8 Questions
What does 'Liberation' refer to in the LADME model?
Release of drug from formulation
Which parameter of the LADME model involves the ability of the drug to move throughout the body to tissue cells?
Distribution
What is the process of 'Metabolism' in the LADME model?
Chemical conversion of active drug to inactive metabolites
Which group of drugs is fully dissociated at blood pH of 7.4?
Strong acids
At what pH do weak acids have significant amounts of unionized form present?
pH 7.4
Which drugs can act as weak bases with pKa < 10?
Anesthetics
What type of drugs tend to be significantly ionized at blood pH?
Basic drugs
Which drugs do not carry a charge?
Neutral drugs
Test your understanding of pharmacokinetics and the LADME model with this quiz. Explore the parameters that affect drug behavior, including liberation, absorption, distribution, metabolism, and excretion.
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