Pharmaceutical Solubility Quiz

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is a common method used to improve the aqueous solubility of active agents?

Complexation with polyvinylpyrrolidone (correct)

Using non-aqueous solvents

Chemical modification

Converting to a crystalline form

Which of the following drug modifications can produce a water-soluble derivative?

Polymer encapsulation

Addition of emulsifiers

Synthesis of esters

Synthesis of sodium phosphate salts (correct)

Why might non-aqueous solvents be preferable for certain drug formulations?

They are always cheaper than aqueous solvents

They can be used when drugs are unstable in aqueous systems (correct)

They increase the stability of all drugs

They provide better flavor and taste

Which oil mentioned is suitable for parenteral use?

Almond oil Signup and view all the answers

What characteristic of fixed oils must be considered for parenteral solutions?

They are non-volatile Signup and view all the answers

How does the pH of a solution affect the solubility of a weak acid?

Increased pH improves solubility. Signup and view all the answers

What is a key consideration when determining the pH for drug solubility?

It should ensure compatibility with other ingredients. Signup and view all the answers

What type of agent can improve the solubility of poorly soluble drugs?

Surface-active agents Signup and view all the answers

What phenomenon is utilized for the formulation of solutions of poorly soluble drugs?

Micellar solubilization Signup and view all the answers

What should be avoided when using surfactants for drug solubilization?

Adding excessive amounts of surfactants. Signup and view all the answers

Which of the following describes the characteristic of water as a solvent in pharmaceutical products?

Water has a high dielectric constant, which helps in dissolving ionisable materials. Signup and view all the answers

What is the primary reason why purified water must be used when salts are undesirable?

Purified Water is freshly boiled, eliminating unwanted microorganisms. Signup and view all the answers

Which type of water is essential for formulating parenteral solutions?

Water for Injections Signup and view all the answers

What is a significant drawback of using aqueous solutions in pharmaceuticals?

They can support the growth of microorganisms. Signup and view all the answers

For drugs sensitive to carbon dioxide, which type of water should be used?

Water for Injections free from carbon dioxide Signup and view all the answers

Study Notes

Dosage Forms I (PT303)

Course: Dosage Forms I
Faculty: Faculty of Pharmacy
Department: Department of Pharmaceutics & Industrial Pharmacy
University: Suez Canal University
Year: Second Year Students
Academic Year: 2021/2022

Liquid Dosage Forms

Understanding solution properties, solubility factors, and dissolution is crucial in pharmaceutical formulation.
Generally, the solvent is the major component, although exceptions exist (e.g., syrup).
Advantages of liquid dosage forms: easier to swallow for pediatric/geriatric patients; quicker drug absorption; uniform drug distribution; reduced gastric irritation compared to solid dosage forms.
Disadvantages of liquid dosage forms: bulky and inconvenient to store and transport; less stable than solid forms; risk of microbial growth; precise dosage can be challenging.

Choice of Solvent

Water is the most common solvent due to its physiological compatibility and high dielectric constant, suitable for ionisable materials.
Purified Water (freshly boiled and cooled) is used where salt content is undesirable.
Water for Injections is used for parenteral solutions, treated to remove pyrogens.

Approaches to Increasing Solubility

Cosolvency: using a combination of solvents to improve the solubility of a drug in water.
pH control: adjusting pH to enhance the solubility of weak acids or bases.
Solubilization: using surface-active agents (SAAs) to increase the solubility of poorly soluble drugs. Micelles can encapsulate the hydrophobic portion of a substance. This allows the substances to dissolve.
Complexation: forming a complex between a poorly soluble drug and a soluble material to increase solubility.
Chemical modification: converting a drug to a more water-soluble form, such as by the formation of salts.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

Test your knowledge on the principles of drug solubility and formulation. This quiz covers various methods to enhance aqueous solubility, the role of pH, and considerations for parenteral applications. Ideal for students and professionals in pharmacology and pharmaceutical sciences.