Pharmacology and Drug Interactions Quiz

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Questions and Answers

Which of the following is NOT a factor that commonly contributes to poor medication adherence in older adults?

  • Simplified drug regimens (correct)
  • Difficulty opening drug packaging
  • Changes in medication regimen
  • Multiple chronic disorders

Social determinants of health that negatively impact drug adherence include all of the following EXCEPT:

  • Recent discharge from the hospital
  • High literacy (correct)
  • Inability to pay for drugs
  • Living alone

Strategies to improve medication adherence by addressing unintentional non-adherence include all the following EXCEPT:

  • Clear and concise instructions
  • Daily reminders
  • Easy-to-open containers
  • Complex medication schedules (correct)

Which of the following strategies would NOT be typically used to reduce fluctuations between peak and trough drug levels?

<p>Increasing dose size and frequency (D)</p> Signup and view all the answers

What does 'trough' represent in the context of drug responses following repeated doses?

<p>The lowest drug level (C)</p> Signup and view all the answers

A drug classified as a 'diuretic' would fall under which classification?

<p>Pharmacologic classification (D)</p> Signup and view all the answers

Which of the following best exemplifies a drug categorized by its therapeutic classification?

<p>A drug used to lower plasma volume (A)</p> Signup and view all the answers

What distinguishes schedule I drugs from schedule II drugs?

<p>Schedule I drugs have no currently accepted medical use while Schedule II drugs do. (A)</p> Signup and view all the answers

If a medication is classified as a '-statin', it is most likely used for what therapeutic purpose?

<p>Lowering high cholesterol (B)</p> Signup and view all the answers

According to the simple occupancy theory of drug-receptor interaction, what is the primary factor determining the response magnitude?

<p>The number of receptors occupied by the drug. (A)</p> Signup and view all the answers

Approximately what percentage of all doses administered in the US are from over-the-counter drugs?

<p>60% (C)</p> Signup and view all the answers

In the context of modified occupancy theory, how is the potency of a drug related to its affinity for a receptor?

<p>Potency is directly proportional to the affinity. (B)</p> Signup and view all the answers

A drug ending in '-prazole' is most likely used for what therapeutic purpose?

<p>Treatment of peptic ulcer disease (D)</p> Signup and view all the answers

Which of the following best describes an agonist?

<p>A molecule that binds to a receptor and activates it. (B)</p> Signup and view all the answers

Which of the following drug classifications indicates the lowest potential for abuse?

<p>Schedule V (A)</p> Signup and view all the answers

What is the key difference between an agonist and a partial agonist?

<p>Agonists always produce a larger maximal effect than partial agonists. (C)</p> Signup and view all the answers

If a drug is classified as a 'selective serotonin reuptake inhibitor (SSRI)', it falls under which classification?

<p>Pharmacologic classification (D)</p> Signup and view all the answers

How is the maximal efficacy of a drug indicated on a dose-response curve?

<p>By the height of the curve. (C)</p> Signup and view all the answers

What is the primary focus of pharmacologic classification of drugs?

<p>Their chemical structure and mechanism of action (B)</p> Signup and view all the answers

What does the potency of a drug refer to?

<p>How much drug is needed to produce a desired effect. (D)</p> Signup and view all the answers

What does the suffix '-afil' typically indicate in a drug name?

<p>Phosphodiesterase type 5 inhibitor (D)</p> Signup and view all the answers

Why is very high maximal efficacy not always desirable in a drug?

<p>It can lead to increased risk of side effects if not carefully monitored. (A)</p> Signup and view all the answers

If drug A is more potent than drug B, what does this imply about their respective dosages to achieve the same effect?

<p>Drug A requires a lower dosage than drug B. (B)</p> Signup and view all the answers

What are the primary pathogens typically treated in Acute Otitis Media (AOM)?

<p>Haemophilus influenza (C)</p> Signup and view all the answers

Which of the following medications is NOT typically used for analgesia in AOM?

