Pharmacokinetic Models Quiz

Play an AI-generated podcast conversation about this lesson

Which process is riboflavin supposed to exhibit?

Zero-order kinetics

First-order kinetics

Capacity limited elimination

Capacity limited absorption (correct)

What happens to the elimination half-life as the dose of a drug exhibiting capacity-limited elimination is increased?

It remains constant

It becomes proportional to the dose

It decreases

It becomes greater (correct)

What characteristics are exhibited by drugs that demonstrate saturation kinetics?

Apparent first-order kinetics (correct)

No saturation at higher doses

Linear dose-independent kinetics

Zero-order kinetics at all doses

What does the Michaelis-Menten equation commonly describe?

Kinetics of in-vitro, in-situ, and certain in-vivo processes Signup and view all the answers

When are first-order kinetics expected at low plasma concentration?

When Km is larger than the plasma concentration achieved Signup and view all the answers

What happens to first-order kinetics at high plasma concentration?

They are not seen Signup and view all the answers

At normal therapeutic concentrations, what type of rate processes do most drugs follow?

First-order rate processes Signup and view all the answers

Which drugs tend to saturate the hepatic mixed function oxidases at higher therapeutic doses?

Phenytoin and salicylates Signup and view all the answers

What happens to elimination kinetics with very small doses of drugs that tend to saturate enzymatic processes?

They become apparent first-order kinetics Signup and view all the answers

What happens to drug concentration in the blood once an elimination process is saturated?

It increases rapidly Signup and view all the answers

What does a plot of the areas under the plasma level-time curves at various doses indicate if it's linear?

The drug follows dose-independent kinetics Signup and view all the answers

What does Eqn 4 describe according to the text?

First order kinetics Signup and view all the answers

What term is used to describe the non-linear pharmacokinetic behavior observed when different doses or multiple doses of a drug are given?

Dose-dependent pharmacokinetics Signup and view all the answers

Which specialized process may become saturated when drugs are given at therapeutic levels?

Zero-order kinetics Signup and view all the answers

What can cause deviations from the linear pharmacokinetic profile observed with single low doses of a drug?

Increased doses or chronic medication Signup and view all the answers

Which drugs may cause alterations in renal drug excretion and exhibit non-linearity at high doses?

Aminoglycosides Signup and view all the answers

What does the term 'capacity limited elimination' refer to in pharmacokinetics?

Saturation of enzymes and active transport systems for the drug Signup and view all the answers

What may alter biliary excretion and cause non-linear pharmacokinetic behavior?

Obstruction of the bile duct Signup and view all the answers

What is the term used for the transformation from essentially first-order kinetics to a mixture of first-order and zero-order rate processes?

Mixed-order kinetics Signup and view all the answers

What processes of drug involve enzymes or carrier-mediated systems?

Biotransformation and excretion Signup and view all the answers

What is another term for non-linear pharmacokinetic behavior observed with different doses or multiple doses of a drug?

Dose-dependent kinetics Signup and view all the answers

What may cause deviations from the linear pharmacokinetic profile observed with single low doses of a drug?

Chronic medication Signup and view all the answers