22 Questions
Which category of pharmacologic modulators includes agents that interrupt the renin-angiotensin axis?
Agents that modify neurohormonal volume regulators
Which type of agents directly target renal ion transporter or channel function to increase renal Na+ excretion?
Classes of diuretics
Which pharmacologic strategy prevents the generation of angiotensin I?
Inhibition of the enzymatic activity of renin
Which agents are competitive antagonists at the AT1 receptor and inhibit the target-organ effects of angiotensin II?
Angiotensin receptor antagonists
Which pharmacologic modulators act directly on Na+ reabsorption through mechanisms less well understood than those of the diuretics?
Agents that modify neurohormonal volume regulators
Which category of pharmacologic modulators includes agents that alter circulating levels of natriuretic peptides?
Agents that modify neurohormonal volume regulators
Which pharmacologic modulators directly target renal ion transporter or channel function to increase renal Na+ excretion?
Agents that modify neurohormonal volume regulators
What is the primary mechanism of action of aliskiren?
Inhibiting the enzymatic activity of renin
In which condition is aliskiren approved for use?
Hypertension with renal insufficiency
What is the recommended combination therapy with aliskiren?
Thiazide diuretics
Why should aliskiren not be combined with ACE inhibitors or ARBs in certain patients?
Increased risk of hyperkalemia
What is the impact of aliskiren on heart failure progression?
It may help in slowing the progression of heart failure
Which step of the RAAS cascade is primarily targeted by aliskiren?
Conversion of angiotensinogen to angiotensin I
In which patients should aliskiren not be combined with ACE inhibitors or ARBs?
Patients with diabetes or chronic kidney disease of stage 3
Which enzyme does aliskiren primarily inhibit?
Renin
In which condition is aliskiren approved for use?
Hypertension with renal insufficiency
What is the recommended combination therapy with aliskiren?
Thiazide diuretics
Why should aliskiren not be combined with ACE inhibitors or ARBs in patients with diabetes or chronic kidney disease of stage 3?
Potential for hyperkalemia
Which pharmacologic modulator directly targets the enzymatic activity of renin to prevent the generation of angiotensin I?
ACE inhibitors
Which pharmacologic modulator acts as a competitive antagonist at the AT1 receptor to inhibit the target-organ effects of angiotensin II?
ACE inhibitors
Which category of pharmacologic modulators directly targets renal ion transporter or channel function to increase renal Na+ excretion?
Diuretics
Which pharmacologic modulator directly blocks aldosterone action at the nephron collecting duct?
Aldosterone receptor antagonists
Test your knowledge of pharmacologic classes and agents that modulate extracellular fluid volume. Explore agents that modify neurohormonal volume regulators and those that act directly on nephron segments to alter renal Na+ handling. Learn about interrupting the renin-angiotensin axis, altering natriuretic peptide levels, and interrupting ADH signaling.
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