Pharmaceutical Compounding: Factors and Prevention of Polymerization

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Which of the following can induce polymerization in a pharmaceutical formulation?

Suitable vehicle selection

Light exposure (correct)

Isomerization

pH adjustment

What is the primary purpose of using buffers in pharmaceutical compounding?

To prevent chemical incompatibility reactions

To reduce the risk of isomerization

To absorb light and prevent polymerization

To maintain the optimal pH for drug stability (correct)

What is the benefit of storing pharmaceutical ingredients at a suitable low temperature?

To promote isomerization

To prevent polymerization of ingredients (correct)

To prevent chemical incompatibility reactions

To maintain the optimal pH

Which of the following can be used to prevent polymerization in pharmaceutical compounding?

Suitable vehicle selection (D) Signup and view all the answers

What is the primary concern when combining surfactants with different charges in a pharmaceutical formulation?

Chemical incompatibility reactions (A) Signup and view all the answers

What is the term for the conversion of a drug to its isomer?

Isomerization (B) Signup and view all the answers

What is the primary reason for using hydroalcoholic or alcoholic vehicles in pharmaceutical formulation?

To prevent oxidation of the drug ingredients (D) Signup and view all the answers

What is the primary function of buffers in pharmaceutical formulation?

To adjust the pH of the formulation (C) Signup and view all the answers

Why is it necessary to protect the drug formulation from light?

To prevent degradation of the active ingredients (B) Signup and view all the answers

What is the benefit of selecting a solid dosage form over a solution?

Reduced risk of oxidation of the drug ingredients (D) Signup and view all the answers

Why is it important to store pharmaceutical formulations at a low temperature?

To prevent oxidation and degradation of the drug ingredients (B) Signup and view all the answers

What is the purpose of replacing oxygen with nitrogen inside the container?

To prevent oxidation of the drug ingredients (A) Signup and view all the answers

What is the purpose of adding a thickening agent in liquid preparations containing indiffusible solids?

To obtain an elegant product with uniform dose (B) Signup and view all the answers

Why are wetting agents used in formulations containing insoluble powders?

To enhance the wetting of the powders (C) Signup and view all the answers

What is the consequence of using excess surface active agents in a formulation?

Claying due to deflocculation (D) Signup and view all the answers

How can the insolubility of potent drugs be addressed?

By converting them into salt forms (C) Signup and view all the answers

What happens when a resinous tincture is added to water?

The resin agglomerates forming indiffusible clots (B) Signup and view all the answers

What is the purpose of using polysorbates in parenteral suspensions of corticosteroids and antibiotics?

To act as a wetting agent and prevent claying (B) Signup and view all the answers