57 Questions
Which of the following statements about sedatives is correct?
Sedatives induce a state of calm or sleep.
What is the chemical structure of propofol?
2,6-diisopropyl phenol
What is the mechanism of action of propofol?
Selective modulator of GABAA receptors.
Which drug is associated with a significant decrease in intraocular pressure?
Propofol
Which drug does not alter tests of coagulation or platelet function?
Thiopental
Which drug has been observed to cause anaphylaxis on first exposure, especially in patients with a history of other allergies?
Propofol
Which drug is a selective modulator of GABAA receptors?
Etomidate
Which of the following statements about diazepam is true?
Diazepam is metabolized by hepatic microsomal enzymes.
What is the recommended timeframe for administering diazepam before surgery?
20 minutes
What is the protein binding characteristic of diazepam?
High degree of protein binding
Which of the following is a characteristic of benzodiazepines?
High lipid solubility
Which of the following is a side effect of chronic administration of benzodiazepines?
Fatigue and drowsiness
Which of the following drugs exert synergistic sedative effects with benzodiazepines?
Opioids
Which of the following is true about the pharmacokinetics of midazolam?
Metabolized by CYP3A4
Which of the following is true about propofol pharmacokinetics?
Propofol is primarily eliminated through the lungs
Which population requires a lower induction dose of propofol?
Elderly
What is the typical concentration of propofol in the blood for conscious sedation?
2 to 6 µg/mL
What is the effect of propofol on cerebral blood flow?
Decreases cerebral blood flow
Which of the following is a characteristic of etomidate metabolism?
Rapidly metabolized by hydrolysis of the ethyl ester side chain to its carboxylic acid ester
Which of the following is a side effect of etomidate on the cardiovascular system?
Minimal changes in heart rate, stroke volume, and cardiac output
Which of the following is a characteristic of etomidate's effect on ventilation?
Depressant effects on ventilation are less than barbiturates and propofol
Which of the following is a principal pharmacologic effect of benzodiazepines?
Anxiolysis, sedation, anticonvulsant, and spinal cord-mediated skeletal muscle relaxation
Which of the following drugs is a prodrug that has a risk of infection, pain on injection, hypertriglyceridemia, and pulmonary embolism?
Fospropofol
What is the chemical structure of propofol?
2,6-diisopropyl phenol
Which of the following drugs is a low-lipid emulsion that does not require a preservative but has a higher pain on injection?
Ampofol
Which of the following is true about the elimination half-time of diazepam in healthy volunteers?
It ranges from 21 to 37 hours.
What is the protein binding characteristic of diazepam?
It has a high degree of protein binding.
What is the recommended timeframe for administering diazepam before surgery?
20 minutes before surgery
Which of the following drugs is associated with a high incidence of pain on injection?
Propofol
Which drug is chemically unrelated to any other drug used for IV induction?
Etomidate
Which drug has been observed to cause bradycardia and asystole in healthy adult patients, even with anticholinergic prophylaxis?
Thiopental
Which drug is a potent antioxidant and has neuroprotective effects related to its antioxidant properties?
Propofol
Which of the following factors contributes to the differences in onset and duration among benzodiazepines?
Pharmacokinetics (uptake, distribution, metabolism and elimination)
Which of the following drugs exerts synergistic sedative effects with benzodiazepines?
All of the above
Which of the following is a side effect of chronic administration of benzodiazepines?
All of the above
Which of the following drugs has a water-soluble form that is stable in aqueous solution and rapidly metabolized?
Midazolam
Which of the following is a side effect of etomidate on the cardiovascular system?
Minimal changes in blood pressure
Which of the following is true about etomidate's effect on ventilation?
It stimulates ventilation independent of medullary centers
Which of the following is a principal pharmacologic effect of benzodiazepines?
Anxiolysis
What is the mechanism of action of benzodiazepines?
Enhancement of GABA affinity
Which of the following is a characteristic of diazepam's protein binding?
It has a high degree of protein binding
What is the elimination half-time of diazepam in healthy volunteers?
21 to 37 hours
What is the recommended timeframe for administering diazepam before surgery?
20 minutes before surgery
Which drug is a low-lipid emulsion that does not require preservative but has higher pain on injection?
Ampofol
What is the risk associated with mixing lidocaine and propofol?
Risk of droplets formation
What is the mechanism of action of propofol?
Selective modulator of GABAA receptors
Which drug is associated with a high incidence of pain on injection?
Propofol
Which of the following drugs does not alter tests of coagulation or platelet function?
Thiopental
Which drug is a potent antioxidant and has neuroprotective effects related to its antioxidant properties?
Propofol
Which drug is associated with a significant decrease in intraocular pressure?
Propofol
Which of the following factors contributes to the differences in onset and duration among benzodiazepines?
Pharmacokinetics (uptake, distribution, metabolism and elimination)
Which of the following is a side effect of chronic administration of benzodiazepines?
All of the above
Which drug has a water-soluble form that is stable in aqueous solution and rapidly metabolized?
Midazolam
Which of the following is a characteristic of etomidate's effect on the cardiovascular system?
Etomidate causes minimal changes in heart rate, stroke volume, and cardiac output.
Which of the following is a side effect of chronic administration of benzodiazepines?
Tolerance and potential for abuse
What is the principal limiting aspect of etomidate's use?
Its effect on adrenocortical function
Which of the following is a pharmacologic effect of benzodiazepines?
Anterograde amnesia
Test your knowledge on the pharmacokinetics of etomidate with this quiz. Explore topics such as unionization at physiologic pH, protein binding, metabolism, and more. See how well you understand the rapid effects and redistribution of etomidate within the body.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