<p>Naproxen (B)</p> Signup and view all the answers

What is necessary for diagnosing AOM?

<p>Acute onset (C)</p> Signup and view all the answers

In cases where the tympanic membrane is ruptured, which treatment option is considered?

<p>Topical antibiotics (A)</p> Signup and view all the answers

What is the correct term for inflammation of the middle ear?

<p>Acute Otitis Media (A)</p> Signup and view all the answers

Which organism is NOT a known cause of fungal otitis externa?

<p>Pseudomonas aeruginosa (B)</p> Signup and view all the answers

What is the recommended observation period for children with AOM before considering antibiotics?

<p>48-72 hours (C)</p> Signup and view all the answers

What are the potential side effects of Glucosamine?

<p>GI disturbances, such as nausea and heartburn (A)</p> Signup and view all the answers

Which of the following populations is considered at risk for necrotizing otitis externa (NOE)?

<p>Diabetics (B)</p> Signup and view all the answers

In which conditions is Ginger root commonly used?

<p>Vertigo and nausea associated with motion sickness (D)</p> Signup and view all the answers

When treating necrotizing otitis externa, which option is part of the standard treatment?

<p>Systemic antibiotics (C)</p> Signup and view all the answers

Which supplement is used to relieve urinary symptoms associated with benign prostatic hyperplasia (BPH)?

<p>Saw Palmetto (A)</p> Signup and view all the answers

What role does the mucociliary system play in the ear?

<p>Transporting bacteria (C)</p> Signup and view all the answers

Which supplement should be avoided in pregnant individuals?

<p>Saw Palmetto (D)</p> Signup and view all the answers

What adverse effect is associated with Kava?

<p>Severe liver damage (A)</p> Signup and view all the answers

Which of the following supplements is known for its antiaging effects?

<p>Resveratrol (A)</p> Signup and view all the answers

What is a common interaction associated with Ginkgo biloba?

<p>Bleeding when taken with antiplatelet and anticoagulant drugs (B)</p> Signup and view all the answers

Which supplement is potentially effective for treating menopausal symptoms?

<p>Soy (C)</p> Signup and view all the answers

At what age is antibacterial therapy recommended for children with AOM regardless of the severity of their illness?

<p>Less than 6 months (D)</p> Signup and view all the answers

Which of the following represents a non-severe illness in a child with AOM?

<p>Mild otalgia and fever below 39°C in the past 24 hours (C)</p> Signup and view all the answers

What is the initial recommended drug for treating antibiotic-resistant otitis media?

<p>Amoxicillin-clavulanate (C)</p> Signup and view all the answers

What is an important prevention method for AOM among children?

<p>Breast-feeding for at least 6 months (B)</p> Signup and view all the answers

For patients with a non-type I penicillin allergy, which antibiotic is recommended?

<p>Ceftriaxone (C)</p> Signup and view all the answers

What dosage of amoxicillin is recommended for children with severe illness?

<p>45 mg/kg twice daily (D)</p> Signup and view all the answers

What is the appropriate response for persistent symptoms after 48-72 hours of observation without antibiotic therapy?

<p>Treat as per immediate antibiotic therapy guidelines (B)</p> Signup and view all the answers

In treating a patient with a type I allergy to penicillin, which antibiotic should be administered?

<p>Clindamycin (B)</p> Signup and view all the answers

Which of the following statements is true regarding children 6 months to 2 years old with AOM and uncertain diagnosis?

<p>Receive antibacterial therapy if illness is severe (B)</p> Signup and view all the answers

Which of the following is a consequence of not addressing tobacco smoke exposure in the prevention of AOM?

<p>Increased likelihood of increased AOM incidence (C)</p> Signup and view all the answers

Flashcards

Pharmacologic Classification

Drugs grouped together by their active ingredient, how they affect the body, and their chemical structure.

Therapeutic Classification

Drugs grouped based on what medical condition they treat, with the focus being on their therapeutic purpose.

