IV Anesthetics PPT 1 Quiz
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Questions and Answers

Which of the following statements about sedatives is correct?

  • Sedatives reduce anxiety.
  • Sedatives induce hypnosis or sleep.
  • Sedatives induce a state of calm or sleep. (correct)
  • Sedatives increase anxiety.

What is the chemical structure of propofol?

  • 2,6-diisopropyl phenol (correct)
  • 10% soybean oil
  • 1.2% purified egg
  • 2.25% glycerol

What is the mechanism of action of propofol?

  • Drug-induced spinal cord depression.
  • Potentiation at glycine receptors.
  • Immobilization caused by spinal cord depression.
  • Selective modulator of GABAA receptors. (correct)

Which drug is associated with a significant decrease in intraocular pressure?

<p>Propofol (A)</p> Signup and view all the answers

Which drug does not alter tests of coagulation or platelet function?

<p>Thiopental (B)</p> Signup and view all the answers

Which drug has been observed to cause anaphylaxis on first exposure, especially in patients with a history of other allergies?

<p>Propofol (C)</p> Signup and view all the answers

Which drug is a selective modulator of GABAA receptors?

<p>Etomidate (B)</p> Signup and view all the answers

Which of the following statements about diazepam is true?

<p>Diazepam is metabolized by hepatic microsomal enzymes. (A)</p> Signup and view all the answers

What is the recommended timeframe for administering diazepam before surgery?

<p>20 minutes (D)</p> Signup and view all the answers

What is the protein binding characteristic of diazepam?

<p>High degree of protein binding (C)</p> Signup and view all the answers

Which of the following is a characteristic of benzodiazepines?

<p>High lipid solubility (C)</p> Signup and view all the answers

Which of the following is a side effect of chronic administration of benzodiazepines?

<p>Fatigue and drowsiness (C)</p> Signup and view all the answers

Which of the following drugs exert synergistic sedative effects with benzodiazepines?

<p>Opioids (A)</p> Signup and view all the answers

Which of the following is true about the pharmacokinetics of midazolam?

<p>Metabolized by CYP3A4 (B)</p> Signup and view all the answers

Which of the following is true about propofol pharmacokinetics?

<p>Propofol is primarily eliminated through the lungs (A)</p> Signup and view all the answers

Which population requires a lower induction dose of propofol?

<p>Elderly (A)</p> Signup and view all the answers

What is the typical concentration of propofol in the blood for conscious sedation?

<p>2 to 6 µg/mL (B)</p> Signup and view all the answers

What is the effect of propofol on cerebral blood flow?

<p>Decreases cerebral blood flow (D)</p> Signup and view all the answers

Which of the following is a characteristic of etomidate metabolism?

<p>Rapidly metabolized by hydrolysis of the ethyl ester side chain to its carboxylic acid ester (B)</p> Signup and view all the answers

Which of the following is a side effect of etomidate on the cardiovascular system?

<p>Minimal changes in heart rate, stroke volume, and cardiac output (C)</p> Signup and view all the answers

Which of the following is a characteristic of etomidate's effect on ventilation?

<p>Depressant effects on ventilation are less than barbiturates and propofol (D)</p> Signup and view all the answers

Which of the following is a principal pharmacologic effect of benzodiazepines?

<p>Anxiolysis, sedation, anticonvulsant, and spinal cord-mediated skeletal muscle relaxation (A)</p> Signup and view all the answers

Which of the following drugs is a prodrug that has a risk of infection, pain on injection, hypertriglyceridemia, and pulmonary embolism?

<p>Fospropofol (A)</p> Signup and view all the answers

What is the chemical structure of propofol?

<p>2,6-diisopropyl phenol (A)</p> Signup and view all the answers

Which of the following drugs is a low-lipid emulsion that does not require a preservative but has a higher pain on injection?

<p>Ampofol (D)</p> Signup and view all the answers

Which of the following is true about the elimination half-time of diazepam in healthy volunteers?

<p>It ranges from 21 to 37 hours. (D)</p> Signup and view all the answers

What is the protein binding characteristic of diazepam?

