Podcast
Questions and Answers
Pharmaceutical formulationPharmaceutics CH4417 Lecture 3 Dr Sarah Hudson [email protected] MS2-019, Dept. of Chemical Sciences, SSPC, Bernal Institute Active Pharmaceutical Ingredients Small Molecule versus large Biomolecules They differ in terms of the following (but it is API dependent): Primary Manufacturing Secondary Manufacturing Dosage Forms Routes of administration Cost Generics/Biosimilars Manufacturing Processes Manufacturing of Small Molecule Active Pharmaceutical Ingredients expensive products and raw materials yield and purity most important small productions often batch processes often agitated tanks – 1 – 10 m3 multipurpose, multiproduct plants flexibility quick process development batch integrity tradition Production campaigns ≥10 days Value of one batch. Cleaning Increasing interest into continuous manufacturing systems. InTech-Anaerobic treatment of industrial effluents an overview of applications Common Unit Operations Filtration Mixing Solvent Extraction Distillation Centrifugation Grinding pH adjustment Washing Carbon treatment (adsorption) Crystallization/precipitation Drying Continuous Manufacturing https://www.lilly.com/our-medicines/manufacturing-quality/for-better-lives Sau Lee. J. Pharm Innov (2015) 10:191-199.
Pharmaceutical formulationPharmaceutics CH4417 Lecture 3 Dr Sarah Hudson [email protected] MS2-019, Dept. of Chemical Sciences, SSPC, Bernal Institute Active Pharmaceutical Ingredients Small Molecule versus large Biomolecules They differ in terms of the following (but it is API dependent): Primary Manufacturing Secondary Manufacturing Dosage Forms Routes of administration Cost Generics/Biosimilars Manufacturing Processes Manufacturing of Small Molecule Active Pharmaceutical Ingredients expensive products and raw materials yield and purity most important small productions often batch processes often agitated tanks – 1 – 10 m3 multipurpose, multiproduct plants flexibility quick process development batch integrity tradition Production campaigns ≥10 days Value of one batch. Cleaning Increasing interest into continuous manufacturing systems. InTech-Anaerobic treatment of industrial effluents an overview of applications Common Unit Operations Filtration Mixing Solvent Extraction Distillation Centrifugation Grinding pH adjustment Washing Carbon treatment (adsorption) Crystallization/precipitation Drying Continuous Manufacturing https://www.lilly.com/our-medicines/manufacturing-quality/for-better-lives Sau Lee. J. Pharm Innov (2015) 10:191-199.
