Pharmacology Basics Quiz

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Questions and Answers

Which term best describes the study of how drugs affect living organisms?

  • Toxicology
  • Pharmacology (correct)
  • Pharmacokinetics
  • Pharmaceutics

What is the term used to describe how the body processes drugs, including absorption, distribution, and excretion?

  • Pharmacotherapeutics
  • Pharmacogenomics
  • Pharmacodynamics
  • Pharmacokinetics (correct)

Which of the following describes a drug's registered trademark name?

  • Nonproprietary name
  • Generic name
  • Proprietary name (correct)
  • Chemical name

A drug's chemical structure and composition are described by its:

<p>Chemical name (B)</p> Signup and view all the answers

What is the typical length of patent protection for a newly discovered drug molecule?

<p>17 years (B)</p> Signup and view all the answers

Why are trade names typically easier to remember than generic drug names?

<p>They are designed for marketability. (B)</p> Signup and view all the answers

Which of the following best defines a 'biosimilar' drug?

<p>A copy version of an authorized biological product (B)</p> Signup and view all the answers

What is a main characteristic of generic drugs after a patent for a drug expires?

<p>They have the same active ingredient as the original drug. (B)</p> Signup and view all the answers

What primarily causes idiosyncratic drug reactions?

<p>Genetically determined abnormal responses (B)</p> Signup and view all the answers

What study focuses on understanding genetic traits revealed through drug administration?

<p>Pharmacogenomics (C)</p> Signup and view all the answers

Which deficiency is given as an example of an idiosyncratic drug reaction?

<p>Glucose-6-phosphate dehydrogenase (G6PD) deficiency (D)</p> Signup and view all the answers

What is a common consequence of drug interactions?

<p>Unexpected unwanted effects (B)</p> Signup and view all the answers

What triggers idiosyncratic reactions to drugs?

<p>Abnormal drug-metabolizing enzyme levels (A)</p> Signup and view all the answers

What must be proven before one drug can be therapeutically substituted for another?

<p>The drugs must have the same therapeutic effect on the body. (C)</p> Signup and view all the answers

Which of the following best describes pharmacodynamics?

<p>What the drug does to the body. (B)</p> Signup and view all the answers

Why are prototypical drugs significant in pharmacology?

<p>They are the first drugs in a class and are key examples. (A)</p> Signup and view all the answers

What is the primary focus of pharmacotherapeutics?

<p>Clinical use of drugs for preventing and treating diseases. (C)</p> Signup and view all the answers

How are drugs categorized by their pharmacologic classes?

<p>By their physiological functions and the main diseases they treat. (B)</p> Signup and view all the answers

What is the study of toxicology primarily concerned with?

<p>The effects of drugs on living systems. (C)</p> Signup and view all the answers

Which of the following describes the role of pharmacokinetics?

<p>It studies the body's effects on the drug, including absorption and excretion. (A)</p> Signup and view all the answers

What factor determines the rate at which drug dissolution occurs?

<p>Dosage form. (C)</p> Signup and view all the answers

Which type of drug is designed to resist disintegration in the stomach's acidic environment?

<p>Enteric-coated tablets. (A)</p> Signup and view all the answers

What happens to previously off-label drug indications over time?

<p>They may eventually be approved by the FDA. (A)</p> Signup and view all the answers

What is pharmacoeconomics primarily concerned with?

<p>The financial aspects of drug therapy. (C)</p> Signup and view all the answers

Which of the following is NOT a focus of the study of pharmaceutics?

<p>Selection of appropriate medications. (A)</p> Signup and view all the answers

How does particle size affect the absorption of a drug?

<p>It affects the rate of dissolution and absorption. (B)</p> Signup and view all the answers

What is a primary advantage of sublingual drug administration?

<p>Avoids first-pass metabolism (D)</p> Signup and view all the answers

What is a potential disadvantage of the rectal route for drug administration?

<p>Possible discomfort and embarrassment (C)</p> Signup and view all the answers

Why might topical medications sometimes be messy or awkward to self-administer?

<p>They are often in a liquid form. (D)</p> Signup and view all the answers

What is a key nursing consideration when administering transdermal medications?

<p>Ensure the previous patch is removed before applying a new one. (B)</p> Signup and view all the answers

In terms of drug distribution, which areas of the body receive drugs first due to extensive blood supply?

<p>Heart, liver, kidneys, and brain (A)</p> Signup and view all the answers

What can cause an increased risk of drug toxicity in patients with low albumin levels?

<p>Higher concentrations of free (unbound) drug (A)</p> Signup and view all the answers

What is a significant concern regarding inhalational drug administration?

<p>Potential for rapid onset of exaggerated drug effects (B)</p> Signup and view all the answers

Which route of administration can lead to both first-pass and non-first-pass metabolism effects?

<p>Rectal (D)</p> Signup and view all the answers

What must be done to the skin before applying a transdermal patch?

<p>Cleanse and dry the area where the patch will be placed. (B)</p> Signup and view all the answers

Which characteristic defines the buccal route of drug administration?

<p>Inserted between the cheek and gum (A)</p> Signup and view all the answers

What is one disadvantage of using the topical route for medication delivery?

<p>Variable absorption rates among patients (A)</p> Signup and view all the answers

What is an important factor regarding absorption when using inhalational routes?

<p>The rate of absorption can be too rapid. (C)</p> Signup and view all the answers

The presence of which protein affects the pharmacological activity of a drug in the bloodstream?

<p>Albumin (B)</p> Signup and view all the answers

What is a significant advantage of extended-release dosage forms over immediate-release forms?

