18 Questions
What is the effect of a small dose of Ach administered before atropine?
Decreased heart rate
What is the effect of a small dose of adrenaline administered in a new non-pretreated preparation?
Increase in blood pressure
What is the effect of atropine on the action of Ach?
Blocks the effect of Ach
What is the effect of prazosin on the action of adrenaline?
Blocks the effect of adrenaline on alpha-1 receptors
What is the effect of a large dose of Ach administered after atropine?
Increased heart rate
What is the effect of propranolol on the action of adrenaline?
Blocks the effect of adrenaline on beta receptors
What is a characteristic of an agonist drug?
It has structural features that allow it to fit properly on its receptors
What is the primary mechanism of action of a competitive antagonist?
It competes with the agonist for receptor binding sites
What is the effect of an antagonist on the action of an agonist?
It prevents the agonist from combining with its receptors
What is the effect of a non-competitive antagonist on the dose-response curve of the agonist?
It shifts the curve downwards
What is the intrinsic activity of a partial agonist compared to a full agonist?
It is less than 1
What is the result of administering a competitive antagonist to a system with an agonist present?
The agonist is displaced from the receptor binding sites
What is the primary difference between an agonist and an antagonist?
Their ability to elicit a response
What is the effect of a partial agonist on the response of a full agonist?
It decreases the response of the full agonist
In the sequence of drug administration, what is the purpose of the second dose of Ach?
To test the reversibility of the antagonist
What is the characteristic of a non-competitive antagonist's binding to the receptor?
It is irreversible
What can be said about the intrinsic activity of a pure antagonist?
It is equal to 0
What is the expected observation after administering Atropine in the sequence of drug administration?
A decrease in the frequency of receptor activation
This quiz assesses your understanding of the effects of Acetylcholine and Adrenaline on blood pressure and heart rate, and their interactions with blockers. It also covers the definitions and types of agonists, antagonists, and partial agonists. Test your knowledge of pharmacological relationships!
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