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Typically, when a molecular target has been selected, and lead compounds have been identified which act on it selectively, and which _______ ‘drug-like’ chemical attributes (including suitable pharmacokinetic properties), the next stage is a detailed pharmacological evaluation.
Typically, when a molecular target has been selected, and lead compounds have been identified which act on it selectively, and which _______ ‘drug-like’ chemical attributes (including suitable pharmacokinetic properties), the next stage is a detailed pharmacological evaluation.
are judged to have
‘Investigation of the effects’ to determine which, if any, is the most suitable for further development (i.e. for nomination as a drug candidate) ________ small number of compounds.
‘Investigation of the effects’ to determine which, if any, is the most suitable for further development (i.e. for nomination as a drug candidate) ________ small number of compounds.
requires
‘Investigation of the effects’ to determine which, if any, is the most suitable for further development (i.e. for nomination as a drug candidate) involves testing in a _______ of test systems (i.e., whole animals).
‘Investigation of the effects’ to determine which, if any, is the most suitable for further development (i.e. for nomination as a drug candidate) involves testing in a _______ of test systems (i.e., whole animals).
range
The types of pharmacological evaluations include __________ screening - in vitro tests on a broad range of possible drug targets to determine whether the compound.
The types of pharmacological evaluations include __________ screening - in vitro tests on a broad range of possible drug targets to determine whether the compound.
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The types of pharmacological evaluations include selectivity screening - in vitro tests on a broad range of possible drug targets to determine whether the ________ has an effect.
The types of pharmacological evaluations include selectivity screening - in vitro tests on a broad range of possible drug targets to determine whether the ________ has an effect.
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