Pharmacognosy Overview and Crude Drugs Classification

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Questions and Answers

The British Herbal Pharmacopoeia provides detailed information on the chemical constituents present in crude drugs.

False (B)

Taxonomical classification is based on phytogenetical relations in plants.

True (A)

Morphological classification takes into account the chemical nature of the drug.

False (B)

Morphological classification helps in identifying and detecting adulteration.

<p>True (A)</p> Signup and view all the answers

An example of a simple leaf is Digitalis purpurea.

<p>True (A)</p> Signup and view all the answers

Organoleptic properties are irrelevant to the classification of drugs.

<p>False (B)</p> Signup and view all the answers

Pharmacological classification arranges drugs based on their appearance and structure.

<p>False (B)</p> Signup and view all the answers

Drugs like digitalis, squill, and strophanthus are classified together due to their anti-inflammatory action.

<p>False (B)</p> Signup and view all the answers

The European Pharmacopoeia is regarded as very scientific and provides insights at the molecular level.

<p>False (B)</p> Signup and view all the answers

One disadvantage of morphological classification is the lack of correlation between chemical constituents and therapeutic actions.

<p>True (A)</p> Signup and view all the answers

The family of the plant Rosa canina is Rosaceae.

<p>True (A)</p> Signup and view all the answers

The morphological classification includes drugs arranged by the part used and their physical characteristics.

<p>True (A)</p> Signup and view all the answers

Classification based on pharmacological action is the least followed method in pharmacology.

<p>False (B)</p> Signup and view all the answers

The item Adhatoda is classified as an anti-septic drug.

<p>False (B)</p> Signup and view all the answers

All anti-oxidant drugs listed include Guggul and Amla.

<p>True (A)</p> Signup and view all the answers

Cinchona and Artemisia are used in the classification of anti-cancer drugs.

<p>False (B)</p> Signup and view all the answers

Altitude is an important climatic variable for the cultivation of medicinal plants, particularly at levels between 1500 and 2500.

<p>True (A)</p> Signup and view all the answers

Rainfall is not considered a crucial factor for the favorable development of most medicinal plants.

<p>False (B)</p> Signup and view all the answers

The pH range best suited for maximum plant nutrient availability is between 5.5 to 6.5.

<p>False (B)</p> Signup and view all the answers

Only desired species can be harvested in cultivated settings, ensuring uniform quality.

<p>True (A)</p> Signup and view all the answers

Cold temperatures are predominantly required for the cultivation of coffee and tea.

<p>False (B)</p> Signup and view all the answers

Soil quality significantly affects the growth of medicinal plants.

<p>True (A)</p> Signup and view all the answers

Fertilizers are unnecessary for the development and growth of plants.

<p>False (B)</p> Signup and view all the answers

The collection of undeclared plants during the incorrect season can result in the loss of valuable plant activity.

<p>True (A)</p> Signup and view all the answers

Carbon, oxygen, hydrogen, and calcium are acquired by plants from soil.

<p>False (B)</p> Signup and view all the answers

Gibberellins promote root growth through cell differentiation.

<p>False (B)</p> Signup and view all the answers

Auxins are classified as secondary nutrients in plant growth.

<p>False (B)</p> Signup and view all the answers

Ethylene is found in plants as a volatile gas.

<p>True (A)</p> Signup and view all the answers

Calcium is considered a primary essential macro-element for plant growth.

<p>False (B)</p> Signup and view all the answers

Plant growth regulators can affect physiological processes in high concentrations only.

<p>False (B)</p> Signup and view all the answers

Cytokinins retard the aging process in plants by promoting chlorophyll breakdown.

<p>False (B)</p> Signup and view all the answers

Drugs can be collected from either cultivated or wild plants depending on the growing conditions.

<p>True (A)</p> Signup and view all the answers

Fruits are best collected in the winter.

<p>False (B)</p> Signup and view all the answers

Leaves are collected during the flowering stage.

<p>True (A)</p> Signup and view all the answers

Digitalis contains higher amounts of active constituents in the morning.

<p>False (B)</p> Signup and view all the answers

Seeds should be collected when the plant is in a dry condition.

<p>True (A)</p> Signup and view all the answers

Drugs containing alkaloids are best collected from November to January.

<p>False (B)</p> Signup and view all the answers

Roots are collected after the flowering period.

<p>False (B)</p> Signup and view all the answers

Bark is collected in the fall.

<p>False (B)</p> Signup and view all the answers

Medicinal plants should be completely collected by hand.

<p>True (A)</p> Signup and view all the answers

Caffeine is an example of a true alkaloid.

<p>False (B)</p> Signup and view all the answers

Alkaloids are more abundant in dicots compared to monocots.

