Pharmacological Thromboprophylaxis Quiz

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Questions and Answers

What is a benefit of using LMWH over unfractionated heparin?

  • Reduced risk of renal failure
  • Lower cost
  • More predictable pharmacokinetics (correct)
  • Longer half-life

Why is dose adjustment required for LMWH in patients with renal failure?

  • It is excreted by the kidneys (correct)
  • It is less effective in renal failure
  • It increases the risk of VTHUYTRE
  • It has a longer half-life

What did a systematic review and meta-analysis find about preoperative pharmacoprophylaxis and VTE incidence?

  • Increased risk of VTE
  • Unpredictable effects on VTE
  • No significant impact on VTE incidence
  • 40% reduction in the odds of VTE (correct)

What complication is LMWH specifically noted to have reduced compared to unfractionated heparin?

<p>Heparin-induced thrombocytopaenia (HIT) (C)</p> Signup and view all the answers

Why is LMWH the preferred agent of choice in many countries, including the UK?

<p>More cost-effective than unfractionated heparin (C)</p> Signup and view all the answers

What is a reason for low-molecular-weight heparin (LMWH) being the preferred agent of choice in many countries, including the UK?

<p>More predictable pharmacokinetics and reduced complications like heparin-induced thrombocytopaenia (HIT) (D)</p> Signup and view all the answers

What did a systematic review and meta-analysis find about the efficacy of preoperative pharmacoprophylaxis (unfractionated heparin and/or LMWH) on the incidence of VTE following major gynaecologic and gynaecology oncological procedures?

<p>40% reduction in the odds of VTE when preoperative pharmacoprophylaxis is given versus no preoperative pharmacoprophylaxi (C)</p> Signup and view all the answers

Why does low-molecular-weight heparin (LMWH) require dose adjustment in patients with renal failure?

<p>It is excreted by the kidneys and has a long half-life (D)</p> Signup and view all the answers

What did a systematic review and meta-analysis find about the efficacy of low-molecular-weight heparin (LMWH) compared to unfractionated heparin in the reduction of VTE?

<p>LMWH was shown to be as effective as unfractionated heparin in the reduction of VTE (C)</p> Signup and view all the answers

What is a benefit of using low-molecular-weight heparin (LMWH) over unfractionated heparin?

<p>More cost-effective and once-daily dosing (B)</p> Signup and view all the answers

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