Schedule I Drugs

Drugs that have a high potential for abuse and no accepted medical use in the United States.

Schedule II Drugs

Drugs that have a high potential for abuse but are accepted for medical use in the United States, often with restrictions.

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Schedule III Drugs

Drugs that have a lower potential for abuse than Schedule II drugs, with accepted medical use and potential for moderate dependence.

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Schedule IV Drugs

Drugs with a lower risk of abuse than Schedule III drugs, with accepted medical use and potential for limited dependence.

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Schedule V Drugs

Drugs with a lower risk of abuse than Schedule IV drugs, with accepted medical use and minimal potential for dependence.

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Over-the-Counter (OTC) Drugs

Drugs that are available over the counter and do not require a prescription.

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Herbal Remedies

Drugs that are available without a prescription and often used as a supplement or alternative medicine.

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Homeopathic Drugs

Drugs that are manufactured through a process that uses dilutions of a substance, based on the idea of 'like cures like.'

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Efficacy

The degree to which a drug produces the desired effect.

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Potency

The amount of drug needed to produce a desired effect.

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Agonist

A molecule that binds to a receptor and activates it, triggering a response.

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Partial Agonist

A molecule that binds to a receptor but only produces a partial response.

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Antagonist

A molecule that binds to a receptor and blocks its activation.

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Simple Occupancy Theory

The theory that the intensity of a drug's response is directly proportional to the number of receptors occupied.

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Modified Occupancy Theory

The theory that the intensity of a drug's response is based on both the number of receptors occupied and the affinity of the drug for the receptor.

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Dose-Response Relationship

The relationship between the dose of a drug and the intensity of its effect.

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Medication Non-Adherence

When a person doesn't consistently take their medications as prescribed.

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Peak Concentration

Higher levels of a medication in the bloodstream, typically measured just after taking the dose.

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Trough Concentration

Lower levels of a medication in the bloodstream, typically measured just before the next dose.

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Social Determinants of Health

Factors that impact a person's ability to take medication as prescribed, often related to their lifestyle, environment, or finances.

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Promoting Adherence

Strategies to improve medication adherence by simplifying the medication regimen.

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Acute Otitis Media (AOM)

A middle ear infection in young children.

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Garlic as a Supplement

Garlic is a natural supplement, but it needs to be consumed raw to be effective. 2-3 cloves per day is typically recommended.

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Ginger for Nausea

Ginger root can help reduce nausea and vomiting, and may even have anti-inflammatory properties. It's often used for motion sickness, morning sickness, and chemotherapy side effects.

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Observation-based treatment for AOM

Treatment of AOM with antibiotics only if the condition is severe.

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Ginkgo Biloba & Walking

Ginkgo biloba can potentially improve walking distance for people with peripheral arterial disease. However, it can interact with blood-thinning medications, increasing the risk of bleeding.

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Antibiotic therapy for AOM in infants under 6 months

Treatment of AOM with antibiotics regardless of severity in children under 6 months.

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Glucosamine for Osteoarthritis

Glucosamine is commonly used to treat osteoarthritis. However, avoid it if you have a shellfish allergy, and it can cause GI disturbances like nausea and heartburn.

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First-line treatment for AOM

AOM treated with high-dose amoxicillin, a common antibiotic.

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Probiotics & Gut Health

Probiotics are beneficial bacteria and yeast used to treat digestive issues like irritable bowel syndrome, ulcerative colitis, and C. difficile associated diarrhea.

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Antibiotic-resistant AOM

AOM that doesn't respond to standard antibiotics.

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High-dose amoxicillin-clavulanate for AOM

Treatment for antibiotic-resistant AOM.

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Resveratrol as an Antioxidant

Resveratrol is a powerful antioxidant found in grapes, cranberries, and peanuts. It's promoted for its anti-aging effects and protection against chronic diseases.

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Breastfeeding as AOM prevention

Preventing ear infections through breastfeeding for at least 6 months.

