DM pt2
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Questions and Answers

What is the mechanism of action of biguanides like Metformin?

  • Activating AMP kinase and reducing gluconeogenesis (correct)
  • Blocking ATP-dependent K+ channels
  • Enhancing insulin release
  • Increasing intracellular Ca2+ levels
  • How do sulfonylurea drugs enhance insulin release?

  • Blocking ATP-dependent K+ channels (correct)
  • Activating AMP kinase
  • Inhibiting GLUT4 transporters
  • Decreasing intracellular Ca2+ levels
  • Which class of drugs does not increase weight due to improved insulin sensitivity at the peripheral level?

  • Amylin analogs
  • Biguanides (correct)
  • Alpha-glucosidase inhibitors
  • Thiazolidinediones
  • What is the primary target of biguanides like Metformin?

    <p>Hepatic and renal gluconeogenesis</p> Signup and view all the answers

    How do Alpha-glucosidase inhibitors like Acarbose and Miglitol work?

    <p>Delay absorption of postprandial glucose</p> Signup and view all the answers

    What is the main mechanism of action of Alpha-glucosidase inhibitors like Acarbose and Miglitol?

    <p>Slow down the absorption of sugar</p> Signup and view all the answers

    Which side effect is commonly associated with the use of Alpha-glucosidase inhibitors?

    <p>Flatulence</p> Signup and view all the answers

    What is the main target of Thiazolidinediones such as Rosiglitazone and Ploglitazone?

    <p>Improve insulin resistance</p> Signup and view all the answers

    Which of the following describes the Incretin Effect related to insulin secretion?

    <p>Oral glucose elicits higher insulin response than intravenous glucose</p> Signup and view all the answers

    What is the main mechanism of action of Thiazolidinediones (Rosiglitazone, Ploglitazone)?

    <p>Reduce insulin resistance</p> Signup and view all the answers

    Which category of antidiabetic drugs is primarily used to target postprandial glucose levels?

    <p>Alpha-glucosidase inhibitors</p> Signup and view all the answers

    What is the main effect of Thiazolidinediones on blood sugar levels?

    <p>Target more on insulin resistance than blood sugar levels</p> Signup and view all the answers

    Which class of antidiabetic drugs works by inhibiting Dipeptidyl Peptidase-4 (DPP4)?

    <p>DPP4 Inhibitors</p> Signup and view all the answers

    What is the main mechanism of action of insulin secretagogues?

    <p>Promote closure of Potassium channels in pancreas B-cells</p> Signup and view all the answers

    Which class of drugs does Glipizide and Glimepiride belong to?

    <p>Sulfonylureas</p> Signup and view all the answers

    What is a common side effect associated with insulin secretagogues?

    <p>Hypoglycemia</p> Signup and view all the answers

    Which class of oral antidiabetic agents targets both fasting and postprandial blood glucose control?

    <p>Biguanides</p> Signup and view all the answers

    What is the main function of Biguanides like Metformin?

    <p>Decrease hepatic glucose production</p> Signup and view all the answers

    Which class of antidiabetic drugs is known to decrease beta-cell function over time?

    <p>Sulfonylureas</p> Signup and view all the answers

    Which class of antidiabetic drugs exerts its effects by reducing hepatic glucose production?

    <p>Thiazolidinediones</p> Signup and view all the answers

    'Incretin Modulators' refer to which class of antidiabetic drugs?

    <p>Dipeptidyl Peptidase-4 (DPP4) Inhibitors</p> Signup and view all the answers

    What is the primary function of Amylin analogs such as Pramlin/de?

    <p>Reduce appetite</p> Signup and view all the answers

    Which hormone contributes to glycemic control and osteogenesis?

    <p>Amylin</p> Signup and view all the answers

    What is the main side effect associated with Amylin analogs?

    <p>Hypoglycemia</p> Signup and view all the answers

    How does Glucagon-Like Peptide-1 Analog (GLP-1) function in the body?

    <p>Produces satiety</p> Signup and view all the answers

    What is the duration of action for GLP-1 once it is released in the body?

    <p>10 minutes</p> Signup and view all the answers

    Which receptor does GLP-1 act on in the body?

    <p>G-protein-coupled receptor (GPCR)</p> Signup and view all the answers

    What is the main purpose of GLP-1 in the body?

    <p>Produce satiety</p> Signup and view all the answers

    What is the role of Amylin in inhibiting more insulin release?

    <p>Suppressing glucagon release</p> Signup and view all the answers

    What happens when GLP-1 is released in response to eating in individuals with diabetes?

    <p>Its duration is very short.</p> Signup and view all the answers

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