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Pharmaceutical Suppositories: Base Characteristics

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Pharmaceutical Suppositories: Base Characteristics

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Questions and Answers

What happens to the volume of a suppository during solidification?

It becomes inconsistent
It increases
It decreases (correct)
It remains constant

Why do sodium barbital and salicylic acid crystallize out of polyethylene glycol?

Due to high hygroscopicity
Due to low viscosity
Due to incompatibility (correct)
Due to high molecular weight

What is the effect of increasing molecular weight on the hygroscopicity of polyethylene glycol bases?

It decreases (correct)
It increases
It becomes inconsistent
It remains constant

What is the purpose of adding 2% aluminium monostearate to a suppository base?

To increase viscosity (C) Signup and view all the answers

Why are cetyl and stearyl alcohols or stearic acid added to suppositories?

To improve consistency (C) Signup and view all the answers

What is the characteristic of cocoa butter suppositories?

Elastic (A) Signup and view all the answers

What is the effect of high concentrations of salicylic acid on polyethylene glycol?

It softens to an ointment-like consistency (B) Signup and view all the answers

Why do synthetic fat bases become brittle?

Due to lack of plasticity (D) Signup and view all the answers

What is the best way to overcome brittleness in suppositories?

Keeping the temperature difference between the melted base and the mould small (B) Signup and view all the answers

Why is penicillin G stable in cocoa butter and other fatty bases?

Due to its incompatibility with polyethylene glycol (B) Signup and view all the answers