<p>They allow for prolonged drug absorption. (C)</p> Signup and view all the answers

Why should extended-release tablets not be crushed?

<p>Crushing can lead to accelerated release of the drug. (A)</p> Signup and view all the answers

Which of the following terms indicates a form of extended-release dosage?

<p>SR (B)</p> Signup and view all the answers

What must be considered when crushing a medication for administration?

<p>Consultation with a pharmacist is advised if unsure. (A)</p> Signup and view all the answers

What role does the liver play in drug absorption for orally administered medications?

<p>It can chemically change drugs into inactive metabolites. (C)</p> Signup and view all the answers

How are topical dosage forms generally characterized?

<p>They act directly on the skin surface or must penetrate through the skin. (C)</p> Signup and view all the answers

What is meant by bioavailability?

<p>The fraction of an administered drug that reaches systemic circulation. (C)</p> Signup and view all the answers

Which type of dosage form is specifically designed to dissolve in the mouth?

<p>Orally disintegrating tablets (C)</p> Signup and view all the answers

What is the primary advantage of parenteral medication administration?

<p>Bypassing the first-pass effect of the liver (A)</p> Signup and view all the answers

Which route of parenteral administration delivers drugs directly into the bloodstream?

<p>Intravenous injection (A)</p> Signup and view all the answers

What must be similar for parenteral forms to be safe for injection?

<p>They should have a pH similar to that of blood. (C)</p> Signup and view all the answers

What is the typical onset time for a medication administered intravenously compared to orally?

<p>IV - 5 minutes; PO - 30 to 60 minutes (B)</p> Signup and view all the answers

In pharmacokinetics, what does the term 'absorption' refer to?

<p>The movement of a drug from the site of administration into the bloodstream. (A)</p> Signup and view all the answers

What is a characteristic of intravenous drug administration?

<p>It guarantees 100% bioavailability immediately upon injection. (C)</p> Signup and view all the answers

What distinguishes intramuscular injections from subcutaneous injections?

<p>IM injections are absorbed faster due to greater blood supply (C)</p> Signup and view all the answers

Which of the following is a potential risk when injecting parenteral drugs?

<p>The drug can be incorrectly administered and cause immediate effects. (B)</p> Signup and view all the answers

Which of the following is true about depot drugs administered intramuscularly?

<p>They are designed for slow absorption over time (D)</p> Signup and view all the answers

In which situation should the route of administration for a medication NOT be changed?

<p>If the prescriber has not stipulated a route change (D)</p> Signup and view all the answers

What type of dosage form must not be crushed due to its coating?

<p>Enteric-coated tablets (B)</p> Signup and view all the answers

What is a likely complication of using topical drug administration?

<p>Erratic and unreliable systemic absorption (D)</p> Signup and view all the answers

Why do orally administered drugs often have bioavailability less than 100%?

<p>They often undergo extensive first-pass metabolism in the liver. (D)</p> Signup and view all the answers

What type of absorption is seen with rectal administration of medications?

<p>Mixed first-pass and non-first-pass absorption (A)</p> Signup and view all the answers

What characteristic of topical medications affects their systemic absorption?

<p>Their systemic absorption is typically erratic (D)</p> Signup and view all the answers

Why should one be cautious when using nasal sprays?

<p>They provide both local and systemic effects (B)</p> Signup and view all the answers

Which of these routes of drug administration avoids the first-pass effect?

<p>Intravenous route (A)</p> Signup and view all the answers

Which route is typically used for medications that require long-term, steady administration?

<p>Intramuscular depot injections (B)</p> Signup and view all the answers

What is a significant risk associated with drug absorption influenced by insufficient blood flow?

<p>Delayed drug activity (C)</p> Signup and view all the answers

Which of the following is NOT an example of a parenteral route?

<p>Oral administration (D)</p> Signup and view all the answers

What is bioequivalence in the context of drug products?

<p>When two drugs have the same bioavailability and concentration of active ingredient. (B)</p> Signup and view all the answers

Which organ is primarily responsible for the elimination of drugs from the body?

<p>Kidney (B)</p> Signup and view all the answers

Which route of administration results in the fastest absorption of drugs?

<p>Parenteral (A)</p> Signup and view all the answers

Which form of nitroglycerin provides immediate action for a patient experiencing chest pain?

<p>Intravenous infusion (A), Sublingual dose (C)</p> Signup and view all the answers

What process primarily allows for the elimination of free water-soluble drugs from the kidneys?

<p>Passive glomerular filtration (D)</p> Signup and view all the answers

What effect does first-pass metabolism have on drug absorption?

<p>It reduces the amount of drug that enters systemic circulation. (C)</p> Signup and view all the answers

What is the fate of drugs that undergo enterohepatic recirculation?

<p>They persist in the body for a longer time. (D)</p> Signup and view all the answers

Which factors can alter the absorption of drugs taken orally?

<p>Blood flow to the gastrointestinal tract. (A)</p> Signup and view all the answers

What is drug half-life defined as?

<p>The time required for half of a drug to be eliminated. (B)</p> Signup and view all the answers

What happens when Mrs. A chews her extended-release nitroglycerin tablet?

<p>It turns the drug into an immediate-release formulation. (A)</p> Signup and view all the answers

After how many half-lives is a drug typically considered effectively removed from the body?

<p>Four to five half-lives (A)</p> Signup and view all the answers

Which route of drug administration can be affected by gastric dumping syndrome?

<p>Oral (C)</p> Signup and view all the answers

Why are drugs usually metabolized in the liver before reaching the kidneys?

