Pharmacology of Beta Blockers

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Questions and Answers

What is the result of blocking the sympathetic nervous system stimulation on hepatic glucose production?

  • Variable effect on glucose production
  • No effect on glucose production
  • Increased glucose production
  • Decreased glucose production (correct)

Which of the following beta blockers is more likely to cause hypoglycemia?

  • Metoprolol
  • Esmolol
  • Atenolol
  • Propranolol (correct)

What is the effect of beta blockers on bronchospasm in patients with asthma or COPD?

  • Variable effect on bronchospasm
  • Relief of bronchospasm
  • No effect on bronchospasm
  • Exacerbation of bronchospasm (correct)

Which of the following beta blockers is the most selective for the beta-1 receptor?

<p>Atenolol (B)</p> Signup and view all the answers

What is the effect of propranolol on infantile hemangioma cell growth?

<p>Represses cell growth (A)</p> Signup and view all the answers

What is the consequence of sudden withdrawal of beta blockers?

<p>Increased catecholamine sensitivity (C)</p> Signup and view all the answers

What is the effect of an alpha 1 agonist on vasoconstriction?

<p>Increase vasoconstriction (B)</p> Signup and view all the answers

What is the mechanism of action of prazosin in relation to alpha 1 receptors?

<p>Acts as an inverse agonist at the A1 adrenergic receptor (B)</p> Signup and view all the answers

Why is phentolamine contraindicated in patients with hypotension and bradycardia?

<p>It can cause reflex bradycardia (C)</p> Signup and view all the answers

What is the primary effect of alpha 2 antagonists on norepinephrine release?

<p>Increase norepinephrine release (A)</p> Signup and view all the answers

What is the primary indication for phentolamine?

<p>Pheochromocytoma (B)</p> Signup and view all the answers

What is the effect of alpha 1 blockade on peripheral resistance?

<p>Decrease peripheral resistance (D)</p> Signup and view all the answers

Which of the following alpha1-adrenergic blockers is specifically used to treat BPH?

<p>Tamsulosin (C)</p> Signup and view all the answers

What is the main concern when administering alpha1 blockers to patients with renal failure?

<p>Increased drug sensitivity (D)</p> Signup and view all the answers

Which of the following beta blockers has both non-selective beta receptor antagonist and alpha receptor antagonist properties?

<p>Labetalol (B)</p> Signup and view all the answers

What is the primary indication for the use of Prazosin?

<p>Hypertension and BPH (A)</p> Signup and view all the answers

What is the volume of distribution of Prazosin?

<p>0.6 L/kg (D)</p> Signup and view all the answers

Which of the following is a common side effect of Prazosin?

<p>All of the above (D)</p> Signup and view all the answers

What is the half-life of Propranolol?

<p>3.9-6.4 hours (C)</p> Signup and view all the answers

When is IV use of Propranolol indicated?

<p>For the management of life-threatening arrhythmias (D)</p> Signup and view all the answers

What is the sequence of treatment for pheochromocytoma?

<p>PO alpha blockade followed by PO beta blockade (D)</p> Signup and view all the answers

Which of the following beta blockers is very lipid soluble and can cross the BBB?

<p>Propranolol (C)</p> Signup and view all the answers

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