Pharmacology of Men's Health Issues
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Questions and Answers

What is the primary neurotransmitter released by the parasympathetic nerves that contributes to erection?

  • Nitric oxide (correct)
  • Acetylcholine
  • Adrenaline
  • Norepinephrine

What is the effect of sympathetic nerves on blood vessels during erection?

  • Increased venous outflow
  • No effect on blood vessels
  • Constriction of blood vessels (correct)
  • Dilation of blood vessels

What is the process by which nitric oxide is released at the synapse?

  • Action potential causes release of calcium into the synapse (correct)
  • Calcium release from the endoplasmic reticulum
  • Nitric oxide is released spontaneously
  • Synaptic vesicle exocytosis

What is the mechanism of action of phosphodiesterase 5 inhibitors in treating erectile dysfunction?

<p>Increase in cyclic guanosine monophosphate degradation (B)</p> Signup and view all the answers

What is the primary cause of erectile dysfunction in men over 40?

<p>Mixed aetiology (C)</p> Signup and view all the answers

What is the effect of detumescence on the corpus cavernosum and corpus spongiosum?

<p>Increased venous outflow (D)</p> Signup and view all the answers

Which of the following medications is a non-selective alpha blocker that causes smooth muscle relaxation?

<p>Phentolamine (D)</p> Signup and view all the answers

What is the primary mechanism of action of papaverine in the treatment of erectile dysfunction?

<p>Inhibition of phosphodiesterase 5 (D)</p> Signup and view all the answers

Which of the following is NOT a potential side effect of alprostadil injections?

<p>Urinary incontinence (B)</p> Signup and view all the answers

What is the primary mechanism of action of PGE1 in the treatment of erectile dysfunction?

<p>Direct vasodilation (B)</p> Signup and view all the answers

Which of the following is a potential complication of intercavernous injections?

<p>Injection site hematoma (A)</p> Signup and view all the answers

What is the primary mechanism of action of prostaglandin E1 in the treatment of erectile dysfunction?

<p>Direct vasodilation (B)</p> Signup and view all the answers

What enzyme is responsible for breaking down cGMP into GMP?

<p>Phosphodiesterase 5 (C)</p> Signup and view all the answers

What is the mechanism by which nitric oxide leaves the synapse?

<p>Simple diffusion (D)</p> Signup and view all the answers

What is the role of parasympathetic arousal pathways in the mechanism of PDE5 inhibitors?

<p>Stimulating the release of nitric oxide (C)</p> Signup and view all the answers

What is the therapeutic priority in the treatment of erectile dysfunction using PDE5 inhibitors?

<p>Inhibit the breakdown of cGMP (A)</p> Signup and view all the answers

What is the site of action of PDE5 inhibitors in the treatment of erectile dysfunction?

<p>Corpus cavernosum and corpus spongiosum (C)</p> Signup and view all the answers

What is the effect of sildenafil citrate on the eyes?

<p>Blue tinge (B)</p> Signup and view all the answers

What is the mechanism by which the parasympathetic nervous system controls urination?

<p>Activation of muscarinic M3 cholinergic receptors, leading to contraction of the detrusor muscle (C)</p> Signup and view all the answers

What is the primary cause of 'urge' incontinence?

<p>Detrusor muscle overactivity due to inflammation or irritation (D)</p> Signup and view all the answers

Which receptor type is responsible for contraction of the urethral sphincter?

<p>Alpha 1 adrenoceptors (A)</p> Signup and view all the answers

What is the mechanism of action of alpha 1 adrenoceptor agonists in treating stress incontinence?

<p>GPCR-mediated contraction, leading to increase in urethral pressure (B)</p> Signup and view all the answers

What is the primary mechanism of action of duloxetine in treating stress incontinence?

<p>Inhibition of noradrenaline reuptake, leading to increased contraction of the urethral sphincter (D)</p> Signup and view all the answers

What is the primary side effect of alpha 1 adrenoceptor agonists?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary effect of noradrenaline on A1 receptors in relation to urinary incontinence?

<p>It has an agonistic effect, leading to a longer duration of action (B)</p> Signup and view all the answers

What is the primary mechanism of action of oestrogen therapy in reducing urinary incontinence in menopausal women?

<p>It has an anabolic effect on the urethral mucosa, reducing the urethral diameter (D)</p> Signup and view all the answers

Which type of receptors do muscarinic antagonists like oxybutynin target in the treatment of urinary incontinence?

