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Questions and Answers
What does 'Liberation' refer to in the LADME model?
What does 'Liberation' refer to in the LADME model?
- Release of drug from formulation (correct)
- Chemical conversion of active drug to inactive metabolites
- Movement of drug throughout the body
- Elimination of drug from the body
Which parameter of the LADME model involves the ability of the drug to move throughout the body to tissue cells?
Which parameter of the LADME model involves the ability of the drug to move throughout the body to tissue cells?
- Absorption
- Excretion
- Distribution (correct)
- Metabolism
What is the process of 'Metabolism' in the LADME model?
What is the process of 'Metabolism' in the LADME model?
- Chemical conversion of active drug to inactive metabolites (correct)
- Release of drug from formulation
- Elimination of drug from the body
- Speed and fraction of dose that enters circulation
Which group of drugs is fully dissociated at blood pH of 7.4?
Which group of drugs is fully dissociated at blood pH of 7.4?
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At what pH do weak acids have significant amounts of unionized form present?
At what pH do weak acids have significant amounts of unionized form present?
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Which drugs can act as weak bases with pKa < 10?
Which drugs can act as weak bases with pKa < 10?
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What type of drugs tend to be significantly ionized at blood pH?
What type of drugs tend to be significantly ionized at blood pH?
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Which drugs do not carry a charge?
Which drugs do not carry a charge?
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