Pharmacokinetics Lecture by Prof. Maxine Gossell-Williams

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Questions and Answers

Which type of drugs mainly bind to albumin?

  • Lipid-soluble drugs
  • Acidic drugs (correct)
  • Basic drugs
  • Unionised drugs

What role does protein binding play in the duration of action of a drug?

  • Accelerates the metabolism of the drug
  • Prolongs the duration of action (correct)
  • Has no effect on duration of action
  • Shortens the duration of action

Which barrier serves as a protective barrier for the brain?

  • Blood-brain barrier (correct)
  • Molecular weight barrier
  • Lipid solubility barrier
  • Ionisation barrier

In which form can drugs cross the blood-brain barrier?

<p>Lipid-soluble and unionised form (D)</p> Signup and view all the answers

What type of drugs can readily cross the placental barrier?

<p>Unionised drugs (A)</p> Signup and view all the answers

What does the volume of distribution describe about a drug?

<p>Distribution to multiple compartments (C)</p> Signup and view all the answers

What is the primary focus of Pharmacokinetics?

<p>The effects of the body on the drug (B)</p> Signup and view all the answers

What is the most common route for drug administration?

<p>Oral (by mouth) (C)</p> Signup and view all the answers

What is the purpose of drug distribution within the body?

<p>To send drugs to different parts of the body (A)</p> Signup and view all the answers

Which process involves the breaking down of drugs within the body?

<p>Metabolism (B)</p> Signup and view all the answers

What type of drug administration involves passing the drug across the intestinal epithelium?

<p>Enteral (D)</p> Signup and view all the answers

Which drug administration route does not directly involve crossing membranes?

<p>Intravenous/IV (B)</p> Signup and view all the answers

What is the process by which a drug is moved from its site of administration into the bloodstream?

<p>Absorption (C)</p> Signup and view all the answers

Which of the following routes of administration does not involve absorption?

<p>Intravenous (IV) (C)</p> Signup and view all the answers

What is the term for the fraction of a drug that reaches the blood circulation following administration?

<p>Bioavailability (B)</p> Signup and view all the answers

What occurs when a drug is metabolized in the gut wall and liver before reaching the systemic circulation?

<p>First-pass metabolism (A)</p> Signup and view all the answers

Which of the following factors does NOT influence the rate and extent of absorption?

<p>Concentration gradient (C)</p> Signup and view all the answers

What is the term for the circulation of substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte, and transport back to the liver?

<p>Enterohepatic circulation (C)</p> Signup and view all the answers

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