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Questions and Answers
How does dimercaprol (BAL) function in the body?
How does dimercaprol (BAL) function in the body?
- Neutralizes gastric acid secretion
- Increases the permeability of bacterial plasma membrane
- Chelates arsenic, mercury, and copper (correct)
- Inhibits protein synthesis in bacteria by binding to 50S ribosomal subunit
What is the mechanism of action of protamine?
What is the mechanism of action of protamine?
- Increases the permeability of bacterial plasma membrane
- Antagonizes heparin by its alkaline and positive charge (correct)
- Inhibits protein synthesis in bacteria by binding to 50S ribosomal subunit
- Chelates calcium, lead, and digitalis
What is the primary function of EDTA in pharmacodynamics?
What is the primary function of EDTA in pharmacodynamics?
- Inhibits protein synthesis in bacteria by binding to 30S ribosomal subunit
- Increases the permeability of bacterial plasma membrane
- Neutralizes gastric acid secretion
- Chelates calcium, lead, and digitalis (correct)
What is the role of penicillamine in pharmacodynamics?
What is the role of penicillamine in pharmacodynamics?
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What is the action of polymixins and amphotericin B on bacteria?
What is the action of polymixins and amphotericin B on bacteria?
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Study Notes
Chelating Agents
- Dimercaprol (BAL) is a chelating agent used to treat heavy metal poisoning by binding to metals, such as arsenic, mercury, and lead, and forming a complex that can be excreted from the body.
Anticoagulant Reversal
- Protamine is a drug used to reverse the effects of heparin, a blood thinner, by binding to it and neutralizing its anticoagulant activity.
Chelating Agents
- EDTA (ethylenediaminetetraacetic acid) is a chelating agent used to treat hypercalcemia and heavy metal poisoning by binding to calcium and heavy metals, such as lead, and removing them from the body.
Rheumatoid Arthritis Treatment
- Penicillamine is a chelating agent used to treat rheumatoid arthritis by reducing inflammation and joint damage, possibly by removing excess copper from the body.
Antibacterial Agents
- Polymyxins are antibacterial agents that disrupt the outer membrane of Gram-negative bacteria, ultimately leading to bacterial cell death.
- Amphotericin B is an antifungal agent that forms pores in the fungal cell membrane, allowing ions to leak out and ultimately leading to fungal cell death.
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