<p>True (A)</p> Signup and view all the answers

Ephedrine is an alkaloid that occurs primarily in fungi.

<p>True (A)</p> Signup and view all the answers

Plants that produce alkaloids may have a bitterness that helps protect them against herbivores.

<p>True (A)</p> Signup and view all the answers

Cinchona is a plant known for its rich alkaloid content, specifically quinine.

<p>True (A)</p> Signup and view all the answers

Tobacco is utilized as a source of nitrogen in case of nitrogen deficiency in plants.

<p>False (B)</p> Signup and view all the answers

The majority of alkaloids are found in the flowering tops of plants.

<p>False (B)</p> Signup and view all the answers

Cinchonidine and cinchonine are derived from the plant Cinchona.

<p>True (A)</p> Signup and view all the answers

Flashcards

Taxonomical Classification

A system of classifying crude drugs based on their botanical relationships (phytogenetical relations).

Morphological Classification - Limitation

Doesn't consider the chemical composition of the drug.

Morphological Classification

A system of arranging crude drugs based on parts used and physical characteristics.

Taxonomical Classification - Merits

Helpful for studying crude drugs, provides easy identification, and shows links between chemical constituents and drug activity.

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British Herbal Pharmacopoeia - Merit

Offers quick access to information, suitable for reference.

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British Herbal Pharmacopoeia - Demerit

Doesn't mention or categorize the chemical constituents in crude drugs.

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Crude Drug Classification - Importance

Systems for classifying plant-derived medicines are useful for studying similarities and differences.

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Classification Types

Taxonomic classification, focusing on plant relationships; Morphological classification, focusing on physical traits.

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Pharmacological Classification

A method of classifying drugs based on their effects on the body (e.g., cardiotonic, anti-inflammatory).

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Crude Drug

Unprocessed plant material used in traditional medicine.

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Cardiotonic Drug Example

Drugs like digitalis, squill, or strophanthus that strengthen heart action.

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Example of Anti-allergic Drug

Ephedrine, Vasaka, and Tussilaginis, drugs with anti-allergic functions.

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Adulteration Detection

Using morphological characteristics to discover if a substance has been mislabeled or contains extra materials.

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Merit of Pharmacological Classification

This system of classification allows access to particular drugs that might be unavailable locally.

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Drawback of Morphological Classification

There is no connection between a drug's structure and its medicinal properties.

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Cultivated Herb Advantages

Cultivated herbs offer consistent quality, improved transport, and controlled growing conditions, making them reliable sources.

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Collector Ignorance

Mistakes in herb collection (like mixing species or wrong seasons) lead to loss of medicinal activity.

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Climate's Effect on Cultivation

Climate, including altitude and temperature, significantly impacts medicinal plant growth and quality.

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Altitude and Plant Types

Different medicinal plants thrive at specific altitudes (e.g., tea at 2500-3000m).

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Soil's Role in Cultivation

Soil quality, including pH and fertility, is crucial for plant growth, affecting yield and medicinal properties.

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Optimal Soil pH

Medicinal plants generally thrive in soil with a pH between 6.5 and 7.5.

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Fertilizers' Purpose

Fertilizers provide essential nutrients to promote plant growth and development.

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Temperature Effects

Extreme temperatures can damage herbs and affect the quality and quantity of their medicinal contents.

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Essential Macro-elements

Nutrients that plants need in large amounts for growth. These are nitrogen (N), phosphorus (P), and potassium (K).

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Trace Elements

Elements that are essential for plant growth but required in very small quantities. Examples include copper, manganese, boron, molybdenum, and zinc.

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Cell Division

The process where a single cell divides into two or more cells. Plant growth regulators can influence this process.

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Cell Differentiation

The process where cells develop specialized functions, like forming roots, stems, or leaves. Plant growth regulators can influence this process.

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Auxins

Plant hormones that promote growth of coleoptiles, roots, and overall plant length. Examples include indoleacetic acid (IAA), indole butyric acid (IBA), and naphthaleneacetic acid (NAA).

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Gibberellins (GA)

Plant hormones that promote stem growth through cell division, also impacting fruit growth and seed production. Examples include GA3 and GA4.

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Cytokinins

Plant hormones that stimulate cell division and growth of leaves. They also promote axillary and lateral bud growth and fruit maturity. They slow down the aging process.

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Abscisic Acid (ABA)

Plant hormones that regulate responses to stress, like drought. They also control seed dormancy and leaf fall.

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Best Time for Collection

The optimal time to collect medicinal plants to ensure the highest quality and potency of their active constituents.

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Fruits: Optimal Collection Time

Fruits are best collected during the summer when they are fully ripe and mature, with emphasis on collecting both the fruit and seeds.

