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Pharmacology: Anticoagulants and Thrombolytics

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Pharmacology: Anticoagulants and Thrombolytics

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Questions and Answers

What is the mechanism of action of Warfarin?

Activating vitamin K-dependent enzymes

Enhancing platelet aggregation

Inhibiting vitamin K epoxide reductase (correct)

Directly inhibiting clotting factor production

What is a Black Box Warning for Edoxaban?

Epidural or spinal hematoma with possible paralysis (correct)

Risk of nonadherence

Increased risk of stroke in valvular atrial fibrillation

Premature discontinuation may lead to thrombosis

What is a contraindication for Edoxaban?

Artificial heart valves

Valvular atrial fibrillation

DVT/PE prophylaxis

Active bleeding (correct)

What is the reversal agent for Edoxaban?

Andexanet-alfa (C) Signup and view all the answers

What is the goal INR range for Warfarin in DVT and PE?

2-3 (C) Signup and view all the answers

What is a contraindication for Warfarin?

Pregnancy (B) Signup and view all the answers

What is a drug interaction to avoid with Warfarin?

Fluconazole (B) Signup and view all the answers

What is a Black Box Warning for Edoxaban in patients with A-Fib?

Don't use in patients with A-Fib and CrCl > 95 mL (B) Signup and view all the answers

What is a side effect of Edoxaban?

Bleeding (A) Signup and view all the answers

What is a contraindication for Edoxaban in patients undergoing anesthesia?

Epidural or spinal anesthesia (A) Signup and view all the answers