Pharmacokinetics and LADME Model Quiz
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Questions and Answers

What does 'Liberation' refer to in the LADME model?

  • Release of drug from formulation (correct)
  • Chemical conversion of active drug to inactive metabolites
  • Movement of drug throughout the body
  • Elimination of drug from the body

    • Which parameter of the LADME model involves the ability of the drug to move throughout the body to tissue cells?

  • Absorption
  • Excretion
  • Distribution (correct)
  • Metabolism

    • What is the process of 'Metabolism' in the LADME model?

  • Chemical conversion of active drug to inactive metabolites (correct)
  • Release of drug from formulation
  • Elimination of drug from the body
  • Speed and fraction of dose that enters circulation

    • Which group of drugs is fully dissociated at blood pH of 7.4?

    <p>Strong acids</p> Signup and view all the answers

    At what pH do weak acids have significant amounts of unionized form present?

    <p>pH 7.4</p> Signup and view all the answers

    Which drugs can act as weak bases with pKa < 10?

    <p>Anesthetics</p> Signup and view all the answers

    What type of drugs tend to be significantly ionized at blood pH?

    <p>Basic drugs</p> Signup and view all the answers

    Which drugs do not carry a charge?

    <p>Neutral drugs</p> Signup and view all the answers

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