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Leaves: Optimal Collection Time

Leaves are best collected during the summer, specifically during the flowering stage, when they are rich in medicinal compounds.

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Seeds: Optimal Collection Time

Seeds are best collected in the fall after they have fully matured and dried, usually when the plant is in a dry condition.

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Roots: Optimal Collection Time

Roots are best collected at the end of the vegetative period, before the plant flowers, as they are richest in medicinal compounds during this time.

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Digitalis: Time of Day for Collection

The concentration of active constituents in Digitalis fluctuates throughout the day, reaching the highest point in the afternoon.

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Importance of Maturity

The stage of maturity of a plant can significantly influence the quantity and quality of its active constituents. Different parts of the plant are best collected at different stages.

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Hand Collection: Why Important

Medicinal plants are typically best collected by hand to prevent contamination, damage, and ensure the highest quality of the raw material.

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Pseudo Alkaloids

Compounds containing nitrogen but not derived from amino acids. They lack a true alkaloid structure and might be synthesized from other compounds.

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Example of a Pseudo Alkaloid

Caffeine is a pseudo alkaloid. It is derived from xanthine, not an amino acid.

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True Alkaloids

Nitrogen-containing compounds derived from amino acids, synthesized by plants.

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Example of a True Alkaloid

Quinine, a compound found in the Cinchona bark, is a true alkaloid derived from tryptophan.

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Proto Alkaloids

Simple nitrogen-containing compounds not derived from amino acids, similar to pseudo alkaloids.

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Plant Distribution of Alkaloids

Alkaloids are more common in higher plants, especially dicots. Certain families (like Apocynaceae or Solanaceae) are particularly rich in alkaloids.

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Alkaloid Functions in Plants

Alkaloids can protect plants from insects and herbivores, serve as a nitrogen source, or act as growth regulators.

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Examples of Alkaloid Functions in Plants

Nicotine in tobacco acts as a defense against herbivores. Ergotamine from fungi can be used as a growth regulator in some systems.

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Study Notes

Pharmacognosy Overview

  • Pharmacognosy is the study of drugs derived from natural sources
  • It involves the physical, chemical, and biological aspects of medicinal plants and other natural products
  • It's a crucial subject that links the source of drugs with their pharmacological properties

Crude Drugs

  • Crude drugs are raw materials extracted from plants
  • Crude drugs are categorized based on various factors

Classification of Crude Drugs

  • Morphological classification arranges drugs according to their physical characteristics
  • Pharmacological classification groups drugs based on their therapeutic effects
  • Chemical classification arranges drugs based on the chemical compounds they contain

Methods of Study

  • Microscopy—examines the structural components of crude drugs
  • Physicochemical methods for identifying the properties of drugs
  • Chemical analysis to quantify active compounds

Cultivation, Collection, and Processing

  • Cultivation procedures for specific plant species must be tailored
  • Collection methods must be chosen based on the desired source quality
  • Drying methods preserve the crude components for further processing

Plant Growth Regulators

  • Plant growth regulators are important because they control and influence plant development
  • Plant growth regulators involve synthetic and natural plant hormones

Time of the Year

  • Proper time of the year is critical to harvesting plant parts with maximum potency
  • Factors to consider include climate, weather conditions, seasonal growth patterns, and plant maturity

Storage of Crude Drugs

  • Proper storage is crucial to preserving the chemical compounds and biological activity of crude drugs
  • Storage conditions must control factors such as humidity, temperature, and light

Evaluation of Medicinal Plants

  • Thorough plant identification and study are foundational to understanding their properties
  • Plant extracts or isolated compounds undergo evaluation in the lab for their therapeutic properties
  • Extraction methods, purity, safety, and efficacy are all essential qualities of a medicinally active product

Alkaloids

  • Alkaloids are a wide class of compounds containing nitrogen
  • Alkaloids are present in various concentrations across different plant parts and species
  • Alkaloids can be grouped based on their effects, chemical structures, or other factors

Types of Alkaloids

  • True alkaloids are organic bases with nitrogen as part of a heterocyclic ring
  • Protoalkaloids have nitrogen as part of a heterocyclic ring but they are not basic
  • Pseudoalkaloids do not structurally have a nitrogen in a heterocyclic ring

Occurrence and Distribution of Plant Components

  • All parts of plants; roots, stems, flowers, seeds, leaves, bark and fruits may contain medicinal compounds
  • Different plant families may exhibit significant amounts of alkaloids in different parts
  • Proper identification is critical to ensure quality and safety

Functions of Alkaloids in Plants

  • Alkaloids serve as protective compounds that repel insects and herbivores
  • They can also act as sources of nitrogen when needed
  • Some alkaloids also function as growth regulators within plant metabolic systems

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