<p>To increase their polarity and water solubility (A)</p> Signup and view all the answers

What signifies the steady state in drug pharmacokinetics?

<p>Absorption equals elimination (D)</p> Signup and view all the answers

How might the presence of food alter drug absorption for fat-soluble drugs?

<p>Food enhances absorption of fat-soluble drugs. (C)</p> Signup and view all the answers

What is the purpose of enteric coating on medications?

<p>To protect the drug from being dissolved in the acidic stomach environment. (D)</p> Signup and view all the answers

What does the peak effect of a drug refer to?

<p>The maximum therapeutic response of the drug (C)</p> Signup and view all the answers

Sublingual and buccal routes of drug administration are characterized by which feature?

<p>Rapid absorption into the bloodstream. (C)</p> Signup and view all the answers

Which of the following is NOT a route of drug elimination?

<p>Nervous system (C)</p> Signup and view all the answers

What happens to the concentration of a drug in the body as it is eliminated?

<p>It decreases logarithmically. (A)</p> Signup and view all the answers

What is the impact of anticholinergic drugs on gastrointestinal transit time?

<p>They slow down GI transit time. (D)</p> Signup and view all the answers

What might occur if the peak blood level of a drug is too high?

<p>Drug toxicity might occur. (B)</p> Signup and view all the answers

Which of the following medications should be taken on an empty stomach?

<p>Alendronate sodium (C)</p> Signup and view all the answers

In terms of drug delivery, which of the following is NOT considered a parenteral route?

<p>Sublingual (C)</p> Signup and view all the answers

What term describes the physiologic reactions of the body in response to a drug?

<p>Drug effects (D)</p> Signup and view all the answers

What would likely occur if the trough blood level of a drug is too low?

<p>Therapeutic effects may be inadequate. (B)</p> Signup and view all the answers

Why might the absorption of drugs be decreased in a patient experiencing sepsis?

<p>Reduced blood flow to the gastrointestinal area. (D)</p> Signup and view all the answers

Which type of therapy aims to prevent the progression of a disease or condition?

<p>Maintenance therapy (B)</p> Signup and view all the answers

What therapy is commonly used for conditions in the end stages of illness?

<p>Palliative therapy (A)</p> Signup and view all the answers

Which type of therapy is given to provide the body with a substance it can't produce or produce in sufficient quantities?

<p>Supplemental therapy (A)</p> Signup and view all the answers

What type of therapy is administered before a surgical procedure to prevent infections?

<p>Prophylactic therapy (D)</p> Signup and view all the answers

Which best describes empirical therapy?

<p>Therapy based on the most likely cause of illness (B)</p> Signup and view all the answers

A patient with newly diagnosed cancer receiving chemotherapy is an example of which type of therapy?

<p>Acute therapy (A)</p> Signup and view all the answers

What type of therapy is used to maintain blood pressure within given limits to prevent end-organ damage?

<p>Maintenance therapy (A)</p> Signup and view all the answers

What is the primary goal of palliative therapy?

<p>To provide comfort and symptom relief (D)</p> Signup and view all the answers

Which of the following is NOT an example of supportive therapy?

<p>Administering pain medication to reduce discomfort (D)</p> Signup and view all the answers

What is the therapeutic index of a drug?

<p>The difference between a therapeutic dose and a toxic dose (C)</p> Signup and view all the answers

Why is monitoring a patient's response to medication important?

<p>To identify any potential adverse effects of the medication (C)</p> Signup and view all the answers

How can drug accumulation occur?

<p>When a drug is eliminated too slowly (B)</p> Signup and view all the answers

What does a low therapeutic index indicate about a drug?

<p>The drug is more likely to cause adverse reactions (B)</p> Signup and view all the answers

Which of the following is considered a drug with a low therapeutic index?

<p>Warfarin (A)</p> Signup and view all the answers

Why are drug concentrations in the blood important?

<p>To evaluate the effectiveness of therapy (A)</p> Signup and view all the answers

What type of therapy aims to provide comfort and relief from symptoms associated with a serious illness?

<p>Palliative therapy (A)</p> Signup and view all the answers

What is a potential consequence of two highly protein-bound medications competing for binding sites?

<p>More free or unbound drug (C)</p> Signup and view all the answers

What term describes the biochemical alteration of a drug into an inactive or less active metabolite?

<p>Biotransformation (D)</p> Signup and view all the answers

Which of the following describes a drug that is hydrophilic?

<p>It is easily excreted (C)</p> Signup and view all the answers

Which organ is primarily responsible for drug metabolism?

<p>Liver (B)</p> Signup and view all the answers

What characteristic do lipophilic drugs typically have concerning volume of distribution?

<p>They have minimal blood concentrations (D)</p> Signup and view all the answers

What is the role of cytochrome P-450 enzymes in drug metabolism?

<p>They facilitate the metabolism of lipophilic drugs. (B)</p> Signup and view all the answers

What would be the likely effect of an enzyme inhibitor on drug metabolism?

<p>Accumulation of the drug in the body (D)</p> Signup and view all the answers

What is indicated when a drug is described as a substrate for cytochrome P-450 enzymes?

<p>It is metabolized by specific P-450 enzymes. (D)</p> Signup and view all the answers

Which of the following can influence the metabolism of drugs?

<p>Patient's genetic constitution (A)</p> Signup and view all the answers

What typically results from repeated administration of enzyme inducers?

<p>Enhanced formation of metabolizing enzymes (D)</p> Signup and view all the answers

What is the primary effect of a poor blood supply on drug distribution?

<p>Decreased distribution to certain body sites (C)</p> Signup and view all the answers

What is the main function of P-glycoprotein in drug interactions?

