5 Questions
How does dimercaprol (BAL) function in the body?
Chelates arsenic, mercury, and copper
What is the mechanism of action of protamine?
Antagonizes heparin by its alkaline and positive charge
What is the primary function of EDTA in pharmacodynamics?
Chelates calcium, lead, and digitalis
What is the role of penicillamine in pharmacodynamics?
Chelates copper and used in treatment of Wilson’s disease
What is the action of polymixins and amphotericin B on bacteria?
Increase the permeability of bacterial plasma membrane
Study Notes
Chelating Agents
- Dimercaprol (BAL) is a chelating agent used to treat heavy metal poisoning by binding to metals, such as arsenic, mercury, and lead, and forming a complex that can be excreted from the body.
Anticoagulant Reversal
- Protamine is a drug used to reverse the effects of heparin, a blood thinner, by binding to it and neutralizing its anticoagulant activity.
Chelating Agents
- EDTA (ethylenediaminetetraacetic acid) is a chelating agent used to treat hypercalcemia and heavy metal poisoning by binding to calcium and heavy metals, such as lead, and removing them from the body.
Rheumatoid Arthritis Treatment
- Penicillamine is a chelating agent used to treat rheumatoid arthritis by reducing inflammation and joint damage, possibly by removing excess copper from the body.
Antibacterial Agents
- Polymyxins are antibacterial agents that disrupt the outer membrane of Gram-negative bacteria, ultimately leading to bacterial cell death.
- Amphotericin B is an antifungal agent that forms pores in the fungal cell membrane, allowing ions to leak out and ultimately leading to fungal cell death.
Test your knowledge of pharmacodynamics with this quiz based on lectures by Dr. Ghada Samy. Learn about the biochemical and pharmacological effects of drugs, their mechanisms of action, and how drugs produce their effects through different mechanisms.
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