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Pharmacology 1: Eicosanoids in Thrombosis and Asthma

18 Questions

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Pharmacology 1: Eicosanoids in Thrombosis and Asthma

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Questions and Answers

Which of the following eicosanoids has a cytoprotective effect on the gastric mucosa?

PGE1

TXA2

PGs (correct)

PGI2

In the renal system, which of the following eicosanoids increases glomerular filtration rate?

TXA2

PGE1, PGE2, PG12 (correct)

PGE2, PGE4, PGD4

Leukotriene C4

Which of the following eicosanoids is a secondary mediator of bronchoconstriction in asthma?

PGF2

Leukotriene E4

PGE2, TXA2

TXA2 , PGF2 (correct)

Which of the following eicosanoids is used to maintain the ductus arteriosus patent in some neonates awaiting cardiac surgery?

Bimaprost (PGF2a) (C) Signup and view all the answers

Which of the following eicosanoids promotes platelet aggregation?

TXA2 (D) Signup and view all the answers

Which of the following eicosanoids is a powerful bronchodilator and is given to asthmatic persons in the form of aerosol?

PGE2 (A) Signup and view all the answers

What is the outcome of a wrong ratio of prostaglandins in seminal fluid?

Infertility in men (B) Signup and view all the answers

What is the effect of large doses of Aspirin on seminal plasma?

Decrease in prostaglandin content (A) Signup and view all the answers

What is the role of LTB4 in inflammatory bowel disease?

Increases inflammation (B) Signup and view all the answers

What is the effect of LTC4 and LTD4 on the airways?

Constrict smooth muscle (A) Signup and view all the answers

What is the effect of PGE2 and PGF2α on labour?

Initiate and stimulate labour (D) Signup and view all the answers

What is the role of prostaglandins in menstruation?

Increase in prostaglandin synthesis (D) Signup and view all the answers

Which receptor is involved in the contraction of pregnant uterus and GIT smooth muscles?

EP3 (A) Signup and view all the answers

Which prostaglandin causes vasodilatation and inhibits platelet aggregation?

PGE2, EP3 (C) Signup and view all the answers

What is the main effect of TXA2 on blood vessels?

Vasoconstriction (D) Signup and view all the answers