Pharmacological Interactions with Levodopa
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Questions and Answers

What is the primary function of specific cells in the Substantia Nigra?

  • Regulating movement through serotonin secretion
  • Maintaining cognitive function through acetylcholine release
  • Producing dopamine as a neurotransmitter (correct)
  • Modulating emotional responses through norepinephrine release

In the context of C Ischemia, what is the significance of the Substantia Nigra?

  • It is primarily involved in the regulation of auditory responses
  • It plays a crucial role in the production and secretion of dopamine (correct)
  • It is responsible for regulating blood flow to the brain
  • It is involved in the processing of visual information

What is the primary neurotransmitter affected in C Ischemia?

  • Norepinephrine
  • Dopamine (correct)
  • Serotonin
  • Acetylcholine

What is the primary function of dopamine in the brain?

<p>Playing a role in motor control and reward processing (C)</p> Signup and view all the answers

What is the effect of C Ischemia on the cells in the Substantia Nigra?

<p>Decreased production and secretion of dopamine (C)</p> Signup and view all the answers

Which type of transport system is responsible for carrying levodopa into the brain?

<p>Amino acid transport systems (A)</p> Signup and view all the answers

What is the enzyme responsible for converting levodopa into dopamine in the brain?

<p>L-aromatic amino acid decarboxylase (C)</p> Signup and view all the answers

What is the primary reason why levodopa is transported into the brain?

<p>To produce dopamine (A)</p> Signup and view all the answers

What is a characteristic of a patient suffering from CoarseResting tumors?

<p>Shuffling gait (B)</p> Signup and view all the answers

What is the class of molecule that levodopa belongs to?

<p>Amino acid (A)</p> Signup and view all the answers

Why is Levodopa ineffective as a treatment for CoarseResting tumors when administered alone?

<p>It cannot cross the blood-brain barrier (C)</p> Signup and view all the answers

In which compartment of the brain is levodopa converted into dopamine?

<p>The brain itself (A)</p> Signup and view all the answers

What is a common cause of death in patients with CoarseResting tumors?

<p>Chest infection (C)</p> Signup and view all the answers

Why does Dopamine not work as a replacement therapy for CoarseResting tumors?

<p>It cannot cross the blood-brain barrier (C)</p> Signup and view all the answers

What is a characteristic of Brodykinesia?

<p>Slow and labored movements (B)</p> Signup and view all the answers

What is the consequence of blocking the breakdown of tyramine?

<p>Hypertensive crisis (C)</p> Signup and view all the answers

Why is it important to avoid consuming cheese with certain medications?

<p>To avoid adverse interactions with the MAO enzyme (C)</p> Signup and view all the answers

Which of the following drugs will decrease the efficacy of levodopa?

<p>Pyridoxine (A)</p> Signup and view all the answers

What is the role of the MAO enzyme in the body?

<p>To break down tyramine (A)</p> Signup and view all the answers

What is the primary reason to avoid giving non-selective MAO inhibitors with levodopa?

<p>Risk of hypertensive crisis (B)</p> Signup and view all the answers

Which type of MAO inhibitor acts on dopamine, norepinephrine, and epinephrine?

<p>MAO-A (A)</p> Signup and view all the answers

What is the potential result of combining certain medications with foods high in tyramine?

<p>Hypertensive crisis (A)</p> Signup and view all the answers

What is the underlying mechanism of the interaction between certain medications and tyramine?

<p>Inhibition of the MAO enzyme (C)</p> Signup and view all the answers

What is the benefit of using selective MAO-B inhibitors like selegiline or rasagiline with levodopa?

<p>They reduce the risk of hypertensive crisis (D)</p> Signup and view all the answers

Why can metoclopramide be a problem when given with levodopa?

<p>It can cross the blood-brain barrier and block dopamine receptors (D)</p> Signup and view all the answers

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