Pharmacology Extended vs Immediate Release Quiz
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Questions and Answers

What distinguishes an extended release drug product from an immediate release drug product?

  • It releases the active pharmaceutical ingredient immediately.
  • It always requires a higher dosage than immediate release.
  • It is only available in capsule form.
  • It has a modified release rate compared to immediate release. (correct)

    • Why might an extended release formulation demonstrate a different efficacy profile than an immediate release formulation of the same drug?

  • It contains a higher concentration of the active ingredient.
  • It is usually administered intravenously.
  • It is absorbed faster than immediate release formulations.
  • It delivers the drug over a prolonged period, affecting the pharmacodynamics. (correct)

    • In what circumstance should an extended release drug product include an immediate release dose?

  • When prolonged release is unnecessary.
  • When side effects are minimized.
  • When the drug has a high absorption rate.
  • When rapid onset of effect is required. (correct)

    • What is a potential advantage of using extended release beads in a capsule formulation?

    <p>They allow for a longer duration of action.</p> Signup and view all the answers

    Which of the following is NOT a typical characteristic of conventional (immediate release) drug products?

    <p>They are designed to have a prolonged release of medication.</p> Signup and view all the answers

    Which of the following best describes a transdermal drug product?

    <p>It is considered an extended release formulation.</p> Signup and view all the answers

    What is a common disadvantage of extended release drug products compared to immediate release products?

    <p>They can have a delayed onset of action.</p> Signup and view all the answers

    Which of the following studies is least likely required for the development of an extended release drug product?

    <p>Activation studies.</p> Signup and view all the answers

    What is a factor that can hinder a drug's ability to cross biological barriers?

    <p>High molecular weight</p> Signup and view all the answers

    What can cause rapid drug inactivation in the body?

    <p>Fast drug metabolism</p> Signup and view all the answers

    What is the goal of an ideal drug delivery system?

    <p>To release the drug at a rate that matches the therapeutic need</p> Signup and view all the answers

    What does the term ‘minimal effective concentration’ (MEC) refer to?

    <p>The lowest concentration required for therapeutic effect</p> Signup and view all the answers

    Which of the following can lead to therapy failure in vivo?

    <p>Limiting dosage due to side effects</p> Signup and view all the answers

    What is the primary advantage of modified release (MR) drug products over conventional immediate release (IR) formulations?

    <p>They provide a consistent drug absorption rate over time.</p> Signup and view all the answers

    How do MR drug products aim to improve patient compliance?

    <p>By enabling sustained therapeutic effects with fewer doses.</p> Signup and view all the answers

    What is the purpose of time-controlled drug delivery systems?

    <p>To optimize concentration–time profiles</p> Signup and view all the answers

    What is the main objective of using MR drug products for oral administration?

    <p>To prolong the therapeutic effect of the drug.</p> Signup and view all the answers

    What does the term 'modified release' specifically refer to?

    <p>Drugs with a defined time course and location of drug release.</p> Signup and view all the answers

    What is one of the key aspects encompassed by 'controlled drug delivery'?

    <p>Rate and timing of drug release</p> Signup and view all the answers

    What is a primary disadvantage of traditional immediate release (IR) formulations as compared to MR formulations?

    <p>They result in less consistent drug levels in the bloodstream.</p> Signup and view all the answers

    What is P-glycoprotein's role in the body regarding drug action?

    <p>Facilitating drug efflux</p> Signup and view all the answers

    Which of the following statements accurately describes the potential benefits of MR drug products?

    <p>They can enhance clinical and therapeutic benefits.</p> Signup and view all the answers

    How do MR formulations affect the occurrence of adverse effects compared to conventional formulations?

    <p>They reduce peak-trough fluctuations that may be associated with adverse effects.</p> Signup and view all the answers

    What therapeutic benefit is associated with the controlled release characteristics of MR medications?

    <p>Improving the convenience of taking medications.</p> Signup and view all the answers

    What is the term used to describe the range between two drug concentrations?

    <p>Therapeutic window</p> Signup and view all the answers

    What happens when a highly potent drug in a conventional dosage form is administered?

    <p>The entire drug dose is rapidly released.</p> Signup and view all the answers

    Which characteristic of a drug poses a risk of achieving toxic concentrations during treatment?

    <p>High potency with a narrow therapeutic range</p> Signup and view all the answers

    What is a major limitation of immediate-release dosage forms for certain drugs?

    <p>They do not provide a sustained drug supply.</p> Signup and view all the answers

    What advantage do time-controlled drug delivery systems provide?

    <p>They enable constant drug concentrations within the therapeutic range.</p> Signup and view all the answers

    What consequence can arise from the quick elimination of a drug from the body after immediate release?

    <p>Subtherapeutic drug concentrations</p> Signup and view all the answers

    Why might certain drugs require daytime-dependent concentrations?

    <p>To match with circadian fluctuations in hormone concentrations.</p> Signup and view all the answers

    What must be considered when using drugs that exhibit a narrow therapeutic range?

    <p>They require frequent monitoring to prevent toxicity.</p> Signup and view all the answers

    What is a significant advantage of time-controlled drug delivery systems for patients?

    <p>They improve patient compliance through simplified administration schedules.</p> Signup and view all the answers

    How does the drug concentration curve appear when using a controlled-release system compared to an immediate-release system?

    <p>Thicker and more constant</p> Signup and view all the answers

    What is the primary issue that still limits the success of various pharmaco-therapies?

    <p>Inappropriate or inaccurate administration of drugs.</p> Signup and view all the answers

    How does a pulsatile drug-release profile function in controlled drug delivery systems?

    <p>It remains inactive during part of the night and releases the drug after a predetermined time.</p> Signup and view all the answers

    Which of the following is one way to classify time-controlled drug delivery systems?

    <p>Based on the route of administration and drug-release mechanisms.</p> Signup and view all the answers

    What is one characteristic of reservoir systems among diffusion-controlled drug delivery systems?

    <p>They have a fixed rate of drug release independent of external conditions.</p> Signup and view all the answers

    What type of drug administration might be simplified to once a month through controlled delivery systems?

    <p>Parenteral administration.</p> Signup and view all the answers

    What challenge do elderly patients face that may impact the effectiveness of drug therapies?

    <p>They often have multiple, complicated drug treatments.</p> Signup and view all the answers

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