Pharmacokinetics Lecture

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What form of the drug is available for action, metabolism, and excretion?

Protein-bound fraction

Plasma protein-bound fraction

Bound fraction

Free and unbound fraction (correct)

Which type of drugs bind mainly to albumin?

Neutral drugs

Acidic drugs (correct)

Neutral and basic drugs

Basic drugs

What prolongs the duration of action of a drug?

Protein binding (correct)

Distribution

Metabolism

Excretion

What must drugs be in order to cross the blood-brain barrier?

Lipid soluble and unionized Signup and view all the answers

Which barrier allows lipid-soluble unionized drugs to readily cross?

Placental barrier Signup and view all the answers

What does volume of distribution describe?

How extensively a drug is distributed compared to plasma Signup and view all the answers

What is the term used to describe the movement of a drug from its site of administration into the bloodstream?

Absorption by passive diffusion Signup and view all the answers

Which route of absorption compensates for first-pass metabolism by ensuring 100% bioavailability?

Intravenous injection Signup and view all the answers

What does the term 'enterohepatic circulation' refer to in drug metabolism?

Circulation from liver to bile to the small intestine Signup and view all the answers

How can first-pass metabolism be compensated for with some drugs?

Increasing the dose Signup and view all the answers

Which route of drug administration may result in low bioavailability due to metabolism in the gut wall and liver before systemic circulation?

Oral administration Signup and view all the answers

What term describes the dispersion of drugs from the bloodstream to other tissues and their site of action?

Distribution Signup and view all the answers

What is the definition of pharmacokinetics?

The effect of the body on drugs Signup and view all the answers

Which route of drug administration involves passing the drug through the cheeks?

Sublingual Signup and view all the answers

What is pharmacology primarily concerned with?

Drug interactions with living systems Signup and view all the answers

Which of the following is NOT a route of enteral drug administration?

Intravenous Signup and view all the answers

What is the role of metabolism in pharmacokinetics?

Breaking down drugs Signup and view all the answers

Which barrier must a drug pass through during enteral drug administration?

Intestinal epithelium Signup and view all the answers