<p>It has a high degree of protein binding. (B)</p> Signup and view all the answers

What is the recommended timeframe for administering diazepam before surgery?

<p>20 minutes before surgery (C)</p> Signup and view all the answers

Which of the following drugs is associated with a high incidence of pain on injection?

<p>Propofol (D)</p> Signup and view all the answers

Which drug is chemically unrelated to any other drug used for IV induction?

<p>Etomidate (A)</p> Signup and view all the answers

Which drug has been observed to cause bradycardia and asystole in healthy adult patients, even with anticholinergic prophylaxis?

<p>Thiopental (A)</p> Signup and view all the answers

Which drug is a potent antioxidant and has neuroprotective effects related to its antioxidant properties?

<p>Propofol (C)</p> Signup and view all the answers

Which of the following factors contributes to the differences in onset and duration among benzodiazepines?

<p>Pharmacokinetics (uptake, distribution, metabolism and elimination) (C)</p> Signup and view all the answers

Which of the following drugs exerts synergistic sedative effects with benzodiazepines?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a side effect of chronic administration of benzodiazepines?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following drugs has a water-soluble form that is stable in aqueous solution and rapidly metabolized?

<p>Midazolam (A)</p> Signup and view all the answers

Which of the following is a side effect of etomidate on the cardiovascular system?

<p>Minimal changes in blood pressure (B)</p> Signup and view all the answers

Which of the following is true about etomidate's effect on ventilation?

<p>It stimulates ventilation independent of medullary centers (C)</p> Signup and view all the answers

Which of the following is a principal pharmacologic effect of benzodiazepines?

<p>Anxiolysis (A)</p> Signup and view all the answers

What is the mechanism of action of benzodiazepines?

<p>Enhancement of GABA affinity (C)</p> Signup and view all the answers

Which of the following is a characteristic of diazepam's protein binding?

<p>It has a high degree of protein binding (B)</p> Signup and view all the answers

What is the elimination half-time of diazepam in healthy volunteers?

<p>21 to 37 hours (D)</p> Signup and view all the answers

What is the recommended timeframe for administering diazepam before surgery?

<p>20 minutes before surgery (D)</p> Signup and view all the answers

Which drug is a low-lipid emulsion that does not require preservative but has higher pain on injection?

<p>Ampofol (C)</p> Signup and view all the answers

What is the risk associated with mixing lidocaine and propofol?

<p>Risk of droplets formation (D)</p> Signup and view all the answers

What is the mechanism of action of propofol?

<p>Selective modulator of GABAA receptors (A)</p> Signup and view all the answers

Which drug is associated with a high incidence of pain on injection?

<p>Propofol (C)</p> Signup and view all the answers

Which of the following drugs does not alter tests of coagulation or platelet function?

<p>Thiopental (A)</p> Signup and view all the answers

Which drug is a potent antioxidant and has neuroprotective effects related to its antioxidant properties?

<p>Propofol (C)</p> Signup and view all the answers

Which drug is associated with a significant decrease in intraocular pressure?

<p>Propofol (D)</p> Signup and view all the answers

Which of the following factors contributes to the differences in onset and duration among benzodiazepines?

<p>Pharmacokinetics (uptake, distribution, metabolism and elimination) (A)</p> Signup and view all the answers

Which of the following is a side effect of chronic administration of benzodiazepines?

<p>All of the above (D)</p> Signup and view all the answers

Which drug has a water-soluble form that is stable in aqueous solution and rapidly metabolized?

<p>Midazolam (C)</p> Signup and view all the answers

Which of the following is a characteristic of etomidate's effect on the cardiovascular system?

<p>Etomidate causes minimal changes in heart rate, stroke volume, and cardiac output. (C)</p> Signup and view all the answers

Which of the following is a side effect of chronic administration of benzodiazepines?

<p>Tolerance and potential for abuse (D)</p> Signup and view all the answers

What is the principal limiting aspect of etomidate's use?

<p>Its effect on adrenocortical function (B)</p> Signup and view all the answers

Which of the following is a pharmacologic effect of benzodiazepines?

<p>Anterograde amnesia (A)</p> Signup and view all the answers

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