<p>M3 receptors (A)</p> Signup and view all the answers

What is the primary indication for using beta 3 agonists like mirabegron in the treatment of urinary incontinence?

<p>When muscarinic antagonists are contraindicated or clinically ineffective (C)</p> Signup and view all the answers

What is the primary advantage of oestrogen therapy in reducing urinary incontinence in menopausal women?

<p>It has a low risk of side effects due to limited bloodstream absorption (C)</p> Signup and view all the answers

What is the primary side effect of muscarinic antagonists like oxybutynin in the treatment of urinary incontinence?

<p>Dry mouth (C)</p> Signup and view all the answers

What is the primary mechanism by which stress incontinence occurs?

<p>The pressure inside the bladder exceeds that applied by the urethra (B)</p> Signup and view all the answers

What is the estimated prevalence of urinary incontinence in the adult female population?

<p>Around 10% (B)</p> Signup and view all the answers

Which of the following is a common scenario in which stress incontinence may occur?

<p>During coughing, sneezing, laughter, etc. (B)</p> Signup and view all the answers

What is the term for the demonstrable involuntary loss of urine?

<p>Urinary incontinence (D)</p> Signup and view all the answers

What is the common cause of displacement of the urethra downwards through the pelvic floor and out of the abdomen?

<p>Childbirth (B)</p> Signup and view all the answers

What is the comparative prevalence of urinary incontinence in males and females?

<p>More common in females (A)</p> Signup and view all the answers

What is the primary mechanism of action of prostate shrinkers in treating enlarged prostate?

<p>They inhibit the activity of 5-alpha-reductase (C)</p> Signup and view all the answers

What is the role of the sympathetic nervous system in the regulation of prostate growth?

<p>It mediates the growth of prostatic cells through the release of noradrenaline (C)</p> Signup and view all the answers

What is the effect of finasteride on prostate size and the need for surgery?

<p>It reduces prostate size by approximately 20% and the need for surgery by approximately 50% (B)</p> Signup and view all the answers

What is the primary side effect of finasteride in treating enlarged prostate?

<p>Loss of libido (A)</p> Signup and view all the answers

What is the mechanism of action of finasteride in treating enlarged prostate?

<p>It is a reversible competitive inhibitor of 5-alpha-reductase (B)</p> Signup and view all the answers

Which type of receptors is targeted by phentolamine to cause smooth muscle relaxation?

<p>Non-selective alpha receptors (A)</p> Signup and view all the answers

What is the primary mechanism of action of papaverine in treating erectile dysfunction?

<p>Inhibition of PDE5, increasing cGMP concentration (C)</p> Signup and view all the answers

What is the role of androgens in prostate growth?

<p>They stimulate the growth of prostatic cells (C)</p> Signup and view all the answers

What is the primary mechanism of action of prostaglandin E1 in the treatment of erectile dysfunction?

<p>Direct vasodilation, increasing blood flow to the penis (B)</p> Signup and view all the answers

What is the primary neurotransmitter released by the parasympathetic nerves that contributes to erection?

<p>Nitric oxide (A)</p> Signup and view all the answers

What is the primary mechanism of action of phosphodiesterase 5 inhibitors in treating erectile dysfunction?

<p>Inhibition of PDE5, increasing cGMP concentration (D)</p> Signup and view all the answers

What is the primary effect of sympathetic nervous system activation on the smooth muscle of the penis?

<p>Contraction, decreasing blood flow to the penis (C)</p> Signup and view all the answers

What is the primary effect of noradrenaline on the blood vessels during erection?

<p>Contraction of smooth muscle (C)</p> Signup and view all the answers

What is the primary mechanism by which phosphodiesterase 5 inhibitors enhance erectile function?

<p>Increased levels of cGMP (C)</p> Signup and view all the answers

What is the primary role of parasympathetic nervous system in the regulation of erection?

<p>Release of nitric oxide (D)</p> Signup and view all the answers

Which of the following is a consequence of inhibition of sympathetic nervous system in the context of erection?

<p>Relaxation of smooth muscle (C)</p> Signup and view all the answers

What is the primary mechanism of nitric oxide release at the synapse?

<p>Action potential causing release of calcium into the synapse (C)</p> Signup and view all the answers

What is the primary consequence of activation of sympathetic nervous system in the context of erection?

<p>Detumescence (D)</p> Signup and view all the answers

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