30 Questions
What is the estimated annual loss of exclusivity for the pharmaceutical industry from 2008 to 2011?
$11 Bn
What is the perception problem faced by Brand Pharma?
The Big Evil Pharma
Which industry has the highest R&D percentage of sales?
Research-based Pharmaceuticals
What is the pressure faced by the pharmaceutical industry due to healthcare reforms?
Further payor pressure
What is the challenge faced by the pharmaceutical industry due to patent expiries?
Loss of exclusivity
What percentage of sales do Research-based Pharmaceuticals spend on R&D?
17.5%
What was the most significant discovery of the 20th century in the context of drug development?
The Randomised, Double Blind, Placebo Controlled Clinical Trial
What is the cumulative success rate of the Pre-Clinical Phase in the 2000-2003 period?
68.23%
What is the average development timeframe in years in the 2010s?
4.3
What was the outcome of the drug amendments in the USA in the 1960s?
The establishment of the FDA
What is the main challenge for Pharma innovation according to the Bain Consulting Drug Development Attrition Model?
All of the above
What was the outcome of the enactment of the SAPHRA act in 2017?
The modernisation of clinical trials in South Africa
How many total developments from first-time in man (FIM) to FDA registration has South Africa achieved?
3
What is the primary reason for the decline in Pharma innovation?
Increasing payor pressures and shorter exclusivity periods
What is the last anti-TB drug registered in South Africa?
Rifapentine
What was the outcome of Pfizer's $900 million investment in testing its HDL increasing drug, torcetrapib?
The drug failed in Phase III
What is the name of the device that is currently being developed in South Africa?
BURL- device
What is one of the FDA's six priority public health challenges in 2004?
Developing antibiotics and countermeasures to combat emerging infections and bioterrorism
What is one of the benefits of using innovative study designs in clinical trials?
Optimal designs of trial protocols
What is a key aspect of the creative process delivery in clinical trials?
Electronic data capturing
What is one of the areas where South Africa has a competitive edge?
Primate research
What is required for research clinicians?
All of the above
What is a key benefit of a drug development-friendly regulatory authority?
28-day CTA-exemption
What can individuals do to support clinical research at the UP Medical school?
Create a research culture
What was the outcome of the 15,000-patient study on torcetrapib in December 2006?
It revealed that the chemical increased death rates
What is the main goal of personalised medicine?
To increase the efficacy of drugs while reducing adverse events
According to the source, how much can the cost of drug development be reduced with the help of pharmacogenomics?
$1.3 billion to $200 million
What is the potential benefit of using biomarkers in drug development?
Early elimination of unviable/unsafe candidates
What is the main advantage of predictive bio-simulation in drug development?
It can replace distant clinical endpoints with more proximal surrogate endpoints
What is the estimated time-to-market for a new drug with the help of pharmacogenomics?
2-4 years
Test your knowledge on the current challenges facing the pharmaceutical industry, including patent expiries, payor pressure, and growing safety concerns. Learn about the impact of exclusivity loss and generic competition from emerging markets.
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