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Questions and Answers
Which of the following are classified as H1 blockers?
Identify the correct pairings of eicosanoids and their classifications.
Which agents are classified as H2 blockers?
What type of agents are considered 5HT antagonists?
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Which of the following is commonly used as a synthesis inhibitor of eicosanoids?
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Which of these options correctly matches an antagonist with its corresponding receptor type?
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Which agents are classified as ACE inhibitors?
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Which of the following is an example of a leukotriene antagonist?
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Study Notes
Autocoids Overview
- Autocoids are biologically active substances that act like hormones and have localized effects.
- They include histamine, serotonin, eicosanoids, and others, playing crucial roles in various physiological functions.
Histamine
- Involved in allergic reactions, gastric acid secretion, and neurotransmission.
- Has two receptor types: H1 and H2.
H1 Blockers
- Medications used to treat allergies and motion sickness include:
- Diphenhydramine
- Chlorpheniramine
- Promethazine
- Cetirizine
- Loratadine
H2 Blockers
- Primarily used to reduce gastric acid secretion:
- Cimetidine
- Ranitidine
- Famotidine
Serotonin (5HT)
- Functions as a neurotransmitter and has various receptor types (1-7).
Serotonin Agonists
- Medications that activate serotonin receptors include:
- Sumatriptan (often used for migraines)
- Buspirone (an anxiolytic)
Serotonin Antagonists
- Blockers that inhibit serotonin activity:
- Cyproheptadine
- Ondansetron (used for preventing nausea)
Eicosanoids
- Comprise bioactive lipids involved in inflammation, immunity, and other biological processes.
Prostaglandins
- Analogs used for treating various conditions:
- Misoprostol (gastric protection)
- Dinoprostone (labor induction)
- Carboprost
Leukotrienes
- Mediators of inflammatory responses with therapeutic antagonists including:
- Montelukast (used for asthma)
- Zafirlukast
Thromboxanes
- Involved in platelet aggregation and blood clotting.
Synthesis Inhibitors
- Medications that inhibit eicosanoid production:
- Aspirin (reduces thromboxane synthesis)
- Indomethacin (anti-inflammatory)
- Paracetamol (analgesic/antipyretic)
- Low dose aspirin (for cardiovascular protection)
Lipooxygenase Inhibitors
- Zileuton is used specifically to inhibit leukotriene synthesis, aiding in asthma management.
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Description
Explore the fascinating world of autocoids and their antagonists in pharmacology. This quiz covers key concepts such as histamine receptors, H1 and H2 blockers, and the role of peptides and ACE inhibitors. Test your understanding and knowledge of these vital pharmacological agents.
