Pharmaceutical Organic Chemistry 2024-2025
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Questions and Answers

What is referred to as the limiting reactant in a chemical reaction?

  • The reactant that produces the least amount of product (correct)
  • The reactant that is present in excess
  • The reactant that is completely consumed first (correct)
  • The reactant that determines the theoretical yield

Which yield percentage classification indicates a reaction that is still acceptable but not ideal?

  • Fair (correct)
  • Very good
  • Excellent
  • Quantitative

How is atom economy calculated for a chemical reaction?

  • By dividing the mass of the reactants by the mass of the desired product
  • By dividing the total number of atoms in the desired product by the total number of atoms in all reactants (correct)
  • By multiplying the theoretical yield by the actual yield
  • By summing all atoms in reactants and subtracting products

Why is a high atom economy preferred in chemical reactions?

<p>It indicates less waste and higher efficiency (D)</p> Signup and view all the answers

Which of the following statements regarding theoretical yield is correct?

<p>Theoretical yield is calculated based on the limiting reactant (B)</p> Signup and view all the answers

Which acylating agent has the highest atom economy and is considered the best for aspirin synthesis?

<p>Glacial acetic acid (D)</p> Signup and view all the answers

What is the reaction efficiency when reacting acetic acid and ethanol to produce ethyl acetate given a % yield of 80%?

<p>62.66% (A)</p> Signup and view all the answers

In the reaction to produce ethyl acetate, what is the theoretical yield in grams when acetic acid is the limiting reactant?

<p>88 g (A)</p> Signup and view all the answers

Which of the following statements correctly encapsulates the goal of green chemistry?

<p>To design synthetic pathways that enhance atom economy and yield. (A)</p> Signup and view all the answers

What is the calculated atom economy of acetic acid anhydride?

<p>78.74% (B)</p> Signup and view all the answers

Flashcards

Atom Economy

A measure of the efficiency of a chemical reaction in terms of how many reactant atoms are incorporated into the desired product.

Acetyl Chloride

A chemical compound used as a reagent in organic chemistry to introduce an acetyl group (CH3CO-) into a molecule.

Acetic Acid Anhydride

An organic compound used as a reagent in organic chemistry to introduce acetyl groups.

Glacial Acetic Acid

Pure acetic acid, often solid at room temperature, and used as a reagent in organic chemistry.

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% Atom Economy

A percentage value calculated to measure the efficiency of incorporating reactant atoms into the desired product.

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Reaction Efficiency

A measure of reaction success calculated by multiplying % yield and % atom economy.

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Limiting Reactant

The reactant that gets completely used up in a reaction, thus determining the maximum amount of product that can be formed.

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Theoretical Yield

The maximum amount of product that can be obtained from a reaction based on the stoichiometry (mole ratios) and the limiting reactant.

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Reactant Yield

The amount of product obtained in a chemical reaction

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Actual Yield

The actual mass of product made in a chemical reaction

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Theoretical Yield

The maximum amount of product that can be made from a reaction assuming all the limiting reactant is used up.

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Limiting Reactant

The reactant that is consumed completely first in a chemical reaction, thus limiting the amount of product that can be formed.

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Yield Percentage

Ratio of actual yield to theoretical yield, represented as a percentage.

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Atom Economy

A measure of the efficiency of a chemical reaction in terms of how many atoms of the desired product are formed compared to all atoms in the reactants.

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Quantitative Yield

Reaction yield close to or equal to 100%

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Excellent Yield

Reaction yield above 90%

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Very Good Yield

Reaction yield above 80%

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Good Yield

Reaction yield between 70-60%

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Study Notes

Pharmaceutical Organic Chemistry 2024-2025

  • Course covers calculation of yield of reactions, atom economy, and practical work.

Calculation of Yield of Reaction

  • Yield: The amount of product obtained in a chemical reaction.
  • Actual yield: The measured amount of product.
  • Theoretical yield: The maximum amount of product that can be obtained from the complete conversion of the limiting reagent.
  • Limiting reagent (reactant): The reactant with the fewest moles, which limits the reaction.
  • Ideal/Theoretical Yield: 100%

Calculation of Yield of Reaction

  • Yield Percentage (relative yield): Measures the effectiveness of a synthesis.
  • Theoretical Yield Calculation: no. of moles of limiting factor x molecular wt of product.
  • Yield Percentage Calculation: (Actual yield / Theoretical yield) x 100%

Classifying Reaction Yields

  • Quantitative: Yields around 100%.
  • Excellent: Yields above 90%.
  • Very Good: Yields above 80%.
  • Good: Yields above 70-60%.
  • Fair: Yields below 50%.
  • Poor: Yields below 40%.

Atom Economy

  • Definition: A measure of the efficiency of a chemical reaction. It's calculated by dividing the total number of atoms in the desired product by the total number of atoms in all reactants.
  • Calculation: (Mass of Product / Mass of Reactants) x 100%
  • Importance: Helps choose the most efficient reactions, reducing waste and maximizing desired product. If two reactions produce the same product, the one with higher atom economy is more efficient.

Atom Economy in Aspirin Synthesis

  • Different acylating agents (acetyl chloride, acetic anhydride, acetic acid) have different atom economies for aspirin synthesis.
  • Acetic acid has the highest atom economy (95.47%).

Reaction Efficiency

  • Definition: Measures the mass of reactant atoms in the final product.
  • Calculation: % yield x atom economy
  • Green chemistry goal: Design synthetic pathways that improve both atom economy and yield to minimize waste.

Example 1: Ethyl Acetate Synthesis

  • Reactants: 120 g of acetic acid and 230 g of ethanol.
  • Product: 132 g of ethyl acetate.
  • Calculations: Include steps to calculate molecular weights, moles, limiting reagent, theoretical yield, yield %, and reaction efficiency.

Practical Work: Liberation of Acid from Salt (Sodium Benzoate)

  • Reaction: Sodium benzoate + HCl → Benzoic acid + NaCl
  • Purpose: Demonstrates the liberation of benzoic acid from its salt form. Used as an antifungal preservative and test for liver function.
  • Procedure:
    1. Dissolve sodium benzoate in water.
    2. Add HCl dropwise until precipitation occurs.
    3. Filter the precipitate.
    4. Recrystallize the benzoic acid.
  • Materials: 1 g of sodium benzoate, 5 mL of water, 2.5 mL of 3N HCl, small beakers, filtration apparatus, and hot water.

Tools

  • 2 small beakers
  • Conical flask
  • Watch glass
  • Funnel
  • 2 filter papers
  • Dropper
  • Lab coat
  • Eye goggles
  • Towel
  • Holder

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Description

This quiz covers the calculation of yields in organic chemistry reactions, including actual yield, theoretical yield, and the concept of limiting reagents. Test your understanding of yield percentages and their classification. Perfect for students in a pharmaceutical organic chemistry course.

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