Pharmacodynamics: Kinase Linked Receptors

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Questions and Answers

Which of the following receptors is involved in regulating cardiac muscle contraction?

  • Thyroid hormone receptor
  • Beta 1 adrenergic receptor (correct)
  • Vitamin D receptor
  • Estrogen receptor

What is the primary mechanism by which beta 1 adrenergic receptor activation increases cardiac muscle contraction?

  • Activation of cAMP-dependent protein kinase A (correct)
  • Direct binding to cardiac troponin C
  • Opening of voltage-gated calcium channels
  • Translocation of the receptor to the nucleus

Which of the following is a characteristic of kinase-linked receptors?

  • They directly bind to DNA
  • They are enzyme receptors
  • They activate second messenger systems (correct)
  • They are located in the nucleus

What is the primary role of voltage-gated calcium channels in cardiac muscle cells?

<p>Triggering muscle contraction (B)</p> Signup and view all the answers

Which of the following is a type of receptor discussed in the pharmacodynamics module?

<p>Nuclear receptors (A)</p> Signup and view all the answers

What is the primary function of receptors in cellular communication?

<p>To recognize and transduce chemical signals into cellular responses (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the four main receptor superfamilies?

<p>Steroid hormone receptors (B)</p> Signup and view all the answers

What is the primary mechanism by which ligand-gated ion channels transduce a signal?

<p>They open or close a channel directly in response to ligand binding (A)</p> Signup and view all the answers

How do different receptor types differ in the timescale of their cellular responses?

<p>Ligand-gated ion channels have the fastest responses, on the order of milliseconds (B)</p> Signup and view all the answers

What is the primary role of signal transduction pathways in receptor function?

<p>To link the binding of a ligand to a receptor with the overall cellular response (D)</p> Signup and view all the answers

What is the primary reason that ligand-gated ion channels can produce a very fast response?

<p>They directly open or close the ion channel in response to the drug (D)</p> Signup and view all the answers

Which type of receptor family is considered the largest receptor superfamily?

<p>G-protein coupled receptors (GPCRs) (D)</p> Signup and view all the answers

Which type of receptor family is characterized by a slow response time, typically on the order of hours?

<p>Nuclear receptors (C)</p> Signup and view all the answers

What is the primary mechanism by which G-protein coupled receptors (GPCRs) exert their effects?

<p>They activate intracellular G-proteins (C)</p> Signup and view all the answers

What is the primary reason that tyrosine kinase-linked receptors are considered the most diverse receptor superfamily?

<p>They can be activated by a wide variety of ligands, including proteins, cytokines, and growth factors (A)</p> Signup and view all the answers

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