Pharmacodynamics Lecture by Dr. Ghada Samy

Drug Actions and Mechanisms

• Physical Action Drug: Activated charcoal acts by adsorbing toxins and chemicals in the gastrointestinal tract, thus preventing their absorption into the body.

Specific Drug Treatments

• Wilson's Disease Treatment: Penicillamine is utilized for treating Wilson's disease by chelating excess copper, facilitating its excretion through urine.

Anticoagulant Antagonists

• Heparin Antagonist: Protamine sulfate is the drug that acts as an antagonist to heparin, reversing its anticoagulant effects effectively.

Bacterial Membrane Permeability

• Membrane Permeability Increasing Drug: Polymyxin B operates by increasing the permeability of the bacterial plasma membrane, leading to cell death and is primarily effective against Gram-negative bacteria.

Antibiotic Protein Synthesis Inhibitors

• Protein Synthesis Inhibition: Erythromycin inhibits bacterial protein synthesis by binding to the 50 S subunit of the ribosome, disrupting peptide chain elongation.