Pharmaceutics Terminologies

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Questions and Answers

What is the main difference between transdermal drug delivery and locally acting drugs?

  • Transdermal drug delivery delivers drugs to the systemic circulation, while locally acting drugs act directly on the skin. (correct)
  • Transdermal drug delivery involves diffusion through the skin, while locally acting drugs involve penetration into tissues.
  • Transdermal drug delivery is always regionally acting, while locally acting drugs are never regionally acting.
  • Transdermal drug delivery requires penetration into tissues, while locally acting drugs do not.

Which term describes the chemical species moving into or through the tissue?

  • Diffusion coefficient
  • Permeant (correct)
  • Permeation
  • Diffusivity

In drug delivery, diffusion refers to:

  • Movement of molecules through a domain by random molecular movement. (correct)
  • Movement of molecules from one tissue to another.
  • Movement of molecules from low concentration to high concentration.
  • Movement of molecules from the tissue to the membrane.

What is diffusivity a measure of in drug delivery?

<p>The ability of the permeant to traverse through the tissue. (D)</p> Signup and view all the answers

Regionally acting drugs differ from locally acting drugs in that they:

<p>Do not act directly on the skin or require penetration into tissues. (C)</p> Signup and view all the answers

What defines penetration in drug delivery?

<p>Movement into the tissue without the need to pass out of it. (A)</p> Signup and view all the answers

What is the historical background of topical and transdermal formulations?

<p>Dated back over 2000 years (B)</p> Signup and view all the answers

In England in 2014, how many prescription items were categorized under 'skin'?

<p>Over 40 million (B)</p> Signup and view all the answers

What is the primary use of topical drug delivery?

<p>To treat local disorders (D)</p> Signup and view all the answers

What are some products commonly dispensed alongside treatments for skin conditions?

<p>Emollients and barrier preparations (A)</p> Signup and view all the answers

Which factor does NOT affect the efficacy of topical and transdermal products?

<p>Dosage form color (A)</p> Signup and view all the answers

What percentage of all repeat prescriptions do pharmacists account for in supplying topical and transdermal formulations?

<p>Up to 20% (B)</p> Signup and view all the answers

What does the permeability coefficient (kp) describe?

<p>The speed of permeant transport (C)</p> Signup and view all the answers

Which measure is used to describe the distribution of molecules between two phases?

<p>Partition coefficient (P) (C)</p> Signup and view all the answers

What is the rate of permeant crossing the skin known as?

<p>Flux (J) (B)</p> Signup and view all the answers

Why is skin considered a challenging barrier for drug delivery?

<p>Skin can be damaged by various factors (B)</p> Signup and view all the answers

What does trans-epidermal water loss depend on?

<p>Skin condition (A)</p> Signup and view all the answers

In drug delivery, what does the vehicle refer to?

<p>The formulation in which the drug is applied to the skin (C)</p> Signup and view all the answers

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