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Pharmacology: Anticoagulants and Thrombolytics
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Pharmacology: Anticoagulants and Thrombolytics

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Questions and Answers

What is the mechanism of action of Warfarin?

  • Activating vitamin K-dependent enzymes
  • Enhancing platelet aggregation
  • Inhibiting vitamin K epoxide reductase (correct)
  • Directly inhibiting clotting factor production

    • What is a Black Box Warning for Edoxaban?

  • Epidural or spinal hematoma with possible paralysis (correct)
  • Risk of nonadherence
  • Increased risk of stroke in valvular atrial fibrillation
  • Premature discontinuation may lead to thrombosis

    • What is a contraindication for Edoxaban?

  • Artificial heart valves
  • Valvular atrial fibrillation
  • DVT/PE prophylaxis
  • Active bleeding (correct)

    • What is the reversal agent for Edoxaban?

    <p>Andexanet-alfa</p> Signup and view all the answers

    What is the goal INR range for Warfarin in DVT and PE?

    <p>2-3</p> Signup and view all the answers

    What is a contraindication for Warfarin?

    <p>Pregnancy</p> Signup and view all the answers

    What is a drug interaction to avoid with Warfarin?

    <p>Fluconazole</p> Signup and view all the answers

    What is a Black Box Warning for Edoxaban in patients with A-Fib?

    <p>Don't use in patients with A-Fib and CrCl &gt; 95 mL</p> Signup and view all the answers

    What is a side effect of Edoxaban?

    <p>Bleeding</p> Signup and view all the answers

    What is a contraindication for Edoxaban in patients undergoing anesthesia?

    <p>Epidural or spinal anesthesia</p> Signup and view all the answers

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