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Pharmaceutical Fillers

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Questions and Answers

What is the primary function of fillers in the preparation of dosage forms?

To facilitate precise metering and handling of the drug substance (correct)

To add color to the dosage form

To enhance the bioavailability of the drug

To provide a pleasant taste to the dosage form

What is a characteristic of a good filler?

It should be expensive and compatible with only a few excipients

It should be highly reactive

It should be highly hygroscopic

It should be inert and non-hygroscopic (correct)

What is the primary function of binders in tablet formulation?

To enhance the flowability of the powder

To add color to the tablet

To hold the ingredients in a tablet together (correct)

To improve the dissolution rate of the drug

What type of binder is dissolved in a solvent, such as water or alcohol, during a wet granulation process?

Solution binder Signup and view all the answers

Which of the following is NOT a typical feature of a binder?

Enhancement of drug bioavailability Signup and view all the answers

Which of the following is an example of a dry binder?

Cellulose derivatives added to the powder blend Signup and view all the answers

What is the primary function of disintegrants in pharmaceutical formulations?

To enhance the dissolution of tablets or capsules Signup and view all the answers

Which of the following is an ideal property of a disintegrant?

Good hydration capacity Signup and view all the answers

What is the primary function of coating agents in pharmaceutical formulations?

To provide a protective coating to the dosage form Signup and view all the answers

What type of sorbent is peat moss?

Natural sorbent Signup and view all the answers

What is the function of sorbents in pharmaceutical formulations?

To limit fluid sorbing in a dry state Signup and view all the answers

What is an example of a coating agent used in pharmaceutical formulations?

HPMC Signup and view all the answers

What is the primary function of antiadherents in tablet manufacturing?

To prevent sticking of tablets to the die walls and punches Signup and view all the answers

Which type of lubricant is most widely used in tablet manufacturing today?

Hydrophobic lubricant Signup and view all the answers

What is the role of hydrophobic lubricants in tablet manufacturing?

To facilitate tablet ejection with low friction Signup and view all the answers

What is the typical concentration at which hydrophobic lubricants are effective?

Relatively low concentrations Signup and view all the answers

Which of the following is an example of a hydrophobic lubricant?

Magnesium stearate Signup and view all the answers

What is the primary role of a true lubricant in tablet manufacturing?

To decrease friction at the interface between the tablet surface and the die wall Signup and view all the answers