Pharmacokinetics of Nicotine - DIMT BS PHARM-401
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Questions and Answers

What is the primary mechanism of action of nicotine at low doses?

  • Ganglionic stimulation by depolarization (correct)
  • Central nervous system depression
  • Parasympathetic ganglia inhibition
  • Ganglionic blockade

    • What is a therapeutic effect of nicotine on the central nervous system?

  • Increased appetite
  • Improved attention and learning (correct)
  • Cardiovascular disease
  • Respiratory paralysis

    • What is a potential adverse effect of high doses of nicotine?

  • Cardiovascular disease
  • Respiratory paralysis and severe hypotension (correct)
  • Appetite stimulation
  • Central nervous system stimulation

    • What is an effect of nicotine on the peripheral nervous system?

    <p>Stimulation of parasympathetic ganglia</p> Signup and view all the answers

    What is a potential risk factor associated with nicotine use?

    <p>Lung and cardiovascular disease</p> Signup and view all the answers

    What is the effect of nicotine on appetite?

    <p>Appetite suppression</p> Signup and view all the answers

    Which of the following mechanisms of action is NOT associated with methylxanthines?

    <p>Translocation of extracellular potassium</p> Signup and view all the answers

    What is the effect of caffeine on the cardiovascular system at high doses?

    <p>Positive inotropic and chronotropic effects</p> Signup and view all the answers

    How do methylxanthines distribute in the body?

    <p>They are distributed throughout the body, including the brain</p> Signup and view all the answers

    What is a common adverse effect of methylxanthines at low doses?

    <p>Insomnia</p> Signup and view all the answers

    What is the primary pathway for the metabolism of methylxanthines in the liver?

    <p>CYPIA2 pathway</p> Signup and view all the answers

    What is the effect of caffeine on mental alertness at a dose of 100-200mg?

    <p>Decrease in fatigue and increased mental alertness</p> Signup and view all the answers

    What is the primary mechanism of action of cocaine?

    <p>Blockade of the reuptake of the monoamines into the presynaptic terminals</p> Signup and view all the answers

    What is the effect of nicotine on the gastrointestinal tract at higher doses?

    <p>Cessation of activity due to blockage of parasympathetic ganglia</p> Signup and view all the answers

    How is nicotine absorbed into the body?

    <p>Due to its high lipid solubility</p> Signup and view all the answers

    What is a common side effect of nicotine intake?

    <p>Increased heart rate and blood pressure</p> Signup and view all the answers

    What is the effect of chronic cocaine intake on dopamine levels?

    <p>Depletion of dopamine</p> Signup and view all the answers

    What is a significant consequence of cigarette smoking on drug metabolism?

    <p>Increased metabolism of certain drugs</p> Signup and view all the answers

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