Pharmaceutical Fillers

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Questions and Answers

What is the primary function of fillers in the preparation of dosage forms?

  • To facilitate precise metering and handling of the drug substance (correct)
  • To add color to the dosage form
  • To enhance the bioavailability of the drug
  • To provide a pleasant taste to the dosage form

What is a characteristic of a good filler?

  • It should be expensive and compatible with only a few excipients
  • It should be highly reactive
  • It should be highly hygroscopic
  • It should be inert and non-hygroscopic (correct)

What is the primary function of binders in tablet formulation?

  • To enhance the flowability of the powder
  • To add color to the tablet
  • To hold the ingredients in a tablet together (correct)
  • To improve the dissolution rate of the drug

What type of binder is dissolved in a solvent, such as water or alcohol, during a wet granulation process?

<p>Solution binder (B)</p> Signup and view all the answers

Which of the following is NOT a typical feature of a binder?

<p>Enhancement of drug bioavailability (A)</p> Signup and view all the answers

Which of the following is an example of a dry binder?

<p>Cellulose derivatives added to the powder blend (A)</p> Signup and view all the answers

What is the primary function of disintegrants in pharmaceutical formulations?

<p>To enhance the dissolution of tablets or capsules (A)</p> Signup and view all the answers

Which of the following is an ideal property of a disintegrant?

<p>Good hydration capacity (D)</p> Signup and view all the answers

What is the primary function of coating agents in pharmaceutical formulations?

<p>To provide a protective coating to the dosage form (B)</p> Signup and view all the answers

What type of sorbent is peat moss?

<p>Natural sorbent (A)</p> Signup and view all the answers

What is the function of sorbents in pharmaceutical formulations?

<p>To limit fluid sorbing in a dry state (D)</p> Signup and view all the answers

What is an example of a coating agent used in pharmaceutical formulations?

<p>HPMC (B)</p> Signup and view all the answers

What is the primary function of antiadherents in tablet manufacturing?

<p>To prevent sticking of tablets to the die walls and punches (B)</p> Signup and view all the answers

Which type of lubricant is most widely used in tablet manufacturing today?

<p>Hydrophobic lubricant (B)</p> Signup and view all the answers

What is the role of hydrophobic lubricants in tablet manufacturing?

<p>To facilitate tablet ejection with low friction (D)</p> Signup and view all the answers

What is the typical concentration at which hydrophobic lubricants are effective?

<p>Relatively low concentrations (A)</p> Signup and view all the answers

Which of the following is an example of a hydrophobic lubricant?

<p>Magnesium stearate (B)</p> Signup and view all the answers

What is the primary role of a true lubricant in tablet manufacturing?

<p>To decrease friction at the interface between the tablet surface and the die wall (B)</p> Signup and view all the answers

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