18 Questions
What is the primary function of fillers in the preparation of dosage forms?
To facilitate precise metering and handling of the drug substance
What is a characteristic of a good filler?
It should be inert and non-hygroscopic
What is the primary function of binders in tablet formulation?
To hold the ingredients in a tablet together
What type of binder is dissolved in a solvent, such as water or alcohol, during a wet granulation process?
Solution binder
Which of the following is NOT a typical feature of a binder?
Enhancement of drug bioavailability
Which of the following is an example of a dry binder?
Cellulose derivatives added to the powder blend
What is the primary function of disintegrants in pharmaceutical formulations?
To enhance the dissolution of tablets or capsules
Which of the following is an ideal property of a disintegrant?
Good hydration capacity
What is the primary function of coating agents in pharmaceutical formulations?
To provide a protective coating to the dosage form
What type of sorbent is peat moss?
Natural sorbent
What is the function of sorbents in pharmaceutical formulations?
To limit fluid sorbing in a dry state
What is an example of a coating agent used in pharmaceutical formulations?
HPMC
What is the primary function of antiadherents in tablet manufacturing?
To prevent sticking of tablets to the die walls and punches
Which type of lubricant is most widely used in tablet manufacturing today?
Hydrophobic lubricant
What is the role of hydrophobic lubricants in tablet manufacturing?
To facilitate tablet ejection with low friction
What is the typical concentration at which hydrophobic lubricants are effective?
Relatively low concentrations
Which of the following is an example of a hydrophobic lubricant?
Magnesium stearate
What is the primary role of a true lubricant in tablet manufacturing?
To decrease friction at the interface between the tablet surface and the die wall
Learn about the role of fillers in pharmaceuticals, their typical features, and common examples. Test your knowledge of fillers in tablets and capsules.
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