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Saw Palmetto & BPH

Saw palmetto is often used to relieve urinary symptoms associated with an enlarged prostate (BPH). However, there's limited scientific evidence to support its effectiveness and it should be avoided during pregnancy.

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Soy for Menopause

Soy can be helpful for menopausal symptoms, but it shouldn't be used with anti-estrogens. It can also increase the risk of oxalate kidney stones.

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Childcare center avoidance for AOM prevention

Avoiding childcare centers during peak respiratory infection season to prevent AOM.

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Vaccination for AOM prevention

Vaccination against influenza and Streptococcus pneumoniae to prevent AOM.

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Alternatives to beta-lactams for AOM

Alternative antibiotics for patients with severe reactions to beta-lactams, like penicillin.

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What is Acute Otitis Externa?

Acute otitis externa (AOE) is an infection of the external auditory canal. The infection can be caused by bacteria, fungi, or viruses. Symptoms include pain, itching, redness, and swelling in the ear canal.

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How are topical medications used to treat AOE?

Treatment for AOE typically involves topical medications, which can be administered in the form of drops or ointments. The specific medication prescribed will depend on the underlying cause of the infection. For bacterial infections, antibiotics are often used. For fungal infections, antifungals are used. For viral infections, antiviral medications are used.

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What happens if the eardrum is ruptured in AOE?

If the tympanic membrane (eardrum) is ruptured, the treatment for AOE may involve oral antibiotics or antifungal medications in addition to topical medications.

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What is Necrotizing Otitis Externa?

Necrotizing otitis externa (NOE) is a serious infection of the external auditory canal that can cause destruction of the bone and cartilage of the ear. NOE is often caused by Pseudomonas aeruginosa and can be life-threatening.

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How is Necrotizing Otitis Externa treated ?

Treatment for NOE often involves intravenous antibiotics, as well as surgery to remove the affected tissue. Sometimes the ear canal needs to be cleaned and the ear needs to be packed.

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What causes fungal otitis externa?

Fungal otitis externa (FOE) is an infection of the external auditory canal caused by fungi. Common fungal causes include Aspergillus, Candida, and Penicillium.

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How do you treat Fungal Otitis Externa?

Treatment for FOE often involves topical antifungal medications. In some cases, oral antifungal medications may be necessary.

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What does the auricle do?

The auricle (pinna) is the visible part of the ear that we see. It collects sound waves and directs them toward the ear canal.

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What is the function of the external auditory canal?

The external auditory canal is a tube that connects the auricle to the tympanic membrane (eardrum). It is lined with skin and produces wax that helps to protect the ear from foreign objects and infection.

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What is the function of the Middle Ear?

The middle ear is located behind the tympanic membrane. It is an air-filled space that contains three tiny bones called ossicles. The ossicles transmit sound vibrations from the tympanic membrane to the inner ear.

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Study Notes

Pharmacology: The Basics

  • A drug is any chemical that affects living processes.
  • Pharmacology is the study of drugs and their interactions with living systems.
  • Clinical Pharmacology focuses on the use of drugs in humans.
  • Therapeutics (Pharmacotherapeutics) describes the use of drugs to treat, prevent or diagnose diseases or conditions.

Pharmacology: The Therapeutic Objective

  • The aim of drug therapy is to provide maximum benefit with minimal harm.
  • Essential components for successful drug therapy include knowledge, skill, and good judgment.
  • The objective is to achieve greater good than harm when using drugs.

Properties of an Ideal Drug: The Big 3

  • Effectiveness is the most important characteristic for a drug.
  • Safety is also critical and paramount.
  • Selectivity is essential to minimize the side effects of the drug.

The Ideal Drug: Other Properties

  • Drugs should have a rapid and reversible effect.
  • Drugs should have a predictable outcome and effect.
  • Ease of administration is a key factor.
  • Drugs should not interact with each other.
  • Cost should be low.
  • Chemical stability is a must.
  • Generic names should be simple to memorize and use.

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