Pharmacological Thromboprophylaxis Quiz
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Questions and Answers

What is a benefit of using LMWH over unfractionated heparin?

  • Reduced risk of renal failure
  • Lower cost
  • More predictable pharmacokinetics (correct)
  • Longer half-life

    • Why is dose adjustment required for LMWH in patients with renal failure?

  • It is excreted by the kidneys (correct)
  • It is less effective in renal failure
  • It increases the risk of VTHUYTRE
  • It has a longer half-life

    • What did a systematic review and meta-analysis find about preoperative pharmacoprophylaxis and VTE incidence?

  • Increased risk of VTE
  • Unpredictable effects on VTE
  • No significant impact on VTE incidence
  • 40% reduction in the odds of VTE (correct)

    • What complication is LMWH specifically noted to have reduced compared to unfractionated heparin?

    <p>Heparin-induced thrombocytopaenia (HIT)</p> Signup and view all the answers

    Why is LMWH the preferred agent of choice in many countries, including the UK?

    <p>More cost-effective than unfractionated heparin</p> Signup and view all the answers

    What is a reason for low-molecular-weight heparin (LMWH) being the preferred agent of choice in many countries, including the UK?

    <p>More predictable pharmacokinetics and reduced complications like heparin-induced thrombocytopaenia (HIT)</p> Signup and view all the answers

    What did a systematic review and meta-analysis find about the efficacy of preoperative pharmacoprophylaxis (unfractionated heparin and/or LMWH) on the incidence of VTE following major gynaecologic and gynaecology oncological procedures?

    <p>40% reduction in the odds of VTE when preoperative pharmacoprophylaxis is given versus no preoperative pharmacoprophylaxi</p> Signup and view all the answers

    Why does low-molecular-weight heparin (LMWH) require dose adjustment in patients with renal failure?

    <p>It is excreted by the kidneys and has a long half-life</p> Signup and view all the answers

    What did a systematic review and meta-analysis find about the efficacy of low-molecular-weight heparin (LMWH) compared to unfractionated heparin in the reduction of VTE?

    <p>LMWH was shown to be as effective as unfractionated heparin in the reduction of VTE</p> Signup and view all the answers

    What is a benefit of using low-molecular-weight heparin (LMWH) over unfractionated heparin?

    <p>More cost-effective and once-daily dosing</p> Signup and view all the answers

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