18 Questions
Which type of drugs mainly bind to albumin?
Acidic drugs
What role does protein binding play in the duration of action of a drug?
Prolongs the duration of action
Which barrier serves as a protective barrier for the brain?
Blood-brain barrier
In which form can drugs cross the blood-brain barrier?
Lipid-soluble and unionised form
What type of drugs can readily cross the placental barrier?
Unionised drugs
What does the volume of distribution describe about a drug?
Distribution to multiple compartments
What is the primary focus of Pharmacokinetics?
The effects of the body on the drug
What is the most common route for drug administration?
Oral (by mouth)
What is the purpose of drug distribution within the body?
To send drugs to different parts of the body
Which process involves the breaking down of drugs within the body?
Metabolism
What type of drug administration involves passing the drug across the intestinal epithelium?
Enteral
Which drug administration route does not directly involve crossing membranes?
Intravenous/IV
What is the process by which a drug is moved from its site of administration into the bloodstream?
Absorption
Which of the following routes of administration does not involve absorption?
Intravenous (IV)
What is the term for the fraction of a drug that reaches the blood circulation following administration?
Bioavailability
What occurs when a drug is metabolized in the gut wall and liver before reaching the systemic circulation?
First-pass metabolism
Which of the following factors does NOT influence the rate and extent of absorption?
Concentration gradient
What is the term for the circulation of substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte, and transport back to the liver?
Enterohepatic circulation
Learn about pharmacology principles, drug administration, absorption, distribution, metabolism, and excretion from slides by Prof. Maxine Gossell-Williams. Explore the definitions, concepts, and objectives related to pharmacokinetics.
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