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Questions and Answers
What is the mechanism of action of ethylene oxide in sterilization?
What is the mechanism of action of ethylene oxide in sterilization?
What is the capacity of a gas autoclave used for ethylene oxide sterilization?
What is the capacity of a gas autoclave used for ethylene oxide sterilization?
Which factor affects the efficacy of ethylene oxide sterilization?
Which factor affects the efficacy of ethylene oxide sterilization?
What is the temperature range for effective ethylene oxide sterilization?
What is the temperature range for effective ethylene oxide sterilization?
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Which material does ethylene oxide penetrate during sterilization?
Which material does ethylene oxide penetrate during sterilization?
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Study Notes
Mechanism of Action of Ethylene Oxide
- Alkylating agent that denatures proteins and disrupts DNA, preventing microorganisms from reproducing
- Reacts with amino, hydroxyl, and sulfhydryl groups in proteins and nucleic acids, rendering them inactive
Ethylene Oxide Sterilization
Capacity of Gas Autoclave
- Typically ranges from 100 to 10,000 liters, depending on the size of the items to be sterilized
Factors Affecting Efficacy of Ethylene Oxide Sterilization
- Temperature
- Humidity
- Concentration of ethylene oxide
- Exposure time
- Type and quantity of microorganisms present
- Presence of organic matter or moisture
Temperature Range for Effective Ethylene Oxide Sterilization
- 49°C to 63°C (120°F to 145°F)
Material Penetration
- Ethylene oxide penetrates:
- Plastics
- Rubber
- Fabric
- And other porous materials
- Allows for sterilization of heat-sensitive materials
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Description
Test your knowledge of cold sterilization methods in pharmaceutical microbiology with this quiz. Learn about gas sterilization, radiation, and filtration techniques commonly used in the industry.
