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Paramedic Drug Administration naloxone

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Questions and Answers

What is the trade name of naloxone?

Narcan (correct)

Advil

Tylenol

Aspirin

What is the mechanism of action for naloxone?

It stimulates opioid receptors to reduce pain.

Naloxone competitively binds to opioid receptors in the central nervous system, displaces opioid molecules, reversing the effect of narcotics and synthetic analgesic drugs on the brain (central nervous system depression, respiratory depression, respiratory arrest). (correct)

It inhibits the reuptake of serotonin and norepinephrine.

It acts as an opioid antagonist at mu, kappa, and delta receptors.

What is the class of naloxone?

Narcotic antagonist (correct)

Opioid agonist

Benzodiazepine

Non-steroidal anti-inflammatory drug

What are the indications for naloxone?

Reversal of acute opioid and opiate toxicity Signup and view all the answers

What are the contraindications for naloxone?

Naloxone allergy Signup and view all the answers

What are the adverse reactions/side effects of naloxone?

Confusion, hypotension, agitation, tachycardia, hypertension, pulmonary edema, dysrhythmias, diaphoresis, nausea, vomiting, and seizures (in neonates.) Signup and view all the answers

What are the routes of administration for naloxone?

IV/IM/IN/IO Signup and view all the answers

What is the onset of action for naloxone?

< 2 minutes Signup and view all the answers

What is the duration of action for naloxone?

20 to 120 minutes Signup and view all the answers

What is the adult dose for naloxone?

0.4-2 mg IV/IO/IM/IN. Repeat if indicated. Signup and view all the answers

What is the pediatric dose for naloxone for respiratory depression? (Perform immediate resuscitation first, then consider)

BLS IN: 4 mg/0.1 mL nasal spray, 1 spray in single nostril, may be repeated as indicated; ALS Naloxone: 0.1 mg/kg IV/IO/IM/IN. Repeat if indicated. Signup and view all the answers

What are the special considerations for the administration of naloxone in the prehospital setting?

Identify medication taken, noting immediate release vs. sustained release formulations, time of ingestion, and quantity. Bring pill container(s) to hospital, if possible (or take pictures with photography equipped, agency-owned device). Assess for other etiologies of altered mental status including hypoxia, hypoglycemia, hypotension, and traumatic head injury. Monitor for recurrent respiratory depression and decreased mental status. Recommend transport to hospital. If patient refuses transfer, with or without receiving naloxone, call the Arizona Opioid Assistance and Referral (OAR) Line at 888-688-4222. Signup and view all the answers