<p>It acts as a drug transport mechanism out of the cell. (B)</p> Signup and view all the answers

Which form of biotransformation typically results in a more water-soluble compound?

<p>Oxidation (D)</p> Signup and view all the answers

What is a primary advantage of using transdermal patches for drug delivery?

<p>Deliver a constant amount of drug over a specified time (D)</p> Signup and view all the answers

Inhaled drugs need to be in micrometer-sized particles because they must reach which part of the lungs?

<p>Alveoli (A)</p> Signup and view all the answers

What is a disadvantage of intravenous (IV) drug administration?

<p>Inability to retrieve medication after administration (B)</p> Signup and view all the answers

Which route of administration is indicated for drugs that are poorly soluble and require prolonged absorption?

<p>Intramuscular (B)</p> Signup and view all the answers

Why are inhaled drugs effective for treating pulmonary diseases?

<p>They are delivered directly to lung tissue. (C)</p> Signup and view all the answers

What nursing consideration is crucial when administering intravenous (IV) medications?

<p>Monitor the IV site for complications. (D)</p> Signup and view all the answers

What is a necessary consideration when administering oral medications through a nasogastric tube?

<p>The tube must be flushed before and after medication administration. (D)</p> Signup and view all the answers

What gauge needle is generally recommended for intramuscular (IM) injections?

<p>18-20 gauge (A)</p> Signup and view all the answers

Which type of drug formulation is likely to be ineffective when taken orally due to gastrointestinal variables?

<p>Enteric-coated pills (C)</p> Signup and view all the answers

Which of the following statements regarding subcutaneous (SUBQ) injections is correct?

<p>The typical needle size for SUBQ injections is ½ to 1 inch. (C)</p> Signup and view all the answers

Which route is associated with the lowest risk of needlestick injury?

<p>Transdermal (C)</p> Signup and view all the answers

What is a characteristic of drugs administered via the oral route?

<p>Tend to have variable absorption rates. (D)</p> Signup and view all the answers

Why is it important to select the correct syringe size for injections?

<p>To ensure safe administration based on drug characteristics. (B)</p> Signup and view all the answers

What is a disadvantage of intramuscular and subcutaneous administration compared to intravenous administration?

<p>Slower onset of action (A)</p> Signup and view all the answers

What term is used for the concentration level at which a drug starts to have an effect?

<p>Minimal effective concentration (C)</p> Signup and view all the answers

How do drugs typically interact with receptors to produce a pharmacologic response?

<p>By binding to and forming chemical bonds with receptors (B)</p> Signup and view all the answers

What does the term 'affinity' refer to in drug-receptor interactions?

<p>The strength of the bond between a drug and its receptor (B)</p> Signup and view all the answers

Which type of drug binds to a receptor but does not produce a response?

<p>Antagonist (C)</p> Signup and view all the answers

What is the primary role of enzymes in drug action?

<p>To catalyze biochemical reactions and facilitate drug effects (B)</p> Signup and view all the answers

Nonselective interactions of drugs primarily target which cellular components?

<p>Cell membranes and metabolic processes (A)</p> Signup and view all the answers

For effective drug therapy, how should therapeutic outcomes be established?

<p>In consultation with the patient and health care team (C)</p> Signup and view all the answers

What is the consequence of a drug that acts as a competitive antagonist?

<p>It binds to the receptor and prevents agonist binding. (D)</p> Signup and view all the answers

Which step is crucial before initiating drug therapy?

<p>Establishing a realistic outcome or endpoint (C)</p> Signup and view all the answers

What distinguishes a partial agonist from a full agonist?

<p>It produces a diminished response compared to a full agonist. (A)</p> Signup and view all the answers

What does a noncompetitive antagonist do at the receptor site?

<p>It prevents any response by inactivating the receptor. (C)</p> Signup and view all the answers

What is the commonly accepted goal of drug therapy?

<p>To achieve a therapeutic effect in a faulty physiologic system (B)</p> Signup and view all the answers

What can result from the combination of warfarin and amiodarone?

<p>Increased risk of toxicity from both drugs (D)</p> Signup and view all the answers

What is a potential outcome of metabolic competition between erythromycin and cyclosporine?

<p>Elevated toxic levels of cyclosporine (D)</p> Signup and view all the answers

How does probenecid affect amoxicillin levels in the body?

<p>Inhibits its secretion into the kidneys (D)</p> Signup and view all the answers

What characterizes an adverse drug event (ADE)?

<p>Can result from internal patient-induced actions (D)</p> Signup and view all the answers

Which type of adverse event is classified as preventable?

<p>Medication errors (A)</p> Signup and view all the answers

What is an adverse drug reaction (ADR)?

<p>An unexpected and undesirable response at therapeutic dosages (D)</p> Signup and view all the answers

Which describes a pharmacologic reaction?

<p>An expected outcome exceeding normal medication effects (C)</p> Signup and view all the answers

What is a key characteristic of hypersensitivity reactions?

<p>They involve the immune system's response (B)</p> Signup and view all the answers

What is a common cause of medication errors?

<p>Misidentification of the drug being administered (A)</p> Signup and view all the answers

What might a severe allergic reaction lead to?

<p>Anaphylactic shock requiring emergency intervention (C)</p> Signup and view all the answers

What is a potential adverse consequence of stopping antibiotic therapy too soon?

<p>Return of the original infection (A)</p> Signup and view all the answers

Which of the following could be classified as a potential ADE?

<p>A noticed issue before it actually leads to patient harm (B)</p> Signup and view all the answers

What defines an adverse drug withdrawal event?

