5 Questions
Typically, when a molecular target has been selected, and lead compounds have been identified which act on it selectively, and which _______ ‘drug-like’ chemical attributes (including suitable pharmacokinetic properties), the next stage is a detailed pharmacological evaluation.
are judged to have
‘Investigation of the effects’ to determine which, if any, is the most suitable for further development (i.e. for nomination as a drug candidate) ________ small number of compounds.
requires
‘Investigation of the effects’ to determine which, if any, is the most suitable for further development (i.e. for nomination as a drug candidate) involves testing in a _______ of test systems (i.e., whole animals).
range
The types of pharmacological evaluations include __________ screening - in vitro tests on a broad range of possible drug targets to determine whether the compound.
selectivity
The types of pharmacological evaluations include selectivity screening - in vitro tests on a broad range of possible drug targets to determine whether the ________ has an effect.
compound
This quiz covers the characteristics of pharmacological test systems in drug discovery. Test your knowledge on selecting molecular targets, identifying lead compounds, and evaluating their chemical attributes.
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