Pharmacology: Injection Methods and Dosage Forms
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Questions and Answers

What is the advantage of the IV route?

  • It provides rapid action as the drug is directly introduced into the systemic circulation (correct)
  • It reduces the risk of thrombosis
  • It is the method of choice for depot action
  • It allows for controlled release of the drug
  • What is the risk associated with the IV route?

  • Muscle or nerve damage
  • Thrombosis (correct)
  • Irritation due to high concentration of the drug
  • Extravasation
  • What is the purpose of aspiration prior to injecting a drug in the IM and SC routes?

  • To control the release rate of the drug
  • To increase the injection volume
  • To avoid blood in the injection site (correct)
  • To ensure the needle is in the vein
  • What is the term used to describe the process of increasing injection volumes in the SC route?

    <p>Hypodermoclysis</p> Signup and view all the answers

    What is the enzyme used to enhance tissue permeability in the SC route?

    <p>Hyaluronidase</p> Signup and view all the answers

    What is the method of choice for depot action?

    <p>IM route</p> Signup and view all the answers

    What is the main reason for administering injections slowly?

    <p>To avoid pain or tissue damage</p> Signup and view all the answers

    Which of the following medications is administered by the SC route?

    <p>Insulin and low molecular-weight heparins</p> Signup and view all the answers

    What is the main advantage of using needleless injectors?

    <p>Reduced risk of skin puncture hazards</p> Signup and view all the answers

    What is a limitation of needleless injectors?

    <p>They are not applicable for IV route</p> Signup and view all the answers

    What is the main advantage of using needleless injectors in terms of drug delivery?

    <p>Improved bioavailability</p> Signup and view all the answers

    What is the purpose of large volume parenterals (LVPs)?

    <p>To administer infusion fluids in larger volumes</p> Signup and view all the answers

    What is the primary reason for having the drug in sufficient concentration in parenteral dosage forms?

    <p>To achieve the desired dose in the small injected volume</p> Signup and view all the answers

    How can the solubility of a drug be enhanced?

    <p>By chemical modification of the drug as salt or ester formation</p> Signup and view all the answers

    What can affect the dissolution of a drug?

    <p>The crystal characteristics of the drug</p> Signup and view all the answers

    Why is it important to control crystallization in parenteral products?

    <p>To control lot to lot variation</p> Signup and view all the answers

    What is a potential issue with hydrates or anhydrous drugs?

    <p>Require special control of RH and solvent purity</p> Signup and view all the answers

    Why is it important to minimize the use of excipients in parenteral products?

    <p>To avoid any undesirable irritation, incompatibility, or stability problems</p> Signup and view all the answers

    What is the reason for carefully weighing the use of preservatives in formulations?

    <p>To minimize the risk of formulation issues that reduce preservative concentration</p> Signup and view all the answers

    Which of the following preservatives is less active at pH above 5 and unstable at pH 6?

    <p>Chlorbutol</p> Signup and view all the answers

    Why should preservatives not be used in LVPs (large volume parenterals)?

    <p>Because of the risk of administering toxic quantities</p> Signup and view all the answers

    What is a common issue with preservatives in oily formulations?

    <p>They tend to partition in favor of the oily droplets, reducing efficacy</p> Signup and view all the answers

    Why is there a trend to avoid the use of preservatives in some formulations?

    <p>Because of the possibility of using aseptic conditions instead</p> Signup and view all the answers

    What is a consideration when selecting a preservative for a formulation?

    <p>The pH of the formulation</p> Signup and view all the answers

    What is the most commonly used solvent for parenteral formulations?

    <p>Water for injection (WFI)</p> Signup and view all the answers

    What is the purpose of boiling WFI for 10 minutes?

    <p>To remove carbon dioxide</p> Signup and view all the answers

    Why is O2-free WFI used for certain injections?

    <p>To prevent oxidation</p> Signup and view all the answers

    What is the risk associated with using sesame oil in parenteral formulations?

    <p>Rancidity</p> Signup and view all the answers

    What is the advantage of using esters as an alternative to fixed oils?

    <p>They are less viscous</p> Signup and view all the answers

    Why are alcohols used as cosolvents in parenteral formulations?

    <p>To improve solubility</p> Signup and view all the answers

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