<p>Complications that arise from abruptly stopping medication (A)</p> Signup and view all the answers

What is the primary consequence of impaired liver or kidney function regarding drug levels in the body?

<p>Increased risk of toxic drug levels (A)</p> Signup and view all the answers

Which factor is NOT considered when assessing a patient's response to drug therapy?

<p>Patient's age (C)</p> Signup and view all the answers

How does tolerance differ from dependence in the context of drug use?

<p>Tolerance refers to increased dosage requirement; dependence involves withdrawal symptoms. (D)</p> Signup and view all the answers

What is a common result of drug interactions caused by competition for metabolizing enzymes?

<p>Decreased metabolism of one or both drugs (C)</p> Signup and view all the answers

What is referred to as an antagonistic effect in drug interactions?

<p>The combination of two drugs results in less effect than expected. (B)</p> Signup and view all the answers

What is the effect of consuming dairy products while taking tetracycline antibiotics?

<p>Chemical binding of the drug leading to decreased effectiveness (B)</p> Signup and view all the answers

Which of the following substances is known to cause a hypertensive crisis when taken with monoamine oxidase inhibitors?

<p>Aged cheese and wine (D)</p> Signup and view all the answers

What does the term 'drug incompatibility' typically refer to?

<p>Physical or chemical reactions between medications (C)</p> Signup and view all the answers

Which psychological factor is known to significantly affect a patient's response to drug therapy?

<p>Stress and anxiety levels (A)</p> Signup and view all the answers

What occurs during the absorption phase when antacids are administered with levofloxacin?

<p>Decreased absorption due to binding (B)</p> Signup and view all the answers

Which of the following categories of drugs is most likely to cause significant interactions with over-the-counter medications?

<p>Antihypertensives (A)</p> Signup and view all the answers

Which term best describes the effect where two drugs given together produce a combined effect that is greater than the sum of their effects when given separately?

<p>Synergistic effect (B)</p> Signup and view all the answers

What impact can the use of herbal therapies have on prescribed medications?

<p>May alter therapeutic effects and lead to interactions (C)</p> Signup and view all the answers

What is an important consideration in patients receiving multiple medications regarding drug interactions?

<p>They have an increased likelihood of drug interactions. (C)</p> Signup and view all the answers

Flashcards

Pharmacology

The study or science of drugs, covering topics like absorption, metabolism, distribution, and effects on the body.

Chemical Name

The name given to a drug based on its chemical composition and structure.

Generic Name

The official, non-proprietary name of a drug, often shorter and simpler than the chemical name.

Trade Name

The registered trademark name given to a drug by the manufacturer, often catchy and memorable.

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Patent Life

The period of time a drug's patent is valid, usually 17 years.

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Biosimilars

Drugs that are similar to biological products, but not exact copies.

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Pharmacokinetics

The process by which a drug is absorbed, distributed, metabolized, and excreted by the body.

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Pharmacodynamics

The study of how drugs interact with the body to produce their effects.

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Therapeutic equivalence

A drug's ability to be replaced with another drug that has the same therapeutic effect, despite differences in their active ingredients.

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Drug classification

A classification system that groups drugs based on their similar properties, like structure or therapeutic use.

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Prototypical drug

The first drug in a class of drugs that serves as a benchmark and is often used as a reference point.

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Pharmaceutics

The study of how different drug formulations affect their absorption and action in the body.

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Pharmacotherapeutics

The clinical use of drugs to prevent and treat diseases, encompassing understanding drug actions and their principles.

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Off-label prescribing

Prescribing a drug for a use that has not been officially approved by regulatory agencies like the FDA.

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Toxicology

The study of the adverse effects of drugs and other chemicals on living systems.

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Pharmacognosy

The study of natural drug sources, including plants, animals, and minerals.

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Pharmacoeconomics

The study of the economic aspects of drug therapy, including cost-effectiveness and resource allocation.

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Drug dissolution

The process of a solid dosage form dissolving and becoming absorbed in the body.

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Enteric-coated tablets

Tablets or capsules that are coated to prevent dissolution in the stomach and are absorbed in the intestines.

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Combination dosage forms

Dosage forms that contain multiple drugs in a single dose.

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Time to onset of action

The rate at which a drug reaches its maximum concentration in the body.

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Dosage Forms

Drug delivery systems designed to achieve desired therapeutic effects with minimal side effects.

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Enteral Route

A method of drug administration that involves the drug being swallowed and absorbed through the digestive tract.

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Parenteral Route

A method of drug administration that involves injecting the drug directly into the body tissue.

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Topical Route

A method of drug administration where the drug is applied directly to the skin or mucous membranes.

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Extended-Release Dosage Form

A type of dosage form that releases the drug gradually over an extended period of time.

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Immediate-Release Dosage Form

A type of dosage form that releases the drug immediately upon dissolution in the digestive tract.

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Orally Disintegrating Tablets

A type of dosage form that dissolves in the mouth and is absorbed through the oral mucosa.

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Absorption

The movement of a drug from its site of administration into the bloodstream for distribution to the tissues.

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Bioavailability

The extent to which a drug is absorbed into the bloodstream.

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First-Pass Effect

The first pass effect refers to the metabolism of a drug by the liver before it reaches systemic circulation.

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Excretion

The process of removing a drug and its metabolites from the body.

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Metabolism

The process of breaking down a drug into smaller molecules in the body.

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Distribution

The distribution of a drug throughout the body.

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Drug Metabolism

The process of chemically modifying a drug in the body.

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Bioequivalence

Two drug products are considered bioequivalent if they have the same bioavailability and the same concentration of the active ingredient.

