30 Questions
Which of the following statements about oxybutynin is correct?
Oxybutynin is contraindicated in patients with cardiovascular instability.
What is the onset of action of transdermal oxybutynin?
24 to 48 hours
What is the duration of action of transdermal oxybutynin?
96 hours
What is the main mechanism of action of oxybutynin?
Relaxation of smooth muscle
What is the recommended maximum dosage of oxybutynin for older adults?
2.5 mg PO two to three times per day
What are the most commonly reported CNS adverse effects of oxybutynin?
Drowsiness, dizziness, and blurred vision
What are the contraindications to oxybutynin?
All of the above
What is the potential interaction between oxybutynin and phenothiazines?
Increased anticholinergic effects
What is the main therapeutic effect of darifenacin?
Decreased urinary incontinence
What is the metabolism of darifenacin primarily dependent on?
CYP3A4 and CYP2D6 enzymes
Which type of medication is considered first-line for urge incontinence?
Anticholinergic agents
What medication should be used with caution in patients with hypertension due to its potential to increase blood pressure?
Beta-3 adrenergic agonists
Which medication can decrease bladder contractions as well as increase bladder neck resistance?
Tricyclic antidepressants
Which medication may be used to treat stress incontinence but needs to be used with caution in men with prostatic hyperplasia and in patients with hypertension?
Alpha-adrenergic receptor agonists
Which class of drugs is considered the drug of choice for their antispasmodic effects on smooth muscle to relieve the symptoms of urinary incontinence and frequency that accompany an overactive bladder?
Anticholinergic drugs
Which medication is the prototype urinary antispasmodic that is available in oral and transdermal forms?
Oxybutynin
What is the onset of action of the oral preparation of oxybutynin?
30 to 60 minutes
What is the peak of the oral preparation of oxybutynin?
3 to 6 hours
What is the duration of the oral preparation of oxybutynin?
6 to 10 hours
What type of interventions does pharmacologic therapy work best when used as an adjunct to?
Behavioral interventions
Which drug is indicated for the treatment of overactive bladder with symptoms of urgency, urge incontinence, and frequency?
Solifenacin (Vesicare)
Which drug is more selective for muscarinic receptors in the urinary bladder than in other areas of the body, such as the salivary glands?
Tolterodine (Detrol, Detrol LA)
Which drug reduces the tone of smooth muscle in the bladder, exerting an antispasmodic effect?
Trospium chloride
Which drug is well absorbed after oral administration, 98% bound to plasma proteins, and extensively metabolized in the liver by CYP3A4 enzymes?
Solifenacin (Vesicare)
Which drug should be taken at least 1 hour before meals or on an empty stomach due to its absorption characteristics?
Trospium chloride
Which drug is recommended to have reduced dosages for patients with moderate renal or hepatic impairment?
Solifenacin (Vesicare)
Which drug has the potential for interaction with other drugs that are eliminated by active tubular secretion, resulting in increased serum concentration of either the drug or the coadministered drug?
Trospium chloride
Which drug is not recommended for patients with severe hepatic impairment?
Solifenacin (Vesicare)
Which drug is available in an extended-release form?
Tolterodine (Detrol, Detrol LA)
Which drug may prolong QT intervals, especially at higher dosages, potentially resulting in dysrhythmias?
Solifenacin (Vesicare)
Test your knowledge on pharmacologic therapy for urinary incontinence. Learn about the different types of medications used, their effectiveness, and their role in conjunction with behavioral interventions.
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