Podcast
Questions and Answers
Which category of pharmacologic modulators includes agents that interrupt the renin-angiotensin axis?
Which category of pharmacologic modulators includes agents that interrupt the renin-angiotensin axis?
Which type of agents directly target renal ion transporter or channel function to increase renal Na+ excretion?
Which type of agents directly target renal ion transporter or channel function to increase renal Na+ excretion?
Which pharmacologic strategy prevents the generation of angiotensin I?
Which pharmacologic strategy prevents the generation of angiotensin I?
Which agents are competitive antagonists at the AT1 receptor and inhibit the target-organ effects of angiotensin II?
Which agents are competitive antagonists at the AT1 receptor and inhibit the target-organ effects of angiotensin II?
Signup and view all the answers
Which pharmacologic modulators act directly on Na+ reabsorption through mechanisms less well understood than those of the diuretics?
Which pharmacologic modulators act directly on Na+ reabsorption through mechanisms less well understood than those of the diuretics?
Signup and view all the answers
Which category of pharmacologic modulators includes agents that alter circulating levels of natriuretic peptides?
Which category of pharmacologic modulators includes agents that alter circulating levels of natriuretic peptides?
Signup and view all the answers
Which pharmacologic modulators directly target renal ion transporter or channel function to increase renal Na+ excretion?
Which pharmacologic modulators directly target renal ion transporter or channel function to increase renal Na+ excretion?
Signup and view all the answers
What is the primary mechanism of action of aliskiren?
What is the primary mechanism of action of aliskiren?
Signup and view all the answers
In which condition is aliskiren approved for use?
In which condition is aliskiren approved for use?
Signup and view all the answers
What is the recommended combination therapy with aliskiren?
What is the recommended combination therapy with aliskiren?
Signup and view all the answers
Why should aliskiren not be combined with ACE inhibitors or ARBs in certain patients?
Why should aliskiren not be combined with ACE inhibitors or ARBs in certain patients?
Signup and view all the answers
What is the impact of aliskiren on heart failure progression?
What is the impact of aliskiren on heart failure progression?
Signup and view all the answers
Which step of the RAAS cascade is primarily targeted by aliskiren?
Which step of the RAAS cascade is primarily targeted by aliskiren?
Signup and view all the answers
In which patients should aliskiren not be combined with ACE inhibitors or ARBs?
In which patients should aliskiren not be combined with ACE inhibitors or ARBs?
Signup and view all the answers
Which enzyme does aliskiren primarily inhibit?
Which enzyme does aliskiren primarily inhibit?
Signup and view all the answers
In which condition is aliskiren approved for use?
In which condition is aliskiren approved for use?
Signup and view all the answers
What is the recommended combination therapy with aliskiren?
What is the recommended combination therapy with aliskiren?
Signup and view all the answers
Why should aliskiren not be combined with ACE inhibitors or ARBs in patients with diabetes or chronic kidney disease of stage 3?
Why should aliskiren not be combined with ACE inhibitors or ARBs in patients with diabetes or chronic kidney disease of stage 3?
Signup and view all the answers
Which pharmacologic modulator directly targets the enzymatic activity of renin to prevent the generation of angiotensin I?
Which pharmacologic modulator directly targets the enzymatic activity of renin to prevent the generation of angiotensin I?
Signup and view all the answers
Which pharmacologic modulator acts as a competitive antagonist at the AT1 receptor to inhibit the target-organ effects of angiotensin II?
Which pharmacologic modulator acts as a competitive antagonist at the AT1 receptor to inhibit the target-organ effects of angiotensin II?
Signup and view all the answers
Which category of pharmacologic modulators directly targets renal ion transporter or channel function to increase renal Na+ excretion?
Which category of pharmacologic modulators directly targets renal ion transporter or channel function to increase renal Na+ excretion?
Signup and view all the answers
Which pharmacologic modulator directly blocks aldosterone action at the nephron collecting duct?
Which pharmacologic modulator directly blocks aldosterone action at the nephron collecting duct?
Signup and view all the answers
