10 Questions
What happens to the volume of a suppository during solidification?
It decreases
Why do sodium barbital and salicylic acid crystallize out of polyethylene glycol?
Due to incompatibility
What is the effect of increasing molecular weight on the hygroscopicity of polyethylene glycol bases?
It decreases
What is the purpose of adding 2% aluminium monostearate to a suppository base?
To increase viscosity
Why are cetyl and stearyl alcohols or stearic acid added to suppositories?
To improve consistency
What is the characteristic of cocoa butter suppositories?
Elastic
What is the effect of high concentrations of salicylic acid on polyethylene glycol?
It softens to an ointment-like consistency
Why do synthetic fat bases become brittle?
Due to lack of plasticity
What is the best way to overcome brittleness in suppositories?
Keeping the temperature difference between the melted base and the mould small
Why is penicillin G stable in cocoa butter and other fatty bases?
Due to its incompatibility with polyethylene glycol
Learn about the importance of a suppository's base characteristics, including its ability to release drug components and potential interactions that can affect absorption. Understand how the base can impact the efficacy of the drug and the patient's body. Test your knowledge of this critical aspect of pharmaceuticals!
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