Pharmacokinetic Parameters Quiz

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Questions and Answers

What is the peak plasma concentration given F = 0.9, Dose = 600 mg, ka = 1.0 hr^-1, kel = 0.15 hr^-1, and Vd = 30 liter?

  • $15.3$ mg/L
  • $12.9$ mg/L (correct)
  • $10.5$ mg/L
  • $8.7$ mg/L

If ka = 0.2 hr^-1 instead of 1.0 hr^-1, what is the peak plasma concentration given F = 0.9, Dose = 600 mg, kel = 0.15 hr^-1, and Vd = 30 liter?

  • $5.4$ mg/L
  • $7.6$ mg/L (correct)
  • $6.8$ mg/L
  • $9.2$ mg/L

What is the value of T peak given ka = 1.0 hr^-1 and kel = 0.15 hr^-1?

  • $3.45$ hours
  • $1.67$ hours
  • $2.23$ hours (correct)
  • $4.56$ hours

If kel = 0.2 hr^-1 instead of 0.15 hr^-1, what is the value of T peak given ka = 1.0 hr^-1?

<p>$1.92$ hours (C)</p> Signup and view all the answers

If the dose is increased to 800 mg, what is the new peak plasma concentration given F = 0.9, ka = 1.0 hr^-1, kel = 0.15 hr^-1, and Vd = 30 liter?

<p>$17.2$ mg/L (D)</p> Signup and view all the answers

Flashcards

What is peak plasma concentration (Cmax)?

The maximum drug concentration observed in plasma after administration.

What is the peak plasma concentration?

Plasma concentration is $12.9$ mg/L given F = 0.9, Dose = 600 mg, ka = 1.0 hr^-1, kel = 0.15 hr^-1, and Vd = 30 liter.

What’s the peak plasma conc. if ka = 0.2 hr^-1?

Plasma concentration is $7.6$ mg/L.

What is T peak given ka = 1.0 hr^-1 and kel = 0.15 hr^-1?

Time to reach peak concentration is $2.23$ hours.

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What's the new peak if the dose is increased to 800 mg?

New peak plasma concentration is $17.2$ mg/L.

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