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What is the term used to refer to interactions between two or more substances which leads to changes in physical, chemical, and therapeutic properties of pharmaceutical dosage forms?
What is the term used to refer to interactions between two or more substances which leads to changes in physical, chemical, and therapeutic properties of pharmaceutical dosage forms?
What is the common outcome of incompatibility when chalk powder is added to a small amount of water (e.g., 2ml)?
What is the common outcome of incompatibility when chalk powder is added to a small amount of water (e.g., 2ml)?
Which factor may affect the solubility of the prescribed agent in the vehicle and render it less soluble?
Which factor may affect the solubility of the prescribed agent in the vehicle and render it less soluble?
What is an example of a common diffusible solid that may provide precipitation when added with water?
What is an example of a common diffusible solid that may provide precipitation when added with water?
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Which dosage form is commonly associated with physical incompatibility due to immiscibility?
Which dosage form is commonly associated with physical incompatibility due to immiscibility?
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Physical and chemical incompatibility refers to interactions between two or more substances which leads to changes in physical, chemical, therapeutic properties of pharmaceutical dosage forms. Usually changes can be seen when mixing two or more substances. It may affect the safety, efficacy, appearance of pharmaceutical dosage form. Incompatibilities occur at: Compounding, Formulation, Manufacturing, Packaging, Dispensing, Storage, Administration of Drugs.
Physical and chemical incompatibility refers to interactions between two or more substances which leads to changes in physical, chemical, therapeutic properties of pharmaceutical dosage forms. Usually changes can be seen when mixing two or more substances. It may affect the safety, efficacy, appearance of pharmaceutical dosage form. Incompatibilities occur at: Compounding, Formulation, Manufacturing, Packaging, Dispensing, Storage, Administration of Drugs.
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___ occur at: Compounding, Formulation, Manufacturing, Packaging, Dispensing, Storage, Administration of Drugs.
___ occur at: Compounding, Formulation, Manufacturing, Packaging, Dispensing, Storage, Administration of Drugs.
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Examples of Common Diffusible ______: Chalk, Acetylsalicylic Acid, Succinyl, Sulfathiazole, Zinc oxide, Calamine, Resins, Tinctures or Chlorophyl – can provide precipitation when added with water. Example of Insolubility Prescription Rx Chalk Powder – 2g Tinture catechu – 2ml Cinnamon water – 2ml + 30ml This prescription has insolubility because water is in small amount (2ml) which should be added with any amount of water (ex: 30ml) as long as it is not lower to the prescribed agent (chalk powder) There will be more precipitation when chalk powder is added to small amount of water (2ml) Add any suspending agent that will prevent the precipitation of chalk powder. Suspending agent example: Tragacanth These always have insoluble issues: antibiotics (suspensions), corticosteroids, sulfurs, resins, tinctures.
Examples of Common Diffusible ______: Chalk, Acetylsalicylic Acid, Succinyl, Sulfathiazole, Zinc oxide, Calamine, Resins, Tinctures or Chlorophyl – can provide precipitation when added with water. Example of Insolubility Prescription Rx Chalk Powder – 2g Tinture catechu – 2ml Cinnamon water – 2ml + 30ml This prescription has insolubility because water is in small amount (2ml) which should be added with any amount of water (ex: 30ml) as long as it is not lower to the prescribed agent (chalk powder) There will be more precipitation when chalk powder is added to small amount of water (2ml) Add any suspending agent that will prevent the precipitation of chalk powder. Suspending agent example: Tragacanth These always have insoluble issues: antibiotics (suspensions), corticosteroids, sulfurs, resins, tinctures.
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It means the inability of material to dissolve in a particular solvent system. The following factors affect the solubility of the prescribed agent in the vehicle and may render it less soluble Change in pH Milling Surfactant Chemical reaction Complex formation Change in pH, Milling, Surfactant, Chemical reaction, Complex formation – these may affect the solubility of the prescribed agent.
It means the inability of material to dissolve in a particular solvent system. The following factors affect the solubility of the prescribed agent in the vehicle and may render it less soluble Change in pH Milling Surfactant Chemical reaction Complex formation Change in pH, Milling, Surfactant, Chemical reaction, Complex formation – these may affect the solubility of the prescribed agent.
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___ It means the inability of material to dissolve in a particular solvent system.
___ It means the inability of material to dissolve in a particular solvent system.
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Study Notes
Incompatibility in Pharmaceutical Dosage Forms
- Interactions between substances can cause changes in physical, chemical, and therapeutic properties.
- Incompatibility can compromise safety, efficacy, and appearance of pharmaceutical products.
- Incompatibilities may manifest at various stages: Compounding, Formulation, Manufacturing, Packaging, Dispensing, Storage, and Administration of Drugs.
Effects of Chalk Powder in Water
- When 2g of chalk powder is added to 2ml of water, significant precipitation occurs.
- Increasing the volume of water beyond 2ml is necessary to minimize precipitation and enhance solubility.
Factors Affecting Solubility
- Several factors influence the solubility of a substance in its vehicle, including:
- Change in pH
- Milling process
- Addition of surfactants
- Occurrence of chemical reactions
- Formation of complexes
Examples of Common Diffusible Solids
- Substances like chalk, acetylsalicylic acid, succinyl, sulfathiazole, zinc oxide, calamine, resins, and tinctures can precipitate when mixed with water.
Physical Incompatibility with Dosage Forms
- Commonly associated with dosage forms that exhibit immiscibility, such as suspensions and certain emulsions.
- Suspended drugs frequently include antibiotics, corticosteroids, and resins, which may have solubility challenges.
Use of Suspending Agents
- To prevent precipitation, suspending agents like tragacanth can be added to enhance the stability of mixtures containing insoluble components.
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Test your knowledge on physico-chemical and therapeutical incompatibility in pharmaceutical dosage forms. Explore the impact of mixing substances on safety, efficacy, and appearance within various stages of drug production and administration.
