Podcast
Questions and Answers
Dry granulation is the process of powder granulation by compression without using ______ or solvent.
Dry granulation is the process of powder granulation by compression without using ______ or solvent.
heat
The principle of dry granulation is summarized by forming a compact of the material by slight compression followed by ______ of the compact.
The principle of dry granulation is summarized by forming a compact of the material by slight compression followed by ______ of the compact.
milling
The method used for dry granulation includes slugging technique and ______ compaction technique.
The method used for dry granulation includes slugging technique and ______ compaction technique.
roller
In the slugging method, the resulting tablets called slugs are then ______ to yield granules.
In the slugging method, the resulting tablets called slugs are then ______ to yield granules.
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A slug is a large flat tablet that contains half the amount of ______ to enhance powder flow during slugging.
A slug is a large flat tablet that contains half the amount of ______ to enhance powder flow during slugging.
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In the roller compaction method, two rolls rotate against each other to increase the ______ of powder.
In the roller compaction method, two rolls rotate against each other to increase the ______ of powder.
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One advantage of dry granulation is that it requires less ______ and space compared to wet granulation.
One advantage of dry granulation is that it requires less ______ and space compared to wet granulation.
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Dry granulation is especially useful for heat and/or moisture sensitive ______.
Dry granulation is especially useful for heat and/or moisture sensitive ______.
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Dry granulation ensures uniform distribution of active ingredients, preventing ______ of particles.
Dry granulation ensures uniform distribution of active ingredients, preventing ______ of particles.
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The binder used in dry granulation method is in powder form, leading to rapid ______ compared to wet granulation.
The binder used in dry granulation method is in powder form, leading to rapid ______ compared to wet granulation.
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Study Notes
Dry Granulation
- Dry granulation is a powder granulation method using compression without heat or solvents.
- This technique is used when drugs can't be directly compressed (e.g., high dose, flowability issues) and are heat/moisture sensitive.
- Cohesive properties of the active ingredient or diluent are essential.
Methods of Dry Granulation
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Slugging Technique:
- Ingredients are weighed and mixed.
- The powder mixture is compressed (slugged) into large tablets (slugs).
- Slugs are then milled into granules.
- Slugs are large, flat tablets or pellets, approximately one inch in diameter.
- Half the typical lubricant amount is added during slugging to improve flow and prevent sticking to the die.
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Roller Compaction Technique:
- Two rotating rollers increase powder density by pressing it.
- This creates a thin sheet or ribbon, similar to a slug.
- The sheet is screened to produce uniform granules.
- This method handles large amounts of material rapidly.
Advantages of Dry Granulation
- Requires less equipment and space than wet granulation.
- Suitable for heat/moisture-sensitive drugs (e.g., effervescent tablets).
- Rapid disintegration due to the use of powder binder, resulting in a faster disintegration rate.
- Improves dissolution for anhydrous, soluble compounds.
- Ensures uniform distribution of active ingredients (prevents segregation).
Disadvantages of Dry Granulation
- Requires specialized equipment for granule production.
- Dust generation from the dry process can lead to cross-contamination.
- Dissolution issues can occur for insoluble drugs.
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Description
Explore the techniques of dry granulation used in pharmaceuticals, including slugging and roller compaction. Learn how these methods are essential for handling heat or moisture-sensitive drugs and ensuring proper granule formation.