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Drug Absorption

The process by which a drug enters the bloodstream and reaches the site of action, influenced by its route of administration, formulation, and other factors.

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Orally Administered Drugs

Drugs that are absorbed through the lining of the stomach or intestines.

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Enteric Coating

A coating on medications designed to protect the stomach by releasing the drug in the intestines, where it is absorbed.

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Acid-Susceptible Drugs

A specialized coating on some medications that allows them to be dissolved and absorbed in the intestines, protecting the stomach from irritation.

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Sublingual Administration

Drugs that are rapidly absorbed through the highly vascularized tissue under the tongue.

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Buccal Administration

Drugs that are absorbed through the oral mucosa between the cheek and the gum.

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GI Transit Time

The time it takes for substances in the stomach to be dissolved and transported to the intestines for absorption.

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Gastric Dumping

The condition where medication absorption is altered due to the rapid delivery of stomach contents to the intestines, often after bariatric surgery.

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Reduced Blood Flow to GI Tract

A condition characterized by reduced blood flow to the GI tract, potentially affecting drug absorption.

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What does 'parenteral' mean in drug administration?

A general term encompassing all drug administration methods excluding the GI tract.

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What is intravenous (IV) administration?

Directly injecting medication into the bloodstream, bypassing the GI tract and reaching the intended site of action quickly.

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What is subcutaneous injection?

Injecting medication into the fatty tissues beneath the skin, resulting in slower absorption compared to IV.

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What is intramuscular (IM) injection?

Injecting medication into the muscles, allowing for faster absorption than subcutaneous due to greater blood supply.

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What is an intradermal injection?

Administering medication directly into the dermal layer, typically used for skin testing or local effects.

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What is the topical route of drug administration?

Medication delivered through various body surfaces like skin, eyes, ears, nose, lungs, rectum, or vagina.

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What is the transdermal route?

A specialized topical route where medication is absorbed through adhesive patches, allowing for steady and controlled delivery.

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What is rectal administration?

Administering medication through the rectum, a route that bypasses the stomach and partially the liver.

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What is the first-pass effect?

The process where a drug's concentration is reduced as it passes through the liver before entering the general circulation.

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What are depot drugs?

A drug that is formulated to release its medication slowly over an extended period, often days to months.

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Does IV equal PO?

A term used to describe drug formulations that are available in both intravenous (IV) and oral (PO) forms.

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What is the time until onset of action?

The time it takes for a drug to reach its maximum effect in the body.

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What is off-label prescribing?

When a physician prescribes a drug for a purpose other than what it's FDA-approved for.

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What is pharmacokinetics?

The study of how drugs affect the body in terms of absorption, distribution, metabolism, and excretion.

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What is pharmacodynamics?

The study of how drugs interact with the body to produce their effects.

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Sublingual Route

Drug administration method where the drug is placed under the tongue and absorbed directly into the bloodstream.

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Buccal Route

Drug administration method where the drug is placed between the cheek and gum and absorbed into the bloodstream.

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Rectal Route

Drug administration method where the drug is inserted into the rectum and absorbed into the bloodstream.

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Transdermal Route

A type of topical drug administration where the drug is absorbed through the skin via a patch.

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Inhalational Route

Drug administration method where the drug is inhaled into the lungs.

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Drug Excretion

The process of removing a drug and its metabolites from the body.

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Drug Distribution

The transport of a drug by the bloodstream to its site of action.

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Albumin

The protein in the blood that carries many drugs.

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Free Drug

The pharmacologically active portion of a drug that is not bound to plasma proteins.

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Bound Drug

The portion of a drug that is bound to plasma proteins and is pharmacologically inactive.

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Fentanyl patch

A common example of a transdermal patch used for pain relief.

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Inhalation

A topical drug delivery method that involves inhaling medication particles that are tiny enough to reach the lungs.

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Micrometer-sized drug particles

Tiny particles of medication, suitable for inhalation, allowing drug absorption in the lungs.

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Alveoli

The small air sacs in the lungs where inhaled medication is absorbed.

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Intravenous (IV) route

Administration of medication directly into a vein, providing rapid drug delivery into the bloodstream.

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Thrombophlebitis

A potential complication of IV administration where a blood clot forms in a vein.

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Infiltration

A potential complication of IV administration where fluid leaks out of the vein into surrounding tissue.

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Intramuscular (IM) route

A potential complication of IV administration where medication is injected into the muscle, providing slower absorption compared to IV.

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Damage to blood vessels or nerves

A potential complication of IM administration where a needle damages a nerve or blood vessel.

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Subcutaneous (SUBQ) route

Administration of medication under the skin, providing slower absorption than IV but faster than oral.

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Drug Irritability

A potential complication of SUBQ administration where the drug irritates the tissue around the injection site.

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Oral (PO) route

Administration of medication by mouth, providing the easiest and most convenient route but with variable absorption.

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What is the primary organ for drug elimination?

The primary organ responsible for eliminating drugs from the body.

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What is metabolism?

The process by which drugs are broken down into smaller molecules in the body.

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What is half-life?

The time it takes for half of a drug to be eliminated from the body.

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What is steady state?

The state where the amount of drug entering the body equals the amount being eliminated.

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What is the onset of action?

The time it takes for a drug to start having its therapeutic effect.

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What is the peak effect?

The time it takes for a drug to reach its maximum therapeutic effect.

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What is the duration of action?

The length of time a drug concentration is sufficient to produce a therapeutic effect.

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What is the peak level?

The highest concentration of a drug in the blood after administration.

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What is the trough level?

