18 Questions
What is the mechanism whereby drugs exert their effect on the body?
Pharmacodynamics
Which of the following best describes the difference between drug action and drug effect?
Action precedes effect; effect is the result of action.
Which type of drugs work through physical mechanisms?
Osmotic laxatives
What class of drugs primarily act on biological catalysts in the body?
Enzyme inhibitors
In pharmacology, what remains unchanged at the conclusion of a reaction involving enzymes?
The enzymes
Which type of drugs are relatively or completely specific for certain substrates?
Drugs acting on receptors
When two drugs with the same effect are given together, producing a drug effect that is greater in magnitude than the sum of the individual effects of the two drugs, it is an example of:
Synergism
Which of the following drug combinations results in increased sedation or CNS depression?
Alcohol + Chloral hydrate
Potentiation occurs when:
One drug enhances the effect of another drug without any impact of its own
Which drug combination results in increased hypoglycemic effects?
Alcohol + Chlorpropamide
What type of drug interaction is seen when one drug, lacking an effect of its own, increases the effect of another active drug?
Potentiation
Which drug combination causes increased negative inotropic & chronotropic effects?
Flecainide + Verapamil
Which theory postulates a complementary relationship between the drug molecule and its active site?
Induced-Fit Theory
In receptor theories, what is the function of an antagonist drug?
Counteract an agonist
What attribute of a drug is the measure of the equilibrium constant of the drug-receptor interaction in classical occupation theory?
Affinity
Which type of drug can elicit some but not a maximal effect and antagonize an agonist according to the occupation theory?
Partial Agonist
What is the main requirement for a drug to have its maximum effect according to Clark's Hypothesis?
Both affinity to receptor and occupancy of receptors
Which theory emphasizes that the drug molecule must specifically 'fit into' a receptor to induce a response?
Lock and Key Theory
Learn about the difference between drug action and drug effect in pharmacodynamics, which is the mechanism through which drugs exert their therapeutic effects on the body. Understand how drug action precedes the drug effect and how it alters conditions to bring about the desired effect.
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