DM pt2
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Questions and Answers

What is the mechanism of action of biguanides like Metformin?

  • Activating AMP kinase and reducing gluconeogenesis (correct)
  • Blocking ATP-dependent K+ channels
  • Enhancing insulin release
  • Increasing intracellular Ca2+ levels

How do sulfonylurea drugs enhance insulin release?

  • Blocking ATP-dependent K+ channels (correct)
  • Activating AMP kinase
  • Inhibiting GLUT4 transporters
  • Decreasing intracellular Ca2+ levels

Which class of drugs does not increase weight due to improved insulin sensitivity at the peripheral level?

  • Amylin analogs
  • Biguanides (correct)
  • Alpha-glucosidase inhibitors
  • Thiazolidinediones

What is the primary target of biguanides like Metformin?

<p>Hepatic and renal gluconeogenesis (A)</p> Signup and view all the answers

How do Alpha-glucosidase inhibitors like Acarbose and Miglitol work?

<p>Delay absorption of postprandial glucose (B)</p> Signup and view all the answers

What is the main mechanism of action of Alpha-glucosidase inhibitors like Acarbose and Miglitol?

<p>Slow down the absorption of sugar (B)</p> Signup and view all the answers

Which side effect is commonly associated with the use of Alpha-glucosidase inhibitors?

<p>Flatulence (B)</p> Signup and view all the answers

What is the main target of Thiazolidinediones such as Rosiglitazone and Ploglitazone?

<p>Improve insulin resistance (D)</p> Signup and view all the answers

Which of the following describes the Incretin Effect related to insulin secretion?

<p>Oral glucose elicits higher insulin response than intravenous glucose (C)</p> Signup and view all the answers

What is the main mechanism of action of Thiazolidinediones (Rosiglitazone, Ploglitazone)?

<p>Reduce insulin resistance (D)</p> Signup and view all the answers

Which category of antidiabetic drugs is primarily used to target postprandial glucose levels?

<p>Alpha-glucosidase inhibitors (B)</p> Signup and view all the answers

What is the main effect of Thiazolidinediones on blood sugar levels?

<p>Target more on insulin resistance than blood sugar levels (B)</p> Signup and view all the answers

Which class of antidiabetic drugs works by inhibiting Dipeptidyl Peptidase-4 (DPP4)?

<p>DPP4 Inhibitors (B)</p> Signup and view all the answers

What is the main mechanism of action of insulin secretagogues?

<p>Promote closure of Potassium channels in pancreas B-cells (A)</p> Signup and view all the answers

Which class of drugs does Glipizide and Glimepiride belong to?

<p>Sulfonylureas (B)</p> Signup and view all the answers

What is a common side effect associated with insulin secretagogues?

<p>Hypoglycemia (D)</p> Signup and view all the answers

Which class of oral antidiabetic agents targets both fasting and postprandial blood glucose control?

<p>Biguanides (C)</p> Signup and view all the answers

What is the main function of Biguanides like Metformin?

<p>Decrease hepatic glucose production (D)</p> Signup and view all the answers

Which class of antidiabetic drugs is known to decrease beta-cell function over time?

<p>Sulfonylureas (D)</p> Signup and view all the answers

Which class of antidiabetic drugs exerts its effects by reducing hepatic glucose production?

<p>Thiazolidinediones (A)</p> Signup and view all the answers

'Incretin Modulators' refer to which class of antidiabetic drugs?

<p>Dipeptidyl Peptidase-4 (DPP4) Inhibitors (D)</p> Signup and view all the answers

What is the primary function of Amylin analogs such as Pramlin/de?

<p>Reduce appetite (D)</p> Signup and view all the answers

Which hormone contributes to glycemic control and osteogenesis?

<p>Amylin (C)</p> Signup and view all the answers

What is the main side effect associated with Amylin analogs?

<p>Hypoglycemia (A)</p> Signup and view all the answers

How does Glucagon-Like Peptide-1 Analog (GLP-1) function in the body?

<p>Produces satiety (A)</p> Signup and view all the answers

What is the duration of action for GLP-1 once it is released in the body?

<p>10 minutes (B)</p> Signup and view all the answers

Which receptor does GLP-1 act on in the body?

<p>G-protein-coupled receptor (GPCR) (A)</p> Signup and view all the answers

What is the main purpose of GLP-1 in the body?

<p>Produce satiety (C)</p> Signup and view all the answers

What is the role of Amylin in inhibiting more insulin release?

<p>Suppressing glucagon release (B)</p> Signup and view all the answers

What happens when GLP-1 is released in response to eating in individuals with diabetes?

<p>Its duration is very short. (B)</p> Signup and view all the answers

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