The lowest concentration of a drug in the blood between doses.

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What is biliary excretion?

The process of removing drugs from the body through the intestines.

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What is enterohepatic recirculation?

The process where a drug is absorbed into the bloodstream, returned to the liver, and secreted again into the bile.

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What is glomerular filtration?

The process by which free drugs and metabolites are filtered through the glomerulus.

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What is tubular reabsorption?

The process by which substances in the nephrons are reabsorbed back into the bloodstream.

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What is tubular secretion?

The process by which substances are secreted into the nephrons from the surrounding vasculature.

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How are drugs excreted by the intestines?

The process by which drugs are taken up by the liver, released into the bile, and eliminated in the feces.

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Protein Binding Competition

When two drugs compete for the same binding sites on albumin, a protein in the blood. This can lead to more free drug in the bloodstream because fewer molecules are bound.

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Volume of Distribution

A theoretical volume used to describe how a drug distributes in the body - where it goes and in what concentrations.

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Cytochrome P-450 Enzymes

Enzymes that are involved in the metabolism of many drugs, particularly those that are fat-soluble.

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Drug-Drug Interaction

When the presence of one drug alters the effects of another drug that is taken at the same time.

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Enzyme Inducers

Drugs that increase the activity of drug-metabolizing enzymes, often leading to faster drug breakdown and shorter effects.

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Enzyme Inhibitors

Drugs that decrease the activity of drug-metabolizing enzymes, often causing drugs to break down slower, leading to higher levels and longer effects.

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P-glycoprotein

A protein found in the cell membrane that acts like a pump, transporting drugs out of the cell.

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Therapeutic Effect

The desired, positive change in a faulty system that a drug is intended to produce.

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Receptor

The specific molecule or structure on a cell that a drug binds to, causing a physiological response.

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Affinity

The degree to which a drug binds and interacts with a receptor, determining the strength of its effect.

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Agonist

A drug that binds to a receptor and elicits a response, producing the desired effect.

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Antagonist

A drug that binds to a receptor but does not elicit a response, instead blocking the action of other drugs.

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Nonselective Interactions

Drugs that act by altering cell membranes or interfering with metabolic processes, not through specific receptor or enzyme interactions.

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Therapeutic Outcome

The pre-determined goal or outcome of drug therapy, tailored to each patient's specific needs and health status.

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Patient Therapy Assessment

The process of evaluating a patient's medical history, current medications, and potential risks before starting a drug regimen.

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Contraindication

Any patient condition or factor that makes a particular drug dangerous or inappropriate to administer.

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Drug Monitoring

The process of monitoring a patient's response to drug therapy, including the effectiveness and any side effects.

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Therapeutic Response Assessment

An assessment of the patient's response to drug therapy, focusing on effectiveness, safety, and any adverse effects.

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Drug Monitoring

The process of monitoring a patient's response to drug therapy, including the effectiveness and any side effects.

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Acute Therapy

A type of therapy used for patients who are acutely ill, often involving intensive drug treatment to sustain life or treat disease.

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Maintenance Therapy

A type of therapy that aims to prevent progression of a disease or condition, but does not eradicate existing problems.

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Supplemental Therapy

Therapy that provides the body with substances it cannot produce or produces in insufficient quantities to maintain normal function.

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Palliative Therapy

Therapy focused on providing comfort and symptom relief for patients with serious illness, especially when curative treatment is not possible.

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Supportive Therapy

Therapy that supports the body's functions during recovery from illness or trauma, helping the patient maintain stability.

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Prophylactic Therapy

Therapy used to prevent illness or undesirable outcomes before they occur, often during planned events.

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Empirical Therapy

Therapy based on clinical probabilities, involving drug administration when a specific condition is highly likely based on symptoms.

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Monitoring

The process of evaluating the effectiveness of therapy by observing a patient's clinical response to treatment.

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Therapeutic Index

The ratio of a drug's toxic level to the level that provides therapeutic benefits, determining the drug's safety.

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Drug Concentration

The concentration of a drug in the blood, which can be used to evaluate clinical response and identify potential risks.

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Idiosyncratic Drug Reaction

An unexpected, individual reaction to a drug, not related to known properties or allergies. It's usually caused by a genetic difference in drug metabolism.

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Pharmacogenomics

The study of how drug effects vary between individuals, often due to genetic differences.

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Drug Interaction

When two or more drugs interact within the body, resulting in an unwanted effect. The effect can be enhanced or reduced.

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Drug-Metabolizing Enzyme Deficiency/Excess

A deficiency or excess of specific enzymes involved in drug metabolism, leading to unusual reactions.

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Drug Interaction: Enhancement or Reduction

A type of drug interaction where the presence of one drug alters the effect of another.

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Depot Drugs

A drug that is formulated to release its medication slowly over an extended period, often days to months.

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Additive Effect

A drug interaction that occurs when two drugs with similar actions are given together, resulting in an effect that is the sum of the individual effects.

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Synergistic Effect

A drug interaction that occurs when two drugs administered together result in an effect that is greater than the sum of the effects for each drug given alone.

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Antagonistic Effect

A drug interaction that occurs when two drugs administered together have an effect that is less than the sum of the effects for each drug given separately.

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Tolerance

A decreasing response to repeated drug doses.

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Dependence

A physiologic or psychological need for a drug to avoid withdrawal symptoms.

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Drug Incompatibility

When substances or medications are mixed together and result in a chemical deterioration or formation of a physical precipitate.

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Potency

A measure of the drug's strength, referring to the amount of drug needed to produce a therapeutic effect.

