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Questions and Answers
Which process is riboflavin supposed to exhibit?
Which process is riboflavin supposed to exhibit?
- Zero-order kinetics
- First-order kinetics
- Capacity limited elimination
- Capacity limited absorption (correct)
What happens to the elimination half-life as the dose of a drug exhibiting capacity-limited elimination is increased?
What happens to the elimination half-life as the dose of a drug exhibiting capacity-limited elimination is increased?
- It remains constant
- It becomes proportional to the dose
- It decreases
- It becomes greater (correct)
What characteristics are exhibited by drugs that demonstrate saturation kinetics?
What characteristics are exhibited by drugs that demonstrate saturation kinetics?
- Apparent first-order kinetics (correct)
- No saturation at higher doses
- Linear dose-independent kinetics
- Zero-order kinetics at all doses
What does the Michaelis-Menten equation commonly describe?
What does the Michaelis-Menten equation commonly describe?
When are first-order kinetics expected at low plasma concentration?
When are first-order kinetics expected at low plasma concentration?
What happens to first-order kinetics at high plasma concentration?
What happens to first-order kinetics at high plasma concentration?
At normal therapeutic concentrations, what type of rate processes do most drugs follow?
At normal therapeutic concentrations, what type of rate processes do most drugs follow?
Which drugs tend to saturate the hepatic mixed function oxidases at higher therapeutic doses?
Which drugs tend to saturate the hepatic mixed function oxidases at higher therapeutic doses?
What happens to elimination kinetics with very small doses of drugs that tend to saturate enzymatic processes?
What happens to elimination kinetics with very small doses of drugs that tend to saturate enzymatic processes?
What happens to drug concentration in the blood once an elimination process is saturated?
What happens to drug concentration in the blood once an elimination process is saturated?
What does a plot of the areas under the plasma level-time curves at various doses indicate if it's linear?
What does a plot of the areas under the plasma level-time curves at various doses indicate if it's linear?
What does Eqn 4 describe according to the text?
What does Eqn 4 describe according to the text?
What term is used to describe the non-linear pharmacokinetic behavior observed when different doses or multiple doses of a drug are given?
What term is used to describe the non-linear pharmacokinetic behavior observed when different doses or multiple doses of a drug are given?
Which specialized process may become saturated when drugs are given at therapeutic levels?
Which specialized process may become saturated when drugs are given at therapeutic levels?
What can cause deviations from the linear pharmacokinetic profile observed with single low doses of a drug?
What can cause deviations from the linear pharmacokinetic profile observed with single low doses of a drug?
Which drugs may cause alterations in renal drug excretion and exhibit non-linearity at high doses?
Which drugs may cause alterations in renal drug excretion and exhibit non-linearity at high doses?
What does the term 'capacity limited elimination' refer to in pharmacokinetics?
What does the term 'capacity limited elimination' refer to in pharmacokinetics?
What may alter biliary excretion and cause non-linear pharmacokinetic behavior?
What may alter biliary excretion and cause non-linear pharmacokinetic behavior?
What is the term used for the transformation from essentially first-order kinetics to a mixture of first-order and zero-order rate processes?
What is the term used for the transformation from essentially first-order kinetics to a mixture of first-order and zero-order rate processes?
What processes of drug involve enzymes or carrier-mediated systems?
What processes of drug involve enzymes or carrier-mediated systems?
What is another term for non-linear pharmacokinetic behavior observed with different doses or multiple doses of a drug?
What is another term for non-linear pharmacokinetic behavior observed with different doses or multiple doses of a drug?
What may cause deviations from the linear pharmacokinetic profile observed with single low doses of a drug?
What may cause deviations from the linear pharmacokinetic profile observed with single low doses of a drug?
