Pharmacology Chapter: Drug Excretion and Metabolism
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Questions and Answers

What is the impact of a drug with a short half-life on dosing frequency?

  • Requires infrequent dosing
  • Requires a high dose each time
  • Requires frequent dosing (correct)
  • Requires no dosing
  • Which half-life duration indicates that a drug can be administered less frequently?

  • 21–24 hours (correct)
  • 10–15 hours
  • 1–2 hours
  • 2–4 hours
  • If a drug has a half-life of 3 hours, what can be concluded about its dosing schedule?

  • It should be taken once a day
  • It should be taken every several hours (correct)
  • It can be taken once every two days
  • It requires continuous infusion
  • What is the significance of knowing a drug's half-life?

    <p>It guides dosing frequency planning</p> Signup and view all the answers

    A patient is prescribed a medication with a half-life of 22 hours. What dosing recommendation would be appropriate?

    <p>Take once every 24 hours</p> Signup and view all the answers

    What is the primary route of excretion for most drugs and drug metabolites?

    <p>Renal excretion</p> Signup and view all the answers

    Which of the following statements about renal excretion is true?

    <p>It quantitatively dominates drug excretion.</p> Signup and view all the answers

    Which drugs are excreted unchanged by the kidney?

    <p>Some drugs are excreted unchanged.</p> Signup and view all the answers

    What role does the liver play in drug excretion?

    <p>It is not involved in the renal excretion of some drugs.</p> Signup and view all the answers

    Which of the following best describes renal excretion?

    <p>A quantitatively important route for drug excretion.</p> Signup and view all the answers

    Study Notes

    Renal Excretion

    • The kidneys are the primary route of excretion for most drugs and their metabolites.
    • Drugs with short half-lives (2-4 hours) require frequent administration.
    • Drugs with long half-lives (21-24 hours) require less frequent administration.
    • The half-life of a drug determines the frequency of dosing.

    Drug Metabolism

    • The liver is the primary site of drug metabolism.
    • Some drugs are excreted unchanged by the kidneys without liver involvement.
    • Liver disease can affect drug metabolism.
    • The kidneys, lungs, plasma, and intestinal mucosa also contribute to drug metabolism.
    • Enzyme inhibition or induction can affect drug metabolism.
    • Only unbound drugs in the blood can diffuse across cell membranes into tissues.

    Drug Receptors

    • There are different types of drug receptors:
      • Alpha and beta adreno-receptors.
      • Intracellular receptors (found in the cytoplasm or cell): binding of the drug to the receptor results in protein production (e.g., steroid receptors).

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    Description

    This quiz covers key concepts in pharmacology related to renal excretion, drug metabolism, and the types of drug receptors. Understand how drugs are processed in the body, the influence of half-lives on dosing frequency, and the role of various organs in drug metabolism. Test your knowledge on these critical topics to enhance your understanding of pharmacology.

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