Pharmacology 1: Eicosanoids in Thrombosis and Asthma
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Questions and Answers

Which of the following eicosanoids has a cytoprotective effect on the gastric mucosa?

  • PGE1
  • TXA2
  • PGs (correct)
  • PGI2

    • In the renal system, which of the following eicosanoids increases glomerular filtration rate?

  • TXA2
  • PGE1, PGE2, PG12 (correct)
  • PGE2, PGE4, PGD4
  • Leukotriene C4

    • Which of the following eicosanoids is a secondary mediator of bronchoconstriction in asthma?

  • PGF2
  • Leukotriene E4
  • PGE2, TXA2
  • TXA2 , PGF2 (correct)

    • Which of the following eicosanoids is used to maintain the ductus arteriosus patent in some neonates awaiting cardiac surgery?

    <p>Bimaprost (PGF2a)</p> Signup and view all the answers

    Which of the following eicosanoids promotes platelet aggregation?

    <p>TXA2</p> Signup and view all the answers

    Which of the following eicosanoids is a powerful bronchodilator and is given to asthmatic persons in the form of aerosol?

    <p>PGE2</p> Signup and view all the answers

    What is the outcome of a wrong ratio of prostaglandins in seminal fluid?

    <p>Infertility in men</p> Signup and view all the answers

    What is the effect of large doses of Aspirin on seminal plasma?

    <p>Decrease in prostaglandin content</p> Signup and view all the answers

    What is the role of LTB4 in inflammatory bowel disease?

    <p>Increases inflammation</p> Signup and view all the answers

    What is the effect of LTC4 and LTD4 on the airways?

    <p>Constrict smooth muscle</p> Signup and view all the answers

    What is the effect of PGE2 and PGF2α on labour?

    <p>Initiate and stimulate labour</p> Signup and view all the answers

    What is the role of prostaglandins in menstruation?

    <p>Increase in prostaglandin synthesis</p> Signup and view all the answers

    Which receptor is involved in the contraction of pregnant uterus and GIT smooth muscles?

    <p>EP3</p> Signup and view all the answers

    Which prostaglandin causes vasodilatation and inhibits platelet aggregation?

    <p>PGE2, EP3</p> Signup and view all the answers

    What is the main effect of TXA2 on blood vessels?

    <p>Vasoconstriction</p> Signup and view all the answers

    Which of the following is responsible for the inhibition of gastric acid secretion?

    <p>PGE2 on EP3 receptors</p> Signup and view all the answers

    What is the effect of PGI2 on platelets?

    <p>Inhibition of aggregation</p> Signup and view all the answers

    Which receptor is involved in the relaxation of bronchial smooth muscles?

    <p>EP2</p> Signup and view all the answers

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