pain management plan Signup and view all the answers

What is a potential drug interaction with opioids?

Benzodiazepines Signup and view all the answers