Pharmaceutical Capsules Quiz

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Questions and Answers

What is the main difference between slow-release capsules and gastro-resistant capsules?

  • Slow-release capsules are derived from type A gelatin, while gastro-resistant capsules are derived from type B gelatin.
  • Slow-release capsules release the drug slowly in the gastrointestinal tract, while gastro-resistant capsules release the drug in the intestine. (correct)
  • Slow-release capsules contain oils, while gastro-resistant capsules contain solid drugs.
  • Slow-release capsules are made of soft-shell gelatin, while gastro-resistant capsules are made of hard-shell gelatin.

What is the primary component of the capsule shell?

  • Certified dyes
  • Preservatives
  • Plasticizers
  • Gelatin blends (correct)

From which sources is gelatin derived?

  • Synthetic compounds
  • Animal bones, hide portions, and frozen pork skin (correct)
  • Mineral deposits
  • Vegetable extracts

What is the main difference between Type A and Type B gelatin?

<p>Type A is derived from acidic treated precursor with an isoelectric point at pH 9, while Type B is derived from alkali treated precursor with an isoelectric point at pH 4-7. (C)</p> Signup and view all the answers

What is the function of opaquants in the capsule shell?

<p>To make the capsule shell opaque (C)</p> Signup and view all the answers

What is the primary difference between hard-shell gelatin capsules and soft-shell gelatin capsules?

<p>Hard-shell capsules contain solid drugs, while soft-shell capsules contain oils (D)</p> Signup and view all the answers

What is the function of opaquants in the capsule shell?

<p>To prevent light from degrading the drug (D)</p> Signup and view all the answers

What is the main difference between Type A and Type B gelatin?

<p>Type A gelatin is derived from acidic treated precursor, while Type B gelatin is derived from alkali treated precursor (A)</p> Signup and view all the answers

What is the primary component of the capsule shell?

<p>Gelatin blends (C)</p> Signup and view all the answers

What is the main difference between slow-release capsules and gastro-resistant capsules?

<p>Slow-release capsules release the drug slowly in the gastrointestinal tract, while gastro-resistant capsules release the drug in the intestine (B)</p> Signup and view all the answers

Flashcards

Slow-release capsule vs Gastro-resistant capsule

Slow-release capsules release drugs slowly throughout the GI tract, while gastro-resistant capsules release drugs in the intestine.

Capsule Shell Component

Gelatin blends (often animal-derived).

Gelatin Sources

Animal bones, hides, and pork skin.

Type A vs Type B Gelatin

Type A: acidic treatment, isoelectric point pH 9; Type B: alkali treatment, pH 4-7.

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Opaquants Function

Make capsule shell opaque to prevent light degradation.

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Hard-shell vs Soft-shell Capsules

Hard-shell: solid drugs; Soft-shell: oils/liquids.

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Type A Gelatin vs Type B Gelatin

Type A is derived from acidic treated precursor, Type B is alkali treated.

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Capsule Shell primary component

Gelatin blends

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Slow release mechanism

Release drug slowly in the gastrointestinal tract

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Gastro-resistant mechanism

Release drug in the intestine

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Study Notes

Capsule Types and Components

  • Slow-release capsules and gastro-resistant capsules differ in their release mechanism: slow-release capsules release the active ingredient over an extended period, whereas gastro-resistant capsules protect the active ingredient from stomach acid and release it in the intestines.

Capsule Shell Composition

  • The primary component of the capsule shell is gelatin, derived from animal sources (bones, skin, and connective tissue) and bone-based sources (bones and bone marrow).

Gelatin Types

  • Type A gelatin is derived from acid-treated raw materials, whereas Type B gelatin is derived from alkaline-treated raw materials.

Capsule Shell Functionality

  • Opaquants are added to the capsule shell to provide opacity and prevent the entry of light, which can affect the stability of the active ingredient.

Hard-Shell vs. Soft-Shell Capsules

  • Hard-shell gelatin capsules have a rigid, two-piece shell that is filled with the active ingredient, whereas soft-shell gelatin capsules have a flexible, one-piece shell that is filled with the active ingredient.

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