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Pharmacodynamics: Kinase Linked Receptors

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Pharmacodynamics: Kinase Linked Receptors

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Questions and Answers

Which of the following receptors is involved in regulating cardiac muscle contraction?

Thyroid hormone receptor

Beta 1 adrenergic receptor (correct)

Vitamin D receptor

Estrogen receptor

What is the primary mechanism by which beta 1 adrenergic receptor activation increases cardiac muscle contraction?

Activation of cAMP-dependent protein kinase A (correct)

Direct binding to cardiac troponin C

Opening of voltage-gated calcium channels

Translocation of the receptor to the nucleus

Which of the following is a characteristic of kinase-linked receptors?

They directly bind to DNA

They are enzyme receptors

They activate second messenger systems (correct)

They are located in the nucleus

What is the primary role of voltage-gated calcium channels in cardiac muscle cells?

Triggering muscle contraction Signup and view all the answers

Which of the following is a type of receptor discussed in the pharmacodynamics module?

Nuclear receptors Signup and view all the answers

What is the primary function of receptors in cellular communication?

To recognize and transduce chemical signals into cellular responses Signup and view all the answers

Which of the following is NOT a characteristic of the four main receptor superfamilies?

Steroid hormone receptors Signup and view all the answers

What is the primary mechanism by which ligand-gated ion channels transduce a signal?

They open or close a channel directly in response to ligand binding Signup and view all the answers

How do different receptor types differ in the timescale of their cellular responses?

Ligand-gated ion channels have the fastest responses, on the order of milliseconds Signup and view all the answers

What is the primary role of signal transduction pathways in receptor function?

To link the binding of a ligand to a receptor with the overall cellular response Signup and view all the answers

What is the primary reason that ligand-gated ion channels can produce a very fast response?

They directly open or close the ion channel in response to the drug Signup and view all the answers

Which type of receptor family is considered the largest receptor superfamily?

G-protein coupled receptors (GPCRs) Signup and view all the answers

Which type of receptor family is characterized by a slow response time, typically on the order of hours?

Nuclear receptors Signup and view all the answers

What is the primary mechanism by which G-protein coupled receptors (GPCRs) exert their effects?

They activate intracellular G-proteins Signup and view all the answers

What is the primary reason that tyrosine kinase-linked receptors are considered the most diverse receptor superfamily?

They can be activated by a wide variety of ligands, including proteins, cytokines, and growth factors Signup and view all the answers