Podcast
Questions and Answers
Which pathway is responsible for motor disturbances such as acute dystonia and tardive dyskinesia caused by antipsychotic drugs?
Which pathway is responsible for motor disturbances such as acute dystonia and tardive dyskinesia caused by antipsychotic drugs?
- Tuberohypophyseal pathway
- Mesocortical pathway
- Mesolimbic pathway
- Nigrostriatal pathway (correct)
Which of the following is NOT a side effect of blocking the tuberohypophyseal pathway by antipsychotic drugs?
Which of the following is NOT a side effect of blocking the tuberohypophyseal pathway by antipsychotic drugs?
- Lactation in both men and women
- Breast swelling and pain
- Increase in plasma prolactin concentration
- Parkinsonian-like syndrome (correct)
Which receptor type is responsible for inhibiting prolactin secretion, and is blocked by antipsychotic drugs leading to an increase in plasma prolactin concentration?
Which receptor type is responsible for inhibiting prolactin secretion, and is blocked by antipsychotic drugs leading to an increase in plasma prolactin concentration?
- Dopamine D2 receptor (correct)
- Cholinergic muscarinic receptor
- Histamine receptor
- α-adrenoceptor
Which type of antipsychotic drugs is more selective for dopamine D2 receptor and has a receptor profile as a basis for its distinction?
Which type of antipsychotic drugs is more selective for dopamine D2 receptor and has a receptor profile as a basis for its distinction?
Which side effect is less frequent with the newer 'atypical' antipsychotics compared to the classical 'typical' antipsychotics?
Which side effect is less frequent with the newer 'atypical' antipsychotics compared to the classical 'typical' antipsychotics?
Which pathway, when blocked by antipsychotic drugs, leads to an increase in plasma prolactin concentration?
Which pathway, when blocked by antipsychotic drugs, leads to an increase in plasma prolactin concentration?
Which receptor type, when blocked by antipsychotic drugs, causes sedation due to H1 block and anticholinergic effects due to muscarinic block?
Which receptor type, when blocked by antipsychotic drugs, causes sedation due to H1 block and anticholinergic effects due to muscarinic block?
Which syndrome, characterized by muscle rigidity, fever, autonomic instability, and delirium, can be caused by neuroleptics at normal clinical doses?
Which syndrome, characterized by muscle rigidity, fever, autonomic instability, and delirium, can be caused by neuroleptics at normal clinical doses?
Which enzyme is involved in the degradation of dopamine?
Which enzyme is involved in the degradation of dopamine?
Which receptor type exerts its effects mainly via Gs protein?
Which receptor type exerts its effects mainly via Gs protein?
Which pathway is primarily associated with the control of voluntary movement?
Which pathway is primarily associated with the control of voluntary movement?
Which disorder is primarily associated with the hyperactivity of the mesolimbocortical dopaminergic pathway?
Which disorder is primarily associated with the hyperactivity of the mesolimbocortical dopaminergic pathway?
Which neurotransmitter is primarily inhibited by dopamine in the tuberohypophyseal pathway?
Which neurotransmitter is primarily inhibited by dopamine in the tuberohypophyseal pathway?
Which protein is associated with the formation of Lewy bodies in Parkinson's disease?
Which protein is associated with the formation of Lewy bodies in Parkinson's disease?
Which drug is the most effective treatment for Parkinson's disease in terms of dopamine replacement?
Which drug is the most effective treatment for Parkinson's disease in terms of dopamine replacement?
Which type of drug is used to inhibit dopamine metabolism in the treatment of Parkinson's disease?
Which type of drug is used to inhibit dopamine metabolism in the treatment of Parkinson's disease?
Which receptor type opposes the effects of dopamine in the striatum?
Which receptor type opposes the effects of dopamine in the striatum?
Which pathway is primarily associated with the mediation of rewarding stimuli?
Which pathway is primarily associated with the mediation of rewarding stimuli?
Which dopaminergic pathway is primarily affected in Parkinson's disease?
Which dopaminergic pathway is primarily affected in Parkinson's disease?
Which enzyme is responsible for the conversion of L-DOPA to dopamine?
