Pharmacokinetics of General Anesthetics
20 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the end point of an anesthetic act?

  • Wakefulness
  • Sleep (correct)
  • Consciousness
  • Drowsiness
  • In the two-compartment model of general anesthetics, what does the central compartment represent?

  • The CNS
  • The biophase (correct)
  • The rest of the body
  • The effect compartment
  • Why is a two-compartment model used despite not knowing rate constants for most general anesthetics?

  • Difficulties in CNS drug concentration examination in humans (correct)
  • Due to CNS concentration being easily measurable in humans
  • Because of high molecular weight of general anesthetics
  • High metabolism rate of general anesthetics
  • How do general anesthetics often leave the body?

    <p>Via metabolism and excretion pathways</p> Signup and view all the answers

    What characteristic makes it challenging to determine rate constants for most general anesthetics?

    <p>High CNS concentration</p> Signup and view all the answers

    Which compartment in the two-compartment model represents the rest of the body?

    <p>Second compartment</p> Signup and view all the answers

    Which type of drug elimination is primarily affected by a reduction in blood flow to the liver or liver disease?

    <p>Flow-limited elimination</p> Signup and view all the answers

    In which metabolism phase are drugs usually chemically altered in the liver and/or conjugated with glucuronic acid or sulphate for 'capacity-limited' elimination?

    <p>Phase 2</p> Signup and view all the answers

    What type of circulation does high lipid solubility favor, contributing to a prolonged duration of action of drugs?

    <p>Enterohepatic circulation</p> Signup and view all the answers

    Which factor can cause delayed recovery from anesthesia in the post-operative period related to volatile agents or their metabolites?

    <p>Potential toxicity of active metabolites</p> Signup and view all the answers

    What distinguishes drugs exhibiting 'flow-limited' elimination from those exhibiting 'capacity-limited' elimination?

    <p>Passing through the liver in one transit</p> Signup and view all the answers

    Which factor influences the absorption of an inhaled anesthetic the most?

    <p>Partial pressure in the alveoli</p> Signup and view all the answers

    What contributes to the rapid distribution of anesthesia to the brain, heart, kidney, and liver?

    <p>High perfusion of tissues</p> Signup and view all the answers

    Which organ is mentioned as being less perfused and therefore having less anesthetic during distribution?

    <p>Muscle</p> Signup and view all the answers

    What process terminates CNS effects by moving the drug from the site of action to other tissues?

    <p>Redistribution</p> Signup and view all the answers

    Which type of metabolism can produce toxic metabolites among inhaled anesthetics?

    <p>Oxidative metabolism</p> Signup and view all the answers

    Which intravenous anesthetic is processed through hydrolysis of the imidazole double bond for subsequent metabolism to inactive metabolites?

    <p>Etomidate</p> Signup and view all the answers

    Which general anesthetic can result in hepatotoxicity due to oxidative metabolism by the hepatic p450 enzyme system?

    <p>Halothane</p> Signup and view all the answers

    Which organ system plays a crucial role in facilitating fast drug recovery by conjugating intravenous anesthetics to inactive water-soluble metabolites?

    <p>Renal system</p> Signup and view all the answers

    Which aspect of general anesthetics facilitates their elimination through the lungs?

    <p>Volatile nature</p> Signup and view all the answers

    More Like This

    General Pharmacology Lec 1
    11 questions
    General Pharmacology Quiz
    10 questions
    Farmacología General y Farmacocinética
    16 questions
    Use Quizgecko on...
    Browser
    Browser