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Pharmacodynamics: Enzyme Inhibitors and Receptors

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Pharmacodynamics: Enzyme Inhibitors and Receptors

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Questions and Answers

What type of inhibitor is captopril, which acts on Angiotensin-converting enzyme?

Non-competitive inhibitor

Uncompetitive inhibitor

Competitive inhibitor (correct)

Allosteric inhibitor

Which type of inhibitor binds to an allosteric site separate from the active site of substrate binding?

Uncompetitive inhibitor

Competitive inhibitor

Allosteric inhibitor

Non-competitive inhibitor (correct)

What happens when a competitive inhibitor occupies the active site of an enzyme?

The enzyme is activated

The enzyme-substrate complex is formed

The enzyme-inhibitor complex is formed (correct)

The substrate is converted into product

What are the four protein targets for drug action?

Receptors, Ion channels, Enzymes, Transporters Signup and view all the answers

What is the mechanism of action of a uncompetitive inhibitor?

It binds to the enzyme-substrate complex Signup and view all the answers

What is the result of substrate-binding in uncompetitive inhibition?

A conformational change in the enzyme occurs Signup and view all the answers

What type of inhibition occurs when an inhibitor binds to an enzyme regardless of the presence of a bound substrate?

Noncompetitive inhibition Signup and view all the answers

What is the mechanism of action of the anticancer drug fluorouracil?

It inhibits DNA synthesis by replacing uracil Signup and view all the answers

What is the process by which some drugs require enzymic degradation to become active?

Prodrug activation Signup and view all the answers

What is the effect of Cimetidine on liver microsomal enzymes?

Inhibition Signup and view all the answers

What is the result of enzymic conversion of a drug molecule to a reactive metabolite?

Drug toxicity Signup and view all the answers

What is the role of ATP hydrolysis in ABC transporters?

To provide energy for transport of substances against their electrochemical gradient Signup and view all the answers

What is the role of transporters (carrier molecules) in cellular processes?

Regulation of entry and exit of physiologically important molecules Signup and view all the answers

How do neurotransmitter transporters transport organic molecules?

By exploiting the electrochemical gradient for Na+ Signup and view all the answers

What is the effect of cocaine on Monoamine neurotransmitter uptake?

It blocks the recognition site for neurotransmitter uptake Signup and view all the answers

What is the function of the sodium pump (Na+/K+/ATPase)?

To generate the electrochemical gradient for Na+ Signup and view all the answers

What is the function of multidrug resistance (MDR) transporters?

To eject cytotoxic drugs from cancer cells Signup and view all the answers