Pharmaceutical Compounding: Factors and Prevention of Polymerization

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Questions and Answers

Which of the following can induce polymerization in a pharmaceutical formulation?

  • Suitable vehicle selection
  • Light exposure (correct)
  • Isomerization
  • pH adjustment

What is the primary purpose of using buffers in pharmaceutical compounding?

  • To prevent chemical incompatibility reactions
  • To reduce the risk of isomerization
  • To absorb light and prevent polymerization
  • To maintain the optimal pH for drug stability (correct)

What is the benefit of storing pharmaceutical ingredients at a suitable low temperature?

  • To promote isomerization
  • To prevent polymerization of ingredients (correct)
  • To prevent chemical incompatibility reactions
  • To maintain the optimal pH

Which of the following can be used to prevent polymerization in pharmaceutical compounding?

<p>Suitable vehicle selection (D)</p> Signup and view all the answers

What is the primary concern when combining surfactants with different charges in a pharmaceutical formulation?

<p>Chemical incompatibility reactions (A)</p> Signup and view all the answers

What is the term for the conversion of a drug to its isomer?

<p>Isomerization (B)</p> Signup and view all the answers

What is the primary reason for using hydroalcoholic or alcoholic vehicles in pharmaceutical formulation?

<p>To prevent oxidation of the drug ingredients (D)</p> Signup and view all the answers

What is the primary function of buffers in pharmaceutical formulation?

<p>To adjust the pH of the formulation (C)</p> Signup and view all the answers

Why is it necessary to protect the drug formulation from light?

<p>To prevent degradation of the active ingredients (B)</p> Signup and view all the answers

What is the benefit of selecting a solid dosage form over a solution?

<p>Reduced risk of oxidation of the drug ingredients (D)</p> Signup and view all the answers

Why is it important to store pharmaceutical formulations at a low temperature?

<p>To prevent oxidation and degradation of the drug ingredients (B)</p> Signup and view all the answers

What is the purpose of replacing oxygen with nitrogen inside the container?

<p>To prevent oxidation of the drug ingredients (A)</p> Signup and view all the answers

What is the purpose of adding a thickening agent in liquid preparations containing indiffusible solids?

<p>To obtain an elegant product with uniform dose (B)</p> Signup and view all the answers

Why are wetting agents used in formulations containing insoluble powders?

<p>To enhance the wetting of the powders (C)</p> Signup and view all the answers

What is the consequence of using excess surface active agents in a formulation?

<p>Claying due to deflocculation (D)</p> Signup and view all the answers

How can the insolubility of potent drugs be addressed?

<p>By converting them into salt forms (C)</p> Signup and view all the answers

What happens when a resinous tincture is added to water?

<p>The resin agglomerates forming indiffusible clots (B)</p> Signup and view all the answers

What is the purpose of using polysorbates in parenteral suspensions of corticosteroids and antibiotics?

<p>To act as a wetting agent and prevent claying (B)</p> Signup and view all the answers

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