Which enzyme is responsible for the conversion of L-DOPA to dopamine?
What percentage of patients respond positively to levodopa treatment for Parkinson's disease?
What percentage of patients respond positively to levodopa treatment for Parkinson's disease?
Which neurotransmitter system is thought to be overactive in the dopamine hypothesis of schizophrenia?
Which neurotransmitter system is thought to be overactive in the dopamine hypothesis of schizophrenia?
What is the main side effect of levodopa treatment for Parkinson's disease?
What is the main side effect of levodopa treatment for Parkinson's disease?
What is the clinical efficacy of antipsychotic drugs strongly correlated with?
What is the clinical efficacy of antipsychotic drugs strongly correlated with?
Which drug is converted to dopamine only in the brain, reducing peripheral side effects?
Which drug is converted to dopamine only in the brain, reducing peripheral side effects?
What percentage of the population is affected by schizophrenia?
What percentage of the population is affected by schizophrenia?
Which type of drugs act as antagonists at dopamine D2 receptors in the treatment of schizophrenia?
Which type of drugs act as antagonists at dopamine D2 receptors in the treatment of schizophrenia?
What is the main side effect profile contributor of antipsychotic drugs?
What is the main side effect profile contributor of antipsychotic drugs?
What is the estimated percentage block of D2 receptors required for antipsychotic effects?
What is the estimated percentage block of D2 receptors required for antipsychotic effects?
Which neurotransmitter system do antipsychotic drugs primarily act on?
Which neurotransmitter system do antipsychotic drugs primarily act on?
How many different drugs are in clinical use as antipsychotic drugs, neuroleptic drugs, and major tranquilizers?
How many different drugs are in clinical use as antipsychotic drugs, neuroleptic drugs, and major tranquilizers?
How long does it take for chronic effects of antipsychotic drugs to develop?
How long does it take for chronic effects of antipsychotic drugs to develop?
Degeneration of which area in the brain is associated with the motor effects seen in Parkinson's disease?
Degeneration of which area in the brain is associated with the motor effects seen in Parkinson's disease?
Which enzyme is responsible for the conversion of tyrosine to dopamine?
Which enzyme is responsible for the conversion of tyrosine to dopamine?
What is the role of dopamine in the tuberohypophyseal system?
What is the role of dopamine in the tuberohypophyseal system?
How is dopamine terminated within the synaptic cleft?
How is dopamine terminated within the synaptic cleft?
Study Notes
Pharmacological Treatments for Parkinson's Disease and Schizophrenia
- Levodopa is converted to dopamine only in the brain, reducing peripheral side effects
- About 80% of patients respond positively to levodopa, with ~20% restored to normal motor function
- Main side effects of levodopa treatment include dyskinesias and on-off effects
- Other drug treatments for Parkinson's disease include MAO-B inhibitors, COMT inhibitors, dopamine receptor agonists, muscarinic cholinergic antagonists, and NMDA receptor antagonists
- Schizophrenia affects ~1% of the population and is thought to be a neurodevelopmental disorder
- The disease can manifest in early adulthood and can be relapsing & remitting or chronic and progressive
- The dopamine hypothesis of schizophrenia states that overactivity in the dopaminergic system leads to the disease
- All anti-schizophrenic drugs act as antagonists at dopamine D2 receptors
- Antipsychotic drugs may also affect other neurotransmitter systems, contributing to their side effect profile
- Clinical efficacy of antipsychotic drugs strongly correlates with affinity for the D2 receptor
- Antipsychotic effects require ~80% block of D2 receptors, while chronic effects take weeks to develop
- More than 40 different drugs are in clinical use as antipsychotic drugs, neuroleptic drugs, and major tranquilizers.
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Description
Test your knowledge of pharmacological treatments for Parkinson's disease and schizophrenia with this quiz. Explore the mechanisms of action and side effects of drugs such as levodopa, MAO-B inhibitors, COMT inhibitors, dopamine receptor agonists, and antipsychotic drugs. Dive into the dopamine hypothesis of schizophrenia and learn about the neurotransmitter systems affected by antipsychotic drugs.