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Adverse Drug Reaction (ADR)

A reaction to a drug that is unexpected and undesirable, happening at therapeutic dosages.

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Adverse Drug Event (ADE)

An event involving medication that has an undesirable outcome, ranging from mild to life-threatening.

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Medication Error

A type of ADE that is preventable, occurring due to errors in medication use.

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Potential ADE

An event that is noticed before it actually occurs, preventing potential harm.

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Pharmacologic ADR

A reaction due to the normal effects of a drug being exaggerated, like blood pressure dropping too low with a blood pressure medication.

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Hypersensitivity (Allergic) Reaction

A reaction triggered by the patient's immune system, often involving antibodies recognizing the drug as a foreign substance.

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Idiosyncratic Reaction

A reaction that cannot be explained by normal drug actions or hypersensitivity, often unpredictable.

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Study Notes

Drug Pharmacology

  • Drugs are chemical substances that affect the physiological processes of living organisms.
  • Pharmacology is the study of drugs.
  • Drug study encompasses various aspects, including absorption, biochemical effects, biotransformation, distribution, drug origins, history, excretion, mechanisms of action, physical and chemical properties, physical effects, drug receptor mechanisms, therapeutic, and toxic effects.

Drug Names and Categorization

  • Drugs have three names: chemical, generic (non-proprietary), and trade (proprietary).
  • Chemical names precisely describe molecular structure.
  • Generic names are shorter and used in official drug lists.
  • Trade names are patented, registered trademarks, often optimized for marketability.
  • Biosimilars are copies of authorized biological products.
  • Drugs are categorized by similar properties (drug classification).

Drug Dosage Forms

  • Dosage forms (tablets, capsules, liquids) influence absorption rate.
  • Liquid forms dissolve and absorb faster than solid forms.
  • Enteric-coated tablets dissolve in the intestines.
  • Particle size can affect dissolution and absorption rates.
  • Combination dosage forms contain multiple drugs in one dose (e.g., Caduet).
  • Extended-release forms (SR, SA, CR, XL, XT) release drugs over time; they shouldn't be crushed.
  • Orally disintegrating tablets dissolve in the mouth.

Pharmacokinetics

  • Pharmacokinetics describes what the body does to a drug.
  • Stages include absorption, distribution, metabolism (biotransformation), and excretion.
  • Absorption moves drug into bloodstream; bioavailability expresses absorption extent.
  • Drugs absorbed from the intestines must pass the liver (first-pass effect).
  • IV drugs have 100% bioavailability.
  • Bioequivalence means similar bioavailability and active ingredient concentration.
  • Factors affecting absorption: administration route, dosage form.

Drug Routes of Administration

  • Enteral: drugs absorbed through the GI tract (oral, rectal).
  • Parenteral: drugs not via the GI tract (injection).
  • Topical: drugs applied to skin or other body surfaces.
  • Sublingual/buccal: rapid absorption under or between tongue/cheek.
  • Transdermal: constant drug release through skin patches.
  • Inhaled: drug delivery directly into lungs.

Distribution

  • Distribution is drug transport to the site of action via bloodstream.
  • Drugs first reach areas with high blood supply (heart, liver, kidneys, brain).
  • Only unbound drug molecules can distribute to tissues.
  • Albumin is the primary protein binding drug, some conditions (burns, malnutrition) can increase risk of drug toxicity.
  • Competition for binding sites possible resulting in drug-drug interactions.
  • Volume of distribution describes drug distribution in various body compartments.

Metabolism

  • Metabolism (biotransformation) chemically alters drugs.
  • Liver is the primary organ for drug metabolism.
  • P450 enzymes are important for drug metabolism.
  • Drug substrates are molecules metabolized by specific enzymes.
  • Some drugs can inhibit or induce drug-metabolizing enzymes potentially resulting in drug-drug interactions.
  • Variability in metabolism from patient to patient based on genes, diseases, and other medications.

Excretion

  • Excretion is removal of drugs from the body. Kidneys are the primary organ.
  • Liver and intestines also excrete drugs (biliary excretion).
  • Enterohepatic recirculation prolongs drug duration in the body.
  • Half-life is the time for 50% of a drug to be eliminated; reaching a steady state.

Pharmacodynamics

  • Pharmacodynamics describes a drug's effect on the body.
  • Mechanisms include receptor interactions, enzyme interactions, and nonspecific interactions.
  • Agonists, antagonists and partial agonists are different types of interactions.
  • Receptor interactions are drug interactions with receptors on or within cells.
  • Drug effects are the body's physiological response to a drug.
  • Drug effects (onset, peak, duration) impact clinical response.

Pharmacotherapeutics

  • Pharmacotherapeutics is the clinical use of drugs to treat diseases.
  • Patient-specific goals and outcomes are established pre-therapy
  • Types of drug therapy (acute, maintenance, supplemental, palliative, supportive, prophylactic, and empirical).
  • Monitoring of therapeutic and adverse effects following therapy.
  • Recognizing potential drug toxicity.

Adverse Drug Events and Drug Interactions

  • Adverse Drug Events (ADEs) are undesirable drug-related outcomes.
  • Medication errors and adverse drug reactions (ADRs) are types of ADEs.
  • Pharmacologic, hypersensitivity (allergic), idiosyncratic reactions, and drug interactions are different types of ADRs.
  • Drug interactions can occur between drugs, food and other agents; some interactions are beneficial.
  • Factors like concurrent diseases, tolerance, dependence can affect drug response.
  • Therapeutic index quantifies a drug's safety (low = greater risk of overdose).
  • Drug concentrations are important for assessing treatment success and minimizing toxicity.

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