Pharmacokinetics Lecture
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Questions and Answers

What form of the drug is available for action, metabolism, and excretion?

  • Protein-bound fraction
  • Plasma protein-bound fraction
  • Bound fraction
  • Free and unbound fraction (correct)
  • Which type of drugs bind mainly to albumin?

  • Neutral drugs
  • Acidic drugs (correct)
  • Neutral and basic drugs
  • Basic drugs
  • What prolongs the duration of action of a drug?

  • Protein binding (correct)
  • Distribution
  • Metabolism
  • Excretion
  • What must drugs be in order to cross the blood-brain barrier?

    <p>Lipid soluble and unionized</p> Signup and view all the answers

    Which barrier allows lipid-soluble unionized drugs to readily cross?

    <p>Placental barrier</p> Signup and view all the answers

    What does volume of distribution describe?

    <p>How extensively a drug is distributed compared to plasma</p> Signup and view all the answers

    What is the term used to describe the movement of a drug from its site of administration into the bloodstream?

    <p>Absorption by passive diffusion</p> Signup and view all the answers

    Which route of absorption compensates for first-pass metabolism by ensuring 100% bioavailability?

    <p>Intravenous injection</p> Signup and view all the answers

    What does the term 'enterohepatic circulation' refer to in drug metabolism?

    <p>Circulation from liver to bile to the small intestine</p> Signup and view all the answers

    How can first-pass metabolism be compensated for with some drugs?

    <p>Increasing the dose</p> Signup and view all the answers

    Which route of drug administration may result in low bioavailability due to metabolism in the gut wall and liver before systemic circulation?

    <p>Oral administration</p> Signup and view all the answers

    What term describes the dispersion of drugs from the bloodstream to other tissues and their site of action?

    <p>Distribution</p> Signup and view all the answers

    What is the definition of pharmacokinetics?

    <p>The effect of the body on drugs</p> Signup and view all the answers

    Which route of drug administration involves passing the drug through the cheeks?

    <p>Sublingual</p> Signup and view all the answers

    What is pharmacology primarily concerned with?

    <p>Drug interactions with living systems</p> Signup and view all the answers

    Which of the following is NOT a route of enteral drug administration?

    <p>Intravenous</p> Signup and view all the answers

    What is the role of metabolism in pharmacokinetics?

    <p>Breaking down drugs</p> Signup and view all the answers

    Which barrier must a drug pass through during enteral drug administration?

    <p>Intestinal epithelium</p> Signup and view all the answers

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