Pharmacology of Agonist and Antagonist Relationships

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What is the effect of a small dose of Ach administered before atropine?

Increased heart rate
Stimulation of nicotinic receptors
No effect on heart rate
Decreased heart rate (correct)

What is the effect of a small dose of adrenaline administered in a new non-pretreated preparation?

Decrease in heart rate
Increase in blood pressure (correct)
No effect on blood pressure
Vasoconstriction

What is the effect of atropine on the action of Ach?

Blocks the effect of Ach (correct)
Reverses the effect of Ach
Enhances the effect of Ach
Has no effect on the action of Ach

What is the effect of prazosin on the action of adrenaline?

Blocks the effect of adrenaline on alpha-1 receptors (C) Signup and view all the answers

What is the effect of a large dose of Ach administered after atropine?

Increased heart rate (A) Signup and view all the answers

What is the effect of propranolol on the action of adrenaline?

Blocks the effect of adrenaline on beta receptors (D) Signup and view all the answers

What is a characteristic of an agonist drug?

It has structural features that allow it to fit properly on its receptors (D) Signup and view all the answers

What is the primary mechanism of action of a competitive antagonist?

It competes with the agonist for receptor binding sites (C) Signup and view all the answers

What is the effect of an antagonist on the action of an agonist?

It prevents the agonist from combining with its receptors (B) Signup and view all the answers

What is the effect of a non-competitive antagonist on the dose-response curve of the agonist?

It shifts the curve downwards (C) Signup and view all the answers

What is the intrinsic activity of a partial agonist compared to a full agonist?

It is less than 1 (B) Signup and view all the answers

What is the result of administering a competitive antagonist to a system with an agonist present?

The agonist is displaced from the receptor binding sites (A) Signup and view all the answers

What is the primary difference between an agonist and an antagonist?

Their ability to elicit a response (D) Signup and view all the answers

What is the effect of a partial agonist on the response of a full agonist?

It decreases the response of the full agonist (B) Signup and view all the answers

In the sequence of drug administration, what is the purpose of the second dose of Ach?

To test the reversibility of the antagonist (C) Signup and view all the answers

What is the characteristic of a non-competitive antagonist's binding to the receptor?

It is irreversible (A) Signup and view all the answers

What can be said about the intrinsic activity of a pure antagonist?

It is equal to 0 (B) Signup and view all the answers

What is the expected observation after administering Atropine in the sequence of drug administration?

A decrease in the frequency of receptor activation (C) Signup and view all the answers