Pharmaceutical Chemistry Quiz

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Questions and Answers

What is the route of absorption for primary amides of estrone?

  • Through the skin
  • Through injection
  • Through inhalation
  • Through the oral route (correct)

What is the chemical structure that primary amides of estrone are absorbed through?

  • R-COOH
  • R-OH
  • R-Cl
  • R-NH-C (correct)

What is the comparison being made in the text?

  • Between two types of medication
  • Between two absorption routes
  • Between two hormone structures
  • Between primary amides of estrone and carboxylic acid (correct)

What is the focus of the text?

<p>Pharmacokinetics of estrone (A)</p> Signup and view all the answers

What is the other compound being compared to primary amides of estrone?

<p>Carboxylic acid (D)</p> Signup and view all the answers

What is a characteristic of primary medications?

<p>They are broken down into smaller compounds (B)</p> Signup and view all the answers

What is the purpose of using primary medications?

<p>To enhance the absorption of poorly absorbed drugs (D)</p> Signup and view all the answers

Which of the following is an example of a primary medication?

<p>Salazin (A)</p> Signup and view all the answers

What happens to primary medications in the body?

<p>They are broken down into smaller compounds (C)</p> Signup and view all the answers

What is the result of breaking down primary medications?

<p>The formation of smaller compounds, one of which may be the active drug (D)</p> Signup and view all the answers

What is the purpose of the drug if it doesn't act locally in the gastrointestinal tract?

<p>To reach the target site through the blood circulation (D)</p> Signup and view all the answers

What is the barrier that the drug needs to pass through to reach the bloodstream?

<p>Gastrointestinal mucosal membrane (A)</p> Signup and view all the answers

What is the acid that the drug, enalapril, is converted to?

<p>Enalaprilic acid (A)</p> Signup and view all the answers

Why does the drug need to pass through the gastrointestinal mucosal membrane?

<p>To be absorbed into the bloodstream (D)</p> Signup and view all the answers

What is the chemical name of the drug?

<p>N-CH3 Enalapril (B)</p> Signup and view all the answers

What is the chemical formula for the medication chloramphenicol?

<p>C14H12Cl2N2O5 (B)</p> Signup and view all the answers

What is the name of the medication that is an example of a primary amide?

<p>Chloramphenicol (A)</p> Signup and view all the answers

What is the chemical structure of chloramphenicol?

<p>R = H, R' = CO(CH2)2OH (B)</p> Signup and view all the answers

What is the name of the medication that is a palmitate?

<p>Chloramphenicol Palmitate (C)</p> Signup and view all the answers

What is the chemical functional group found in chloramphenicol?

<p>Amide (D)</p> Signup and view all the answers

What is the status of some features?

<p>Unavailable (D)</p> Signup and view all the answers

What action is being performed?

<p>Translating a page (D)</p> Signup and view all the answers

What is the name of the translation service?

<p>Google Translate (A)</p> Signup and view all the answers

What time is mentioned in the text?

<p>8:05 (B)</p> Signup and view all the answers

What question is being asked?

<p>Is this result useful? (B)</p> Signup and view all the answers

Flashcards

Route of absorption for primary amides of estrone

Primary amides of estrone are absorbed orally.

Chemical structure for oral absorption

R-NH-C

Comparison in the text

Comparison between primary amides of estrone and carboxylic acids.

Focus of the text

Pharmacokinetics of estrone, specifically how different compounds are absorbed.

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Compound compared to primary amides

Carboxylic acid

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Characteristic of primary medications

Broken down into smaller compounds in the body.

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Purpose of primary medications

Enhance absorption of poorly absorbed drugs.

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Example of a primary medication

Salazin

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Fate of primary medications in body

Broken down into smaller compounds.

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Result of breaking down primary medications

Formation of smaller compounds, one of which may be the active drug.

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Drug purpose (non-local action)

Reach target site via blood circulation.

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Barrier for drug to bloodstream

Gastrointestinal mucosal membrane.

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Enalapril conversion acid

Enalaprilic acid

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Reason for mucosal membrane crossing

Absorption into bloodstream.

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Chemical name of enalapril

N-CH3 Enalapril

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Chloramphenicol chemical formula

C14H12Cl2N2O5

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Primary amide example

Chloramphenicol

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Chloramphenicol chemical structure

R = H, R' = CO(CH2)2OH

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Chloramphenicol palmitate

A type of chloramphenicol that is a palmitate ester.

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Chloramphenicol functional group

Amide

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Status of features

Unavailable

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Action performed

Translating a page

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Translation service name

Google Translate

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Time mentioned

8:05

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Question asked

Is this result useful?

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Study Notes

Primary Drugs

  • Primary drugs, such as prodrugs, are converted into smaller compounds, one of which is the active drug.
  • Prodrugs are used to enhance the absorption of poorly absorbed drugs from the gastrointestinal system.

Absorption of Primary Drugs

  • Primary drugs, such as esters, are absorbed orally more than carboxylic acid forms, e.g., enalapril: R = CH3, enalaprilic acid: R = H, OH.
  • Unless the purpose of the drug is to act locally in the gastrointestinal system, it must cross the gastric mucosal barrier to reach the bloodstream and then the target site.

Examples of Primary Drugs

  • Osalazine and chloramphenicol palmitate are examples of primary drugs.
  • Chloramphenicol has a molecular weight of 143.

Note